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01.01.2012 | Clinical Article

Chemokines as markers of local inflammation and angiogenesis in patients with chronic subdural hematoma: a prospective study

verfasst von: Milo Stanisic, Staale Petter Lyngstadaas, Are Hugo Pripp, Ansgar Oddne Aasen, Karl-Fredrik Lindegaard, Jugoslav Ivanovic, Eivind Ilstad, Ane Konglund, Tiril Sandell, Omar Ellingsen, Terje Sæhle

Erschienen in: Acta Neurochirurgica | Ausgabe 1/2012

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Abstract

Objective

The goal of this study was to investigate the chemokines CCL2, CXCL8, CXCL9 and CXCL10 as markers of the inflammatory responses in chronic subdural hematoma (CSDH).

Methods

Samples of peripheral venous blood and CSDH fluid (obtained during surgery) in 76 adult patients were prospectively analyzed. Chemokine values were assessed by a Multiplex antibody bead kit.

Results

We found significantly higher levels of chemokines CCL2, CXCL8, CXCL9 and CXCL10 in hematoma fluid compared with serum.

Conclusions

Chemokines are elevated in the hematoma cavity of patients with CSDH. It is likely that these signaling modulators play an important role in promoting local inflammation. Furthermore, biological activity of CCL2 and CXCL8 may promote neovascularization within the outer CSDH membrane, and a compensatory angiostatic activity of CXCL9 and CXCL10 may contribute to repairing this disorder. This phenomenon was restricted to the hematoma site, and the systemic chemokine levels might not reflect local immune responses.

Angiolillo AL, Sgadari C, Taub DD, Liao F, Farber JM, Maheshwari S, Kleinman HK, Reaman GH, Tosato G (1995) Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo. J Exp Med 182:155–162PubMedCrossRef

Bacon K, Baggiolini M, Broxmeyer H, Horuk R, Lindley I, Mantovani A, Maysushima K, Murphy P, Nomiyama H, Oppenheim J, Rot A, Schall T, Tsang M, Thorpe R, Van Damme J, Wadhwa M, Yoshie O, Zlotnik A, Zoon K (2002) Chemokine/chemokine receptor nomenclature. J Interferon Cytokine Res 22:1067–1068PubMedCrossRef

Baggiolini M, Dewald B, Moser B (1994) Interleukin-8 and related chemotactic cytokines-CXC and CC chemokines. Adv Immunol 55:97–179PubMedCrossRef

Bagglioni M (1998) Chemokines and leukocyte traffic. Nature 392:565–568CrossRef

Belperio JA, Keane MP, Arenberg DA, Addison CL, Ehlert JE, Burdick MD, Strieter RM (2000) CXC chemokines in angiogenesis. J Leukoc Biol 68:1–8PubMed

Carr MW, Roth SJ, Luther E, Rose SS, Springer TA (1994) Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant. Proc Natl Acad Sci USA 91:3652–3656PubMedCrossRef

Charo IF, Ransohoff RM (2006) The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med 354:610–621PubMedCrossRef

Chen JC, Levi ML (2000) Causes, epidemiology, and risk factors of chronic subdural hematoma. Neurosurg Clin N Am 11:399–406PubMed

Craig MJ, Loberg RD (2006) CCL2 (Monocyte chemoattractant protein-1) in cancer bone metastases. Cancer Metastasis Rev 25:611–619PubMedCrossRef

10.

Daly C, Rollins BJ (2003) Monocyte chemoattractant protein-1 (CCL2) in inflammatory disease and adaptive immunity: therapeutic opportunities and controversies. Microcirculation 10:247–257PubMed

11.

Dewald O, Zymek P, Winkelmann K, Koerting A, Ren G, Abou-Khamis T, Loyd HM, Rollins BJ, Entman ML, Frangogiannis NG (2005) CCL2/monocyte chemoattractant protein-1 regulates inflammatory responses critical to healing myocardial infarcts. Circ Res 96:881–889PubMedCrossRef

12.

Dufour JH, Dziejman M, Liu MT, Leung JH, Lane TE, Luster AD (2002) IFN-γ-inducible protein 10 (IP-10;CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking. J Immunol 168:3195–3204PubMed

13.

Frati A, Salvati M, Mainiero F, Ippoliti F, Rocchi G, Raco A, Caroli E, Cantore G, Delfini R (2004) Inflammation markers and risk factors for recurrence in 35 patients with a posttraumatic chronic subdural hematoma: a prospective study. J Neurosurg 100:24–32PubMed

14.

