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04.09.2015 | Original Article

Serum metabolic profile predicts adverse central haemodynamics in patients with type 2 diabetes mellitus

verfasst von: Sonja B. Nikolic, Lindsay M. Edwards, Yuliya V. Karpievitch, Richard Wilson, James Horne, Murray J. Adams, James E. Sharman

Erschienen in: Acta Diabetologica | Ausgabe 3/2016

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Abstract

Aims

People with type 2 diabetes mellitus (T2DM) have abnormal peripheral and central haemodynamics at rest and during exercise, probably due to metabolic perturbations, but mechanisms are unknown. We used untargeted metabolomics to determine the relationships between metabolic perturbations and haemodynamics (peripheral and central) measured at rest and during exercise.

Methods

Serum samples from 39 participants with T2DM (62 ± 9 years; 46 % male) and 39 controls (52 ± 10 years; 51 % male) were analysed by liquid chromatography–mass spectrometry, nuclear magnetic resonance spectroscopy and principal component analysis. Scores on principal components (PC) were used to assess relationships with haemodynamics including peripheral and central BP, central augmentation index (AIx) and central augmentation pressure (AP).

Results

Participants with T2DM had higher resting and exercise haemodynamics (peripheral and central BP, central AIx and central AP) compared to controls (p < 0.05). PC that comprised of a signature metabolic pattern of T2DM was independently associated with resting and exercise central AIx and central AP (p < 0.05).

Conclusions

Serum metabolic profile was associated with central, but not peripheral, haemodynamics in T2DM participants, suggesting that metabolic irregularities may explain abnormal central haemodynamics in T2DM patients.

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Titel: Serum metabolic profile predicts adverse central haemodynamics in patients with type 2 diabetes mellitus
verfasst von: Sonja B. Nikolic
Lindsay M. Edwards
Yuliya V. Karpievitch
Richard Wilson
James Horne
Murray J. Adams
James E. Sharman
Publikationsdatum: 04.09.2015
Verlag: Springer Milan
Erschienen in: Acta Diabetologica / Ausgabe 3/2016
Print ISSN: 0940-5429
Elektronische ISSN: 1432-5233
DOI: https://doi.org/10.1007/s00592-015-0802-4

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Serum metabolic profile predicts adverse central haemodynamics in patients with type 2 diabetes mellitus

Abstract

Aims

Methods

Results

Conclusions

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Parodontalbehandlung verbessert Prognose bei Katheterablation

Antihypertensiva schützen auch alte Menschen noch vor Demenz

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Denken Sie bei starker Blutung auch an die Hemmkörper-Hämophilie

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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Abstract

Aims

Methods

Results

Conclusions

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