Skip to main content
Erschienen in: Journal of Neural Transmission 11/2012

01.11.2012 | Biological Psychiatry - Original Article

Indicators for elevated risk factors for alcohol-withdrawal seizures: an analysis using a random forest algorithm

verfasst von: Thomas Hillemacher, Helge Frieling, Julia Wilhelm, Annemarie Heberlein, Deniz Karagülle, Stefan Bleich, Bernd Lenz, Johannes Kornhuber

Erschienen in: Journal of Neural Transmission | Ausgabe 11/2012

Einloggen, um Zugang zu erhalten

Abstract

Alcohol-withdrawal seizures (AWS) are an important and relevant complication during detoxification in alcohol-dependent patients. Therefore, it is important to evaluate the individual risk for AWS. We apply a random forest algorithm to assess possible predictive markers in a large sample of 200 alcohol-dependent patients undergoing alcohol withdrawal. This analysis showed that the combination of homocysteine, prolactin, blood alcohol concentration on admission, number of preceding withdrawals, age and the number of cigarettes smoked may successfully predict AWS. In conclusion, the results of this analysis allow for origination of further research, which should include additional biological and psychosocial parameters as well as consumption behaviour.
Literatur
Zurück zum Zitat Alpaydin E (2008) Maschinelles Lernen. Oldenbourg Wissenschaftsverlag GmbH, Munich Alpaydin E (2008) Maschinelles Lernen. Oldenbourg Wissenschaftsverlag GmbH, Munich
Zurück zum Zitat Anzola GP (1993) Predictivity of plasma prolactin levels in differentiating epilepsy from pseudoseizures: a prospective study. Epilepsia 34:1044–1048PubMedCrossRef Anzola GP (1993) Predictivity of plasma prolactin levels in differentiating epilepsy from pseudoseizures: a prospective study. Epilepsia 34:1044–1048PubMedCrossRef
Zurück zum Zitat Bayerlein K, Hillemacher T, Reulbach U, Mugele B, Sperling W, Kornhuber J, Bleich S (2005) Alcoholism-associated hyperhomocysteinemia and previous withdrawal seizures. Biol Psychiatry 57:1590–1593PubMedCrossRef Bayerlein K, Hillemacher T, Reulbach U, Mugele B, Sperling W, Kornhuber J, Bleich S (2005) Alcoholism-associated hyperhomocysteinemia and previous withdrawal seizures. Biol Psychiatry 57:1590–1593PubMedCrossRef
Zurück zum Zitat Becker HC, Hale RL (1993) Repeated episodes of ethanol withdrawal potentiate the severity of subsequent withdrawal seizures: an animal model of alcohol withdrawal “kindling”. Alcohol Clin Exp Res 17:94–98PubMedCrossRef Becker HC, Hale RL (1993) Repeated episodes of ethanol withdrawal potentiate the severity of subsequent withdrawal seizures: an animal model of alcohol withdrawal “kindling”. Alcohol Clin Exp Res 17:94–98PubMedCrossRef
Zurück zum Zitat Bisiani R (1987) Beam search. In: Shapiro S, Eckroth D (eds) Encyclopedia of artificial intelligence. Wiley, New York, pp 56–58 Bisiani R (1987) Beam search. In: Shapiro S, Eckroth D (eds) Encyclopedia of artificial intelligence. Wiley, New York, pp 56–58
Zurück zum Zitat Bleich S, Hillemacher T (2009) Homocysteine, alcoholism and its molecular networks. Pharmacopsychiatry 42(Suppl 1):S102–S109PubMedCrossRef Bleich S, Hillemacher T (2009) Homocysteine, alcoholism and its molecular networks. Pharmacopsychiatry 42(Suppl 1):S102–S109PubMedCrossRef
Zurück zum Zitat Bleich S, Degner D, Bandelow B, von Ahsen N, Rüther E, Kornhuber J (2000) Plasma homocysteine is a predictor of alcohol withdrawal seizures. NeuroReport 11:2749–2752PubMedCrossRef Bleich S, Degner D, Bandelow B, von Ahsen N, Rüther E, Kornhuber J (2000) Plasma homocysteine is a predictor of alcohol withdrawal seizures. NeuroReport 11:2749–2752PubMedCrossRef
