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Surgery Today
Erschienen in: Surgery Today 10/2016

16.12.2015 | Review Article

Hereditary gastrointestinal cancer

verfasst von: Keisuke Hata, Yoko Yamamoto, Tomomichi Kiyomatsu, Toshiaki Tanaka, Shinsuke Kazama, Hiroaki Nozawa, Kazushige Kawai, Junichiro Tanaka, Takeshi Nishikawa, Kensuke Otani, Koji Yasuda, Junko Kishikawa, Yuzo Nagai, Hiroyuki Anzai, Takahide Shinagawa, Keiichi Arakawa, Hironori Yamaguchi, Soichiro Ishihara, Eiji Sunami, Joji Kitayama, Toshiaki Watanabe

Erschienen in: Surgery Today | Ausgabe 10/2016

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Abstract

Gastrointestinal (GI) cancer, including gastric and colorectal cancer, is a major cause of death worldwide. A substantial proportion of patients with GI cancer have a familial history, and several causative genes have been identified. Gene carriers with these hereditary GI syndromes often harbor several kinds of cancer at an early age, and genetic testing and specific surveillance may save their lives through early detection. Gastroenterologists and GI surgeons should be familiar with these syndromes, even though they are not always associated with a high penetrance of GI cancer. In this review, we provide an overview and discuss the diagnosis, genetic testing, and management of four major hereditary GI cancers: familial adenomatous polyposis, Lynch syndrome, hereditary diffuse gastric cancer, and Li–Fraumeni syndrome.
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Metadaten
Titel
Hereditary gastrointestinal cancer
verfasst von
Keisuke Hata
Yoko Yamamoto
Tomomichi Kiyomatsu
Toshiaki Tanaka
Shinsuke Kazama
Hiroaki Nozawa
Kazushige Kawai
Junichiro Tanaka
Takeshi Nishikawa
Kensuke Otani
Koji Yasuda
Junko Kishikawa
Yuzo Nagai
Hiroyuki Anzai
Takahide Shinagawa
Keiichi Arakawa
Hironori Yamaguchi
Soichiro Ishihara
Eiji Sunami
Joji Kitayama
Toshiaki Watanabe
Publikationsdatum
16.12.2015
Verlag
Springer Japan
Erschienen in
Surgery Today / Ausgabe 10/2016
Print ISSN: 0941-1291
Elektronische ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-015-1283-3

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