Friede RL, Schachenmayer W (1978) The origin of subdural neomembranes. II. Fine structure of neomembranes. Amer J Pathol 92:69–84

15.

Gasperini S, Marchi M, Calzetti F, Laudanna C, Vicentini L, Olsen H, Murphy M, Liao F, Farber J, Cassatella MA (1999) Gene expression and production of the monokine induced by IFN-gamma (MIG), INF-alpha inducible T cell chemoattractant (I-TAC), and IFN-gamma-inducible protein-10 (IP-10) chemokines by human neutrophils. J Immunol 162:4928–4937PubMed

16.

Golden J, Frim DM, Chapman PH, Vonsattel JP (1994) Marked tissue eosinophilia within organizing chronic subdural haematoma membranes. Clin Neuropathol 13:12–16PubMed

17.

Haines DE, Harkey HL, al-Mefty O (1993) The “subdural” space: a new look at an outdated concept. Neurosurgery 32:111–120PubMedCrossRef

18.

Hirashima Y, Endo S, Kato R, Ohmori T, Nagahori T, Nishijima M, Karasawa K, Nojima S, Takaku A (1994) Platelet-activating factor (PAF) and the development of chronic subdural haematoma. Acta Neurochir (Wien) 129:20–25CrossRef

19.

Hohenstein A, Erber R, Schilling L, Weigel R (2005) Increased mRNA expression of VEGF within the hematoma and imbalance of angiopoietin-1 and −2 mRNA within the neomembranes of chronic subdural hematoma. J Neurotraum 22:518–528CrossRef

20.

Hong HJ, Kim YJ, Yi HJ, Ko Y, Oh SJ, Kim JM (2009) Role of angiogenic growth factors and Inflammatory cytokine on recurrence of chronic subdural hematoma. Surg Neurol 71:161–166PubMedCrossRef

21.

Hristov M, Zernecke A, Bidzhekov K, Liehn EA, Shagdarsuren E, Ludwig A, Weber C (2007) Importance of CXC chemokine receptor 2 in the homing of human peripheral blood endothelial progenitor cells to sites of arterial injury. Circ Res 100:590–597PubMedCrossRef

22.

Janatpour MJ, Hudak S, Sathe M, Sedgwick JD, McEvoy LM (2001) Tumor necrosis factor-dependent segmental control of MIG expression by high endothelial venules in inflamed lymph nodes regulates monocyte recruitment. J Exp Med 194:1375–1384PubMedCrossRef

23.

Jones ML, Warren JS (1992) Monocyte chemoattractant protein 1 in rat model of pulmonary granulomatosis. Lab Invest 66:498–503PubMed

24.

Katano H, Kamiya K, Mase M, Tanikawa M, Yamada K (2006) Tissue plasminogen activator in chronic subdural hematomas as a predictor of recurrence. J Neurosurg 104:79–84PubMedCrossRef

25.

Kawano N, Suzuki K (1981) Presence of smooth-muscle cells in the subdural neomembrane. J Neurosurg 54:646–651PubMedCrossRef

26.

Keeley EC, Mehrad B, Strieter RM (2008) Chemokines as mediators of neovascularization. Arterioscl Thromb Vasc Biol 28:1928–1936PubMedCrossRef

27.

Koch AE, Volin MV, Woods JM, Kunkel SL, Connors MA, Harlow LA, Woodruff DC, Burdick MD, Strieter RM (2001) Regulation of angiogenesis by the C-X-C chemokines IL-8 and epithelial neutrophil activating peptide 78 in the rheumatoid joint. Arthritis Rheum 44:31–40PubMedCrossRef

28.

Kuan WP, Tam LS, Wong CK, Ko FWS, Li T, Zhu T, Li EK (2010) CXCL9 and CXCL10 as sensitive markers of disease activity in patients with rheumatoid arthritis. J Rheumatol 37:257–264PubMedCrossRef

29.

Lasagni L, Francalanci M, Annunziato F, Lazzeri E, Giannini S, Cosmi L, Sagrinati C, Mazzinghi B, Orlando C, Maggi E, Marra F, Romagnani S, Serio M, Romagnani P (2003) An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and 1-TAC, and acts as functional receptor for platelet factor 4. J Exp Med 197:1537–1549PubMedCrossRef

30.