Zurück zum Zitat Bleich S, Degner D, Sperling W, Bönsch D, Thürauf N, Kornhuber J (2004) Homocysteine as a neurotoxin in chronic alcoholism. Prog Neuropsychopharmacol Biol Psychiatry 28:453–464PubMedCrossRef Bleich S, Degner D, Sperling W, Bönsch D, Thürauf N, Kornhuber J (2004) Homocysteine as a neurotoxin in chronic alcoholism. Prog Neuropsychopharmacol Biol Psychiatry 28:453–464PubMedCrossRef
Zurück zum Zitat Bleich S, Carl M, Bayerlein K, Reulbach U, Biermann T, Hillemacher T, Bönsch D, Kornhuber J (2005) Evidence of increased homocysteine levels in alcoholism: the Franconian alcoholism research studies (FARS). Alcohol Clin Exp Res 29:334–336PubMedCrossRef Bleich S, Carl M, Bayerlein K, Reulbach U, Biermann T, Hillemacher T, Bönsch D, Kornhuber J (2005) Evidence of increased homocysteine levels in alcoholism: the Franconian alcoholism research studies (FARS). Alcohol Clin Exp Res 29:334–336PubMedCrossRef
Zurück zum Zitat Bleich S, Bayerlein K, Hillemacher T, Degner D, Kornhuber J, Frieling H (2006) An assessment of the potential value of elevated homocysteine in predicting alcohol-withdrawal seizures. Epilepsia 47:934–938PubMedCrossRef Bleich S, Bayerlein K, Hillemacher T, Degner D, Kornhuber J, Frieling H (2006) An assessment of the potential value of elevated homocysteine in predicting alcohol-withdrawal seizures. Epilepsia 47:934–938PubMedCrossRef
Zurück zum Zitat Booth BM, Blow FC (1993) The kindling hypothesis: further evidence from a U.S. national study of alcoholic men. Alcohol Alcohol 28:593–598PubMed Booth BM, Blow FC (1993) The kindling hypothesis: further evidence from a U.S. national study of alcoholic men. Alcohol Alcohol 28:593–598PubMed
Zurück zum Zitat Brathen G, Bjerve KS, Brodtkorb E, Bovim G (2000) Validity of carbohydrate deficient transferrin and other markers as diagnostic aids in the detection of alcohol related seizures. J Neurol Neurosurg Psychiatry 68:342–348PubMedCrossRef Brathen G, Bjerve KS, Brodtkorb E, Bovim G (2000) Validity of carbohydrate deficient transferrin and other markers as diagnostic aids in the detection of alcohol related seizures. J Neurol Neurosurg Psychiatry 68:342–348PubMedCrossRef
Zurück zum Zitat Brown ME, Anton RF, Malcolm R, Ballenger JC (1988) Alcohol detoxification and withdrawal seizures: clinical support for a kindling hypothesis. Biol Psychiatry 23:507–514PubMedCrossRef Brown ME, Anton RF, Malcolm R, Ballenger JC (1988) Alcohol detoxification and withdrawal seizures: clinical support for a kindling hypothesis. Biol Psychiatry 23:507–514PubMedCrossRef
Zurück zum Zitat DiFranza JR, Guerrera MP (1990) Alcoholism and smoking. J Stud Alcohol 51:130–135PubMed DiFranza JR, Guerrera MP (1990) Alcoholism and smoking. J Stud Alcohol 51:130–135PubMed
Zurück zum Zitat Dworetzky BA, Bromfield EB, Townsend MK, Kang JH (2010) A prospective study of smoking, caffeine, and alcohol as risk factors for seizures or epilepsy in young adult women: data from the Nurses’ Health Study II. Epilepsia 51:198–205PubMedCrossRef Dworetzky BA, Bromfield EB, Townsend MK, Kang JH (2010) A prospective study of smoking, caffeine, and alcohol as risk factors for seizures or epilepsy in young adult women: data from the Nurses’ Health Study II. Epilepsia 51:198–205PubMedCrossRef
Zurück zum Zitat Fagerström KO, Heatherton TF, Kozlowski LT (1990) Nicotine addiction and its assessment. Ear Nose Throat J 69:763–765PubMed Fagerström KO, Heatherton TF, Kozlowski LT (1990) Nicotine addiction and its assessment. Ear Nose Throat J 69:763–765PubMed
