Skip to main content
Erschienen in: Acta Neurochirurgica 11/2018

20.09.2018 | Original Article - Neurosurgery general

Survey of the management of perioperative bridging of anticoagulation and antiplatelet therapy in neurosurgery

verfasst von: Marco Skardelly, Lisa Mönch, Constantin Roder, Konstantin Hockel, Marcos Soares Tatagiba, Florian H. Ebner

Erschienen in: Acta Neurochirurgica | Ausgabe 11/2018

Einloggen, um Zugang zu erhalten

Abstract

Background

A growing number of patients on anticoagulation or antiplatelet therapy (APT) are planned for elective surgery. The management of perioperative anticoagulation and APT is challenging because it must balance the risk of thromboembolism and bleeding, and specific recommendations for the management of bridging in neurosurgical patients are lacking. We surveyed German neurosurgical centers about their management of perioperative bridging of anticoagulation and APT to provide an overview of the current bridging policy.

Method

From April to August 2016, all German neurosurgical departments were invited to participate in the survey. We used SurveyMonkey to compose ten questions and to conduct the survey, and we defined three different approaches for the perioperative management of patients on a preexisting medication: medication will be discontinued (A) with perioperative “bridging” and (B) without perioperative bridging, or (C) medication will be continued perioperatively.

Results

Out of 141 respondents, 84 (60%) partially and 77 (55%) fully completed the questionnaire. No defined policy for the perioperative management of anticoagulation and APT was established in 60.7% (51/84) of participating centers. The perioperative management of anticoagulation and APT varied widely among different centers in all items of the questionnaire; for example, in the group of patients at high risk for thromboembolism, acetylsalicylic acid was discontinued in 22%, bridged in 35%, and continued in 35% of centers.