Li A, Varney ML, Valasek J, Godfrey M, Dave BJ, Singh RK (2005) Autocrine role of interleukin-8 in induction of endothelial cell proliferation, survival, migration and MMP2 production and angiogenesis. Angiogenesis 8:63–71PubMedCrossRef

31.

Liao F, Rabin RL, Yannelli JR, Koniaris LG, Vanguri P, Farber JM (1995) Human Mig chemokine: biochemical and functional characterization. J Exp Med 182:1301–1314PubMedCrossRef

32.

Luster AD (1998) Chemokines—chemotactic cytokines that mediated inflammation. NEJM 338:436–445PubMedCrossRef

33.

Mahad DJ, Ransohoff RM (2003) The role of MCP-1 (CCL2) and CCR2 in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). Semin Immunol 15:23–32PubMedCrossRef

34.

Matsushima K, Oppenheim JJ (1998) Interleukin 8 and MCAF: novel inflammatory cytokines inducible by IL1 and TNF. Cytokine 1:2–13CrossRef

35.

Mehrad B, Keane MP, Strieter RM (2007) Chemokines as mediators of angiogenesis. Thromb Haemost 97:755–762PubMed

36.

Moskala M, Gościński I, Kałuża J, Polak J, Krupa M, Adamek D, Pityński K, Miodoński AJ (2007) Morphological aspects of the traumatic chronic subdural hematoma capsule: SEM studies. Microsc Microanal 13:211–219PubMedCrossRef

37.

Müller W, Firsching R (1990) Significance of eosinophilic granulocytes in chronic subdural haematomas. Neurosurg Rev 13:305–308PubMedCrossRef

38.

Murdoch C, Monk PN, Finn A (1999) Cxc chemokine receptor expression on human endothelial cells. Cytokine 11:704–712PubMedCrossRef

39.

Nanko N, Tanikawa M, Mase M, Fujita M, Tateyama H, Miyati T, Yamada K (2009) Involvement of hypoxia-inducible factor-1α and vascular endothelial growth factor in the mechanism of development of chronic subdural hematoma. Neurol Med Chir (Tokyo) 49:379–385CrossRef

40.

Pawelec G (2006) Immunity and aging in man. Exp Gerontol 41:1239–1242PubMedCrossRef

41.

Premack BA, Schall TJ (1996) Chemokine receptors: gateways to inflammation and infection. Nat Med 2:1174–1178PubMedCrossRef

42.

Rot A, von Adrian UH (2004) Chemokines in innate and adoptive host defense: basic chemokinese grammar for immune cells. Annu Rev Immunol 22:891–928PubMedCrossRef

43.

Salcedo R, Ponce ML, Young HA, Wasserman K, Ward JM, Kleinman HK, Oppenheim JJ, Murphy WJ (2000) Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression. Blood 96:34–40PubMed

44.

Sarkar C, Lakhtakia R, Gill SS, Sharma MC, Mahapatra AK, Mehta VS (2002) Chronic subdural haematoma and the enigmatic eosinophil. Acta Neurochir (Wien) 144:983–988CrossRef

45.

Schachenmayer W, Friede RL (1978) The origin of subdural neomembranes. I. Fine structure of the dura-arachnoid interface in man. Amer J Pathol 92:53–68

46.

Schröder JM, Christophers E (1992) The biology of NAP-1/IL-8, a neutrophil-activating cytokine. Immunol Ser 57:387–416PubMed

47.

Shono T, Inamura T, Morioka T, Matsumoto K, Suzuki SO, Ikezaki K, Iwaki T, Fukui M (2001) Vascular endothelial growth factor in chronic subdural haematomas. J Clin Neurosci 8:411–415PubMedCrossRef

48.

Smith RM (2007) Immunity, trauma and the eldery. Injury 38:1401–1404PubMedCrossRef

49.

Stamatovic SM, Keep RF, Mostarica-Stojkovic M, Andjelkovic AV (2006) CCL2 regulates angiogenesis via activation of Ets-1 transcription factor. J Immunol 177:2651–2661PubMed

50.

Stoodley M, Weir B (2000) Contents of chronic subdural hematoma. Neurosurg Clin N Am 11:425–434PubMed

51.

Strieter RM, Polverini PJ, Kunkel SL, Arenberg DA, Burdick MD, Kasper J, Dzuiba J, Van Damme J, Walz A, Marriott D, Chan S, Roczniak S, Shanafelt AB (1995) The functional role of the ELR motif in CXC chemokine-mediated angiogenesis. J Biol Chem 270:27348–27357PubMedCrossRef

52.

