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Journal of Neural Transmission

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01.12.2012 | Dementias - Short communication

Nigral Tau pathology and striatal amyloid-β deposition does not correlate with striatal dopamine deficit in Alzheimer’s disease

verfasst von: Tabea H. Schauer, Maximilian Lochner, Gabor G. Kovacs

Erschienen in: Journal of Neural Transmission | Ausgabe 12/2012

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Abstract

Extrapyramidal symptoms may appear in Alzheimer’s disease (AD). In the present study, using morphometric immunohistochemistry