Zurück zum Zitat Hillemacher T, Bayerlein K, Wilhelm J, Reulbach U, Frieling H, Bönsch D, Kornhuber J, Bleich S (2005) Alteration of prolactin serum levels during alcohol withdrawal correlates with craving in female patients. Addict Biol 10:337–343PubMedCrossRef Hillemacher T, Bayerlein K, Wilhelm J, Reulbach U, Frieling H, Bönsch D, Kornhuber J, Bleich S (2005) Alteration of prolactin serum levels during alcohol withdrawal correlates with craving in female patients. Addict Biol 10:337–343PubMedCrossRef
Zurück zum Zitat Hillemacher T, Bayerlein K, Wilhelm J, Frieling H, Thürauf N, Ziegenbein M, Kornhuber J, Bleich S (2006) Nicotine dependence is associated with compulsive alcohol craving. Addiction 101:892–897PubMedCrossRef Hillemacher T, Bayerlein K, Wilhelm J, Frieling H, Thürauf N, Ziegenbein M, Kornhuber J, Bleich S (2006) Nicotine dependence is associated with compulsive alcohol craving. Addiction 101:892–897PubMedCrossRef
Zurück zum Zitat Hillemacher T, Bayerlein K, Frieling H, Wilhelm J, Ziegenbein M, Kornhuber J, Bleich S (2007a) Elevated prolactin serum levels and history of alcohol withdrawal seizures. J Psychiatr Res 41:702–706PubMedCrossRef Hillemacher T, Bayerlein K, Frieling H, Wilhelm J, Ziegenbein M, Kornhuber J, Bleich S (2007a) Elevated prolactin serum levels and history of alcohol withdrawal seizures. J Psychiatr Res 41:702–706PubMedCrossRef
Zurück zum Zitat Hillemacher T, Frieling H, Bayerlein K, Wilhelm J, Kornhuber J, Bleich S (2007b) Biological markers to predict previous alcohol withdrawal seizures: a risk assessment. J Neural Transm 114:151–154PubMedCrossRef Hillemacher T, Frieling H, Bayerlein K, Wilhelm J, Kornhuber J, Bleich S (2007b) Biological markers to predict previous alcohol withdrawal seizures: a risk assessment. J Neural Transm 114:151–154PubMedCrossRef
Zurück zum Zitat John U, Meyer C, Rumpf HJ, Hapke U (2003) Probabilities of alcohol high-risk drinking, abuse or dependence estimated on grounds of tobacco smoking and nicotine dependence. Addiction 98:805–814PubMedCrossRef John U, Meyer C, Rumpf HJ, Hapke U (2003) Probabilities of alcohol high-risk drinking, abuse or dependence estimated on grounds of tobacco smoking and nicotine dependence. Addiction 98:805–814PubMedCrossRef
Zurück zum Zitat Karagülle D, Heberlein A, Wilhelm J, Frieling H, Kornhuber J, Bleich S, Hillemacher T (2012) CDT and homocysteine as predictors for alcohol withdrawal seizures. Eur Addict Res 18:97–102PubMedCrossRef Karagülle D, Heberlein A, Wilhelm J, Frieling H, Kornhuber J, Bleich S, Hillemacher T (2012) CDT and homocysteine as predictors for alcohol withdrawal seizures. Eur Addict Res 18:97–102PubMedCrossRef
Zurück zum Zitat Kissack JC, Bishop J, Roper AL (2008) Ethylglucuronide as a biomarker for ethanol detection. Pharmacotherapy 28:769–781PubMedCrossRef Kissack JC, Bishop J, Roper AL (2008) Ethylglucuronide as a biomarker for ethanol detection. Pharmacotherapy 28:769–781PubMedCrossRef
Zurück zum Zitat Li X, Breteler MM, de Bruyne MC, Meinardi H, Hauser WA, Hofman A (1997) Vascular determinants of epilepsy: the Rotterdam Study. Epilepsia 38:1216–1220PubMedCrossRef Li X, Breteler MM, de Bruyne MC, Meinardi H, Hauser WA, Hofman A (1997) Vascular determinants of epilepsy: the Rotterdam Study. Epilepsia 38:1216–1220PubMedCrossRef
Zurück zum Zitat Mierswa I, Wurst M, Klinkenberg R, Scholz M, Euler T (2006) YALE: rapid prototyping for complex data mining tasks. In: Proceedings of the 12th ACM SIGKDD international PONZETTO and STRUBE conference on knowledge discovery and data mining Mierswa I, Wurst M, Klinkenberg R, Scholz M, Euler T (2006) YALE: rapid prototyping for complex data mining tasks. In: Proceedings of the 12th ACM SIGKDD international PONZETTO and STRUBE conference on knowledge discovery and data mining