Conclusions

There is significant uncertainty regarding the management of perioperative bridging of anticoagulation and APT in neurosurgery because of a lack of prospective and limited retrospective data.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Baron TH, Kamath PS, McBane RD (2013) Management of antithrombotic therapy in patients undergoing invasive procedures. N Engl J Med 368(22):2113–2124CrossRef Baron TH, Kamath PS, McBane RD (2013) Management of antithrombotic therapy in patients undergoing invasive procedures. N Engl J Med 368(22):2113–2124CrossRef
2.
Zurück zum Zitat Cannegieter SC, Rosendaal FR, Briët E (1994) Thromboembolic and bleeding complications in patients with mechanical heart valve prostheses. Circulation 89(2):635–641CrossRef Cannegieter SC, Rosendaal FR, Briët E (1994) Thromboembolic and bleeding complications in patients with mechanical heart valve prostheses. Circulation 89(2):635–641CrossRef
3.
Zurück zum Zitat Capodanno D, Musumeci G, Lettieri C, Limbruno U, Senni M, Guagliumi G, Valsecchi O, Angiolillo DJ, Rossini R (2015) Impact of bridging with perioperative low-molecular-weight heparin on cardiac and bleeding outcomes of stented patients undergoing non-cardiac surgery. Thromb Haemost 114(2):423–431PubMed Capodanno D, Musumeci G, Lettieri C, Limbruno U, Senni M, Guagliumi G, Valsecchi O, Angiolillo DJ, Rossini R (2015) Impact of bridging with perioperative low-molecular-weight heparin on cardiac and bleeding outcomes of stented patients undergoing non-cardiac surgery. Thromb Haemost 114(2):423–431PubMed
4.
Zurück zum Zitat Chugh SS, Havmoeller R, Narayanan K, Singh D, Rienstra M, Benjamin EJ, Gillum RF, Kim YH, McAnulty JH, Zheng ZJ, Forouzanfar MH, Naghavi M, Mensah GA, Ezzati M, Murray CJL (2014) Worldwide epidemiology of atrial fibrillation: a Global Burden of Disease 2010 Study. Circulation 129(8):837–847CrossRef Chugh SS, Havmoeller R, Narayanan K, Singh D, Rienstra M, Benjamin EJ, Gillum RF, Kim YH, McAnulty JH, Zheng ZJ, Forouzanfar MH, Naghavi M, Mensah GA, Ezzati M, Murray CJL (2014) Worldwide epidemiology of atrial fibrillation: a Global Burden of Disease 2010 Study. Circulation 129(8):837–847CrossRef
5.
Zurück zum Zitat Devereaux PJ, Mrkobrada M, Sessler DI, Leslie K, Alonso-Coello P, Kurz A, Villar JC, Sigamani A, Biccard BM, Meyhoff CS, Parlow JL, Guyatt G, Robinson A, Garg AX, Rodseth RN, Botto F, Lurati Buse G, Xavier D, Chan MTV, Tiboni M, Cook D, Kumar PA, Forget P, Malaga G, Fleischmann E, Amir M, Eikelboom J, Mizera R, Torres D, Wang CY, VanHelder T, Paniagua P, Berwanger O, Srinathan S, Graham M, Pasin L, Le Manach Y, Gao P, Pogue J, Whitlock R, Lamy A, Kearon C, Baigent C, Chow C, Pettit S, Chrolavicius S, Yusuf S (2014) Aspirin in patients undergoing noncardiac surgery. N Engl J Med 370(16):1494–1503CrossRef Devereaux PJ, Mrkobrada M, Sessler DI, Leslie K, Alonso-Coello P, Kurz A, Villar JC, Sigamani A, Biccard BM, Meyhoff CS, Parlow JL, Guyatt G, Robinson A, Garg AX, Rodseth RN, Botto F, Lurati Buse G, Xavier D, Chan MTV, Tiboni M, Cook D, Kumar PA, Forget P, Malaga G, Fleischmann E, Amir M, Eikelboom J, Mizera R, Torres D, Wang CY, VanHelder T, Paniagua P, Berwanger O, Srinathan S, Graham M, Pasin L, Le Manach Y, Gao P, Pogue J, Whitlock R, Lamy A, Kearon C, Baigent C, Chow C, Pettit S, Chrolavicius S, Yusuf S (2014) Aspirin in patients undergoing noncardiac surgery. N Engl J Med 370(16):1494–1503CrossRef
6.
Zurück zum Zitat Douketis JD, Healey JS, Brueckmann M, Eikelboom JW, Ezekowitz MD, Fraessdorf M, Noack H, Oldgren J, Reilly P, Spyropoulos AC, Wallentin L, Connolly SJ (2015) Perioperative bridging anticoagulation during dabigatran or warfarin interruption among patients who had an elective surgery or procedure. Substudy of the RE-LY trial. Thromb Haemost 113(3):625–632CrossRef Douketis JD, Healey JS, Brueckmann M, Eikelboom JW, Ezekowitz MD, Fraessdorf M, Noack H, Oldgren J, Reilly P, Spyropoulos AC, Wallentin L, Connolly SJ (2015) Perioperative bridging anticoagulation during dabigatran or warfarin interruption among patients who had an elective surgery or procedure. Substudy of the RE-LY trial. Thromb Haemost 113(3):625–632CrossRef
7.
