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Erschienen in: Acta Diabetologica 1/2013

01.02.2013 | Original Article

Serum levels of bone resorption markers are decreased in patients with type 2 diabetes

verfasst von: Rebeca Reyes-García, Pedro Rozas-Moreno, Gema López-Gallardo, Antonia García-Martín, Mariela Varsavsky, Maria Dolores Avilés-Perez, Manuel Muñoz-Torres

Erschienen in: Acta Diabetologica | Ausgabe 1/2013

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Abstract

Previous studies of bone turnover markers in diabetes are limited, and the results are conflicting. Our aim was to evaluate differences in bone turnover markers and i-PTH between T2DM and non-diabetes subjects. Cross-sectional study including 133 subjects (78 T2DM, 55 without diabetes). BMD were measured by dual X-ray absorptiometry. Bone turnover markers were determined in serum. Serum levels of bone resorption markers (CTX and TRAP5b) were lower in T2DM compared with non-diabetes subjects. There were no differences in bone formation markers. i-PTH serum levels were lower in T2DM: 38.35 ± 18.20 pg/ml versus 50.22 ± 18.99 pg/ml, P < 0.05. TRAP5b and CTX were positively correlated with i-PTH (CTX: r = 0.443, P < 0.001; TRAP5b: r = 0.180, P = 0.047). There was an inverse relationship between TRAP5b levels and diabetes duration (r = −0.269, P = 0.021). T2DM patients have lower levels of bone resorption markers, and i-PTH compared with subjects without diabetes. Lower levels of PTH may induce a low turnover state as reflected by lower levels of bone resorption markers, and this situation may influence the higher risk of fracture of T2DM.
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Metadaten
Titel
Serum levels of bone resorption markers are decreased in patients with type 2 diabetes
verfasst von
Rebeca Reyes-García
Pedro Rozas-Moreno
Gema López-Gallardo
Antonia García-Martín
Mariela Varsavsky
Maria Dolores Avilés-Perez
Manuel Muñoz-Torres
Publikationsdatum
01.02.2013
Verlag
Springer Milan
Erschienen in
Acta Diabetologica / Ausgabe 1/2013
Print ISSN: 0940-5429
Elektronische ISSN: 1432-5233
DOI
https://doi.org/10.1007/s00592-011-0347-0

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