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Erschienen in: Journal of Neural Transmission 9/2008

01.09.2008 | Basic Neurosciences, Genetics and Immunology - Original Article

Investigation of the functional brain-derived neurotrophic factor gene variant Val66MET in migraine

verfasst von: Martin Marziniak, Andrea Herzog, Rainald Mössner, Claudia Sommer

Erschienen in: Journal of Neural Transmission | Ausgabe 9/2008

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Abstract

Experimental studies and investigations of the cerebrospinal fluid in migraineurs have suggested an involvement of brain-derived neurotrophic factor (BDNF) in migraine pathophysiology. In a case–control study approach, the functional Val66MET polymorphism (rs6265) of the BDNF gene was investigated in 265 migraine patients and 153 controls. Genotype and allele frequencies did not differ between healthy subjects and migraineurs. A subgroup analysis for the occurrence of aura or clinical characteristics, including the number of attacks, did not reveal a positive association for the investigated polymorphism. Our data argue against a role of this well characterized BDNF gene variant as a risk factor in migraine.
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Metadaten
Titel
Investigation of the functional brain-derived neurotrophic factor gene variant Val66MET in migraine
verfasst von
Martin Marziniak
Andrea Herzog
Rainald Mössner
Claudia Sommer
Publikationsdatum
01.09.2008
Verlag
Springer Vienna
Erschienen in
Journal of Neural Transmission / Ausgabe 9/2008
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI
https://doi.org/10.1007/s00702-008-0056-1

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