Zurück zum Zitat Douketis JD, Spyropoulos AC, Kaatz S, Becker RC, Caprini JC, Dunn AS, Garcia DA, Jacobson A, Jaffer AK, Kong DF, Schulman S, Turpie AGG, Hasselblad V, Ortel TL (2015) Perioperative bridging anticoagulation in patients with atrial fibrillation. N Engl J Med 373(9):823–833CrossRef Douketis JD, Spyropoulos AC, Kaatz S, Becker RC, Caprini JC, Dunn AS, Garcia DA, Jacobson A, Jaffer AK, Kong DF, Schulman S, Turpie AGG, Hasselblad V, Ortel TL (2015) Perioperative bridging anticoagulation in patients with atrial fibrillation. N Engl J Med 373(9):823–833CrossRef
8.
Zurück zum Zitat Douketis JD, Spyropoulos AC, Spencer FA, Mayr M, Jaffer AK, Eckman MH, Dunn AS, Kunz R (2012) Perioperative management of antithrombotic therapy. Chest 141((2):e326S–e350SCrossRef Douketis JD, Spyropoulos AC, Spencer FA, Mayr M, Jaffer AK, Eckman MH, Dunn AS, Kunz R (2012) Perioperative management of antithrombotic therapy. Chest 141((2):e326S–e350SCrossRef
9.
Zurück zum Zitat Dunn AS, Spyropoulos AC, Turpie AGG (2007) Bridging therapy in patients on long-term oral anticoagulants who require surgery: the Prospective Peri-operative Enoxaparin Cohort Trial (PROSPECT). J Thromb Haemost 5(11):2211–2218CrossRef Dunn AS, Spyropoulos AC, Turpie AGG (2007) Bridging therapy in patients on long-term oral anticoagulants who require surgery: the Prospective Peri-operative Enoxaparin Cohort Trial (PROSPECT). J Thromb Haemost 5(11):2211–2218CrossRef
10.
Zurück zum Zitat Gage BF, Waterman AD, Shannon W, Boechler M, Rich MW, Radford MJ (2001) Validation of clinical classification schemes for predicting stroke: results from the National Registry of Atrial Fibrillation. JAMA 285(22):2864–2870CrossRef Gage BF, Waterman AD, Shannon W, Boechler M, Rich MW, Radford MJ (2001) Validation of clinical classification schemes for predicting stroke: results from the National Registry of Atrial Fibrillation. JAMA 285(22):2864–2870CrossRef
11.
Zurück zum Zitat Garcia D, Alexander JH, Wallentin L, Wojdyla DM, Thomas L, Hanna M, Al-Khatib SM, Dorian P, Ansell J, Commerford P, Flaker G, Lanas F, Vinereanu D, Xavier D, Hylek EM, Held C, Verheugt FWA, Granger CB, Lopes RD (2014) Management and clinical outcomes in patients treated with apixaban vs warfarin undergoing procedures. Blood 124(25):3692–3698CrossRef Garcia D, Alexander JH, Wallentin L, Wojdyla DM, Thomas L, Hanna M, Al-Khatib SM, Dorian P, Ansell J, Commerford P, Flaker G, Lanas F, Vinereanu D, Xavier D, Hylek EM, Held C, Verheugt FWA, Granger CB, Lopes RD (2014) Management and clinical outcomes in patients treated with apixaban vs warfarin undergoing procedures. Blood 124(25):3692–3698CrossRef
12.
Zurück zum Zitat Hamilton MG, Yee WH, Hull RD, Ghali WA (2011) Venous thromboembolism prophylaxis in patients undergoing cranial neurosurgery: a systematic review and meta-analysis. Neurosurgery 68(3):571–581CrossRef Hamilton MG, Yee WH, Hull RD, Ghali WA (2011) Venous thromboembolism prophylaxis in patients undergoing cranial neurosurgery: a systematic review and meta-analysis. Neurosurgery 68(3):571–581CrossRef
13.
Zurück zum Zitat Iorio A, Agnelli G (2000) Low-molecular-weight and unfractionated heparin for prevention of venous thromboembolism in neurosurgery: a meta-analysis. Arch Intern Med 160(15):2327–2332CrossRef Iorio A, Agnelli G (2000) Low-molecular-weight and unfractionated heparin for prevention of venous thromboembolism in neurosurgery: a meta-analysis. Arch Intern Med 160(15):2327–2332CrossRef
14.
Zurück zum Zitat Kearon C, Akl EA, Comerota AJ, Prandoni P, Bounameaux H, Goldhaber SZ, Nelson ME, Wells PS, Gould MK, Dentali F, Crowther M, Kahn SR (2012) Antithrombotic therapy for VTE disease: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 141(2 Suppl):e419S–e496SCrossRef Kearon C, Akl EA, Comerota AJ, Prandoni P, Bounameaux H, Goldhaber SZ, Nelson ME, Wells PS, Gould MK, Dentali F, Crowther M, Kahn SR (2012) Antithrombotic therapy for VTE disease: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 141(2 Suppl):e419S–e496SCrossRef
15.
Zurück zum Zitat Lazio BE, Simard JM (1999) Anticoagulation in neurosurgical patients. Neurosurgery 45(4):838–47– discussion 847–8CrossRef Lazio BE, Simard JM (1999) Anticoagulation in neurosurgical patients. Neurosurgery 45(4):838–47– discussion 847–8CrossRef
16.
Zurück zum Zitat Mittal R, Huggins NJ, Varma MK (2012) A59 A U.K. survey of neurosurgical practice for the pre-operative discontinuation of aspirin/clopidogrel. Eur J Anaesthesiol 29:S18CrossRef Mittal R, Huggins NJ, Varma MK (2012) A59 A U.K. survey of neurosurgical practice for the pre-operative discontinuation of aspirin/clopidogrel. Eur J Anaesthesiol 29:S18CrossRef