Zurück zum Zitat Ramsay RE, Rowan AJ, Pryor FM (2004) Special considerations in treating the elderly patient with epilepsy. Neurology 62:S24–S29PubMedCrossRef Ramsay RE, Rowan AJ, Pryor FM (2004) Special considerations in treating the elderly patient with epilepsy. Neurology 62:S24–S29PubMedCrossRef
Zurück zum Zitat Roecker EB (1991) Prediction error and its estimation for subset-selected models. Technometrics 33:459–468CrossRef Roecker EB (1991) Prediction error and its estimation for subset-selected models. Technometrics 33:459–468CrossRef
Zurück zum Zitat So EL, Annegers JF, Hauser WA, O’Brien PC, Whisnant JP (1996) Population-based study of seizure disorders after cerebral infarction. Neurology 46:350–355PubMedCrossRef So EL, Annegers JF, Hauser WA, O’Brien PC, Whisnant JP (1996) Population-based study of seizure disorders after cerebral infarction. Neurology 46:350–355PubMedCrossRef
Zurück zum Zitat Svetnik V, Liaw A, Tong C, Culberson JC, Sheridan RP, Feuston BP (2003) Random forest: a classification and regression tool for compound classification and QSAR modeling. J Chem Inf Comput Sci 43:1947–1958PubMedCrossRef Svetnik V, Liaw A, Tong C, Culberson JC, Sheridan RP, Feuston BP (2003) Random forest: a classification and regression tool for compound classification and QSAR modeling. J Chem Inf Comput Sci 43:1947–1958PubMedCrossRef
Zurück zum Zitat Tsai G, Coyle JT (1998) The role of glutamatergic neurotransmission in the pathophysiology of alcoholism. Annu Rev Med 49:173–184PubMedCrossRef Tsai G, Coyle JT (1998) The role of glutamatergic neurotransmission in the pathophysiology of alcoholism. Annu Rev Med 49:173–184PubMedCrossRef
Zurück zum Zitat Wallace H, Shorvon S, Tallis R (1998) Age-specific incidence and prevalence rates of treated epilepsy in an unselected population of 2,052,922 and age-specific fertility rates of women with epilepsy. Lancet 352:1970–1973PubMedCrossRef Wallace H, Shorvon S, Tallis R (1998) Age-specific incidence and prevalence rates of treated epilepsy in an unselected population of 2,052,922 and age-specific fertility rates of women with epilepsy. Lancet 352:1970–1973PubMedCrossRef
Zurück zum Zitat Witten IH, Frank E (2005) Data mining. Practical machine learning tools and techniques. Elsevier, Amsterdam Witten IH, Frank E (2005) Data mining. Practical machine learning tools and techniques. Elsevier, Amsterdam
Zurück zum Zitat Zacny JP (1990) Behavioral aspects of alcohol–tobacco interactions. Recent Dev Alcohol 8:205–219PubMed Zacny JP (1990) Behavioral aspects of alcohol–tobacco interactions. Recent Dev Alcohol 8:205–219PubMed
Zurück zum Zitat Zhou ZH (2009) Ensemble learning. In: Li SZ (ed) Encyclopedia of biometrics. Springer, Berlin, pp 270–273 Zhou ZH (2009) Ensemble learning. In: Li SZ (ed) Encyclopedia of biometrics. Springer, Berlin, pp 270–273
Metadaten
Titel
Indicators for elevated risk factors for alcohol-withdrawal seizures: an analysis using a random forest algorithm
verfasst von
Thomas Hillemacher
Helge Frieling
Julia Wilhelm
Annemarie Heberlein
Deniz Karagülle
Stefan Bleich
Bernd Lenz
Johannes Kornhuber
Publikationsdatum
01.11.2012
Verlag
Springer Vienna
Erschienen in
Journal of Neural Transmission / Ausgabe 11/2012
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI
https://doi.org/10.1007/s00702-012-0825-8

Weitere Artikel der Ausgabe 11/2012

Journal of Neural Transmission 11/2012 Zur Ausgabe

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Neu im Fachgebiet Neurologie

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.