Suzuki K, Takano S, Nose T, Doi M, Ohasi N (1999) Increased concentration of vascular endothelial growth factor (VEGF) in chronic subdural hematoma. J Traum 46:532–533, LetterCrossRef

53.

Suzuki M, Endo S, Inada K, Kudo A, Kitakami A, Kuroda K, Ogawa A (1998) Inflammatory cytokines locally elevated in chronic subdural haematoma. Acta Neurochir (Wien) 140:51–55CrossRef

54.

Tensen CP, Flier J, Van Der Raaij-Helmer EM, Sampat-Sardjoepersad S, Van Der Schors RC, Leurs R, Scheper RJ, Boorsma DM, Willemze R (1999) Human IP-9: a keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/MIG receptor (CXCR3). J Invest Dermatol 112:716–722PubMedCrossRef

55.

Vaquero J, Zurita M, Cincu R (2002) Vascular endothelial growth-permeability factor in granulation tissue of chronic subdural haematomas. Acta Neurochir (Wien) 144:343–347CrossRef

56.

Vlahopoulos S, Boldogh I, Casola A, Brasier AR (1999) Nuclear factor-kappaB-dependent induction of interleukin-8 gene expression by tumor necrosis factor alpha: evidence for an antioxidant sensitive activating pathway distinct from nuclear translocation. Blood 94:1878–1889PubMed

57.

Wada T, Kuroda K, Yoshida Y (2006) Local elevation of the anti-inflammatory interleukin-10 in the pathogenesis of chronic subdural hematoma. Neurosurg Rev 29:242–245PubMedCrossRef

58.

Weber KS, Nelson PJ, Grone HJ, Weber C (1999) Expression of CCR2 by endothelial cells: implications for MCP-1 mediated wound injury repair and in vivo inflammatory activation of endothelium. Arterioscler Thromb Vasc Biol 19:2085–2093PubMedCrossRef

59.

Weigel R, Schilling L, Schmiedek P (2001) Specific pattern of growth factor distribution in chronic subdural hematoma (CSH): evidence for an angiogenic disease. Acta Neurochir (Wien) 143:811–819CrossRef

60.

Weigel R, Schmiedek P, Krauss JK (2003) Outcome of contemporary surgery for chronic subdural haematoma: evidence based review. J Neurol Neurosurg Psychiatry 74:937–943PubMedCrossRef

61.

Wolff B, Burns AR, Middleton J, Rot A (1998) Endothelial cell “memory” of inflammatory stimulation: human venular endothelial cells store interleukin 8 in Weibel-Palade bodies. J Exp Med 188:1757–1762PubMedCrossRef

62.

Xu LL, Warren MK, Rose WL, Gong W, Wang JM (1996) Human recombinant monocyte chemotactic protein and other C-C chemokines bind and induce directional migration of dendritic cells in vitro. J Leukoc Biol 60:365–371PubMed

63.

Yamashima T, Yamamoto S (1985) The origin of inner membranes in chronic subdural hematomas. Acta Neuropathol 67:219–225PubMedCrossRef

64.

Yang J, Richmond A (2004) The angiostatic activity of INF-inducible protein-10/CXCL10 in human melanoma depends on binding to CXCR3 but not to glycosaminoglycan. Mol Ther 9:846–855PubMedCrossRef

65.

Zwahlen R, Walz A, Rot A (1993) In vitro an in vivo activity and pathophysiology of human interleukin-8 and related peptides. Int Rev Exp Pathol 34:27–42PubMed

Titel: Chemokines as markers of local inflammation and angiogenesis in patients with chronic subdural hematoma: a prospective study
verfasst von: Milo Stanisic
Staale Petter Lyngstadaas
Are Hugo Pripp
Ansgar Oddne Aasen
Karl-Fredrik Lindegaard
Jugoslav Ivanovic
Eivind Ilstad
Ane Konglund
Tiril Sandell
Omar Ellingsen
Terje Sæhle
Publikationsdatum: 01.01.2012
Verlag: Springer Vienna
Erschienen in: Acta Neurochirurgica / Ausgabe 1/2012
Print ISSN: 0001-6268
Elektronische ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-011-1203-2

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Chemokines as markers of local inflammation and angiogenesis in patients with chronic subdural hematoma: a prospective study

Abstract

Objective

Methods

Results

Conclusions

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Abstract

Objective

Methods

Results

Conclusions

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