17.
Zurück zum Zitat Palmer JD, Sparrow OC, Iannotti F (1994) Postoperative hematoma: a 5-year survey and identification of avoidable risk factors. Neurosurgery 35(6):1061–4– discussion 1064–5CrossRef Palmer JD, Sparrow OC, Iannotti F (1994) Postoperative hematoma: a 5-year survey and identification of avoidable risk factors. Neurosurgery 35(6):1061–4– discussion 1064–5CrossRef
18.
Zurück zum Zitat Rachinger JC, Koman G, Scheller C, Prell J, Rampp S, Strauss C (2011) Practice in the perioperative prevention of deep vein thrombosis in German neurosurgical departments—is there a trend towards homogenization? Cen Eur Neurosurg 72(03):115–119CrossRef Rachinger JC, Koman G, Scheller C, Prell J, Rampp S, Strauss C (2011) Practice in the perioperative prevention of deep vein thrombosis in German neurosurgical departments—is there a trend towards homogenization? Cen Eur Neurosurg 72(03):115–119CrossRef
19.
Zurück zum Zitat Rahman M, Donnangelo LL, Neal D, Mogali K, Decker M, Ahmed MM (2015) Effects of perioperative acetyl salicylic acid on clinical outcomes in patients undergoing craniotomy for brain tumor. World Neurosurgery 84(1):41–47CrossRef Rahman M, Donnangelo LL, Neal D, Mogali K, Decker M, Ahmed MM (2015) Effects of perioperative acetyl salicylic acid on clinical outcomes in patients undergoing craniotomy for brain tumor. World Neurosurgery 84(1):41–47CrossRef
20.
Zurück zum Zitat Sherwood MW, Douketis JD, Patel MR, Piccini JP, Hellkamp AS, Lokhnygina Y, Spyropoulos AC, Hankey GJ, Singer DE, Nessel CC, Mahaffey KW, Fox KAA, Califf RM, Becker RC (2014) Outcomes of temporary interruption of rivaroxaban compared with warfarin in patients with nonvalvular atrial fibrillation: results from the rivaroxaban once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation (ROCKET AF). Circulation 129(18):1850–1859CrossRef Sherwood MW, Douketis JD, Patel MR, Piccini JP, Hellkamp AS, Lokhnygina Y, Spyropoulos AC, Hankey GJ, Singer DE, Nessel CC, Mahaffey KW, Fox KAA, Califf RM, Becker RC (2014) Outcomes of temporary interruption of rivaroxaban compared with warfarin in patients with nonvalvular atrial fibrillation: results from the rivaroxaban once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation (ROCKET AF). Circulation 129(18):1850–1859CrossRef
21.
Zurück zum Zitat Siegal D, Yudin J, Kaatz S, Douketis JD, Lim W, Spyropoulos AC (2012) Periprocedural heparin bridging in patients receiving vitamin K antagonists: systematic review and meta-analysis of bleeding and thromboembolic rates. Circulation 126(13):1630–1639CrossRef Siegal D, Yudin J, Kaatz S, Douketis JD, Lim W, Spyropoulos AC (2012) Periprocedural heparin bridging in patients receiving vitamin K antagonists: systematic review and meta-analysis of bleeding and thromboembolic rates. Circulation 126(13):1630–1639CrossRef
22.
Zurück zum Zitat Skeith L, Lazo-Langner A, Kovacs MJ (2013) The equipoise of perioperative anticoagulation management: a Canadian cross-sectional survey. J Thromb Thrombolysis 37(4):411–413CrossRef Skeith L, Lazo-Langner A, Kovacs MJ (2013) The equipoise of perioperative anticoagulation management: a Canadian cross-sectional survey. J Thromb Thrombolysis 37(4):411–413CrossRef
23.
Zurück zum Zitat Spyropoulos AC, Douketis JD (2012) How I treat anticoagulated patients undergoing an elective procedure or surgery. Blood 120(15):2954–2962CrossRef Spyropoulos AC, Douketis JD (2012) How I treat anticoagulated patients undergoing an elective procedure or surgery. Blood 120(15):2954–2962CrossRef
Metadaten
Titel
Survey of the management of perioperative bridging of anticoagulation and antiplatelet therapy in neurosurgery
verfasst von
Marco Skardelly
Lisa Mönch
Constantin Roder
Konstantin Hockel
Marcos Soares Tatagiba
Florian H. Ebner
Publikationsdatum
20.09.2018
Verlag
Springer Vienna
Erschienen in
Acta Neurochirurgica / Ausgabe 11/2018
Print ISSN: 0001-6268
Elektronische ISSN: 0942-0940
DOI
https://doi.org/10.1007/s00701-018-3679-5

Weitere Artikel der Ausgabe 11/2018

Acta Neurochirurgica 11/2018 Zur Ausgabe

Original Article - Neurosurgical technique evaluation

Telemetry in intracranial pressure monitoring: sensor survival and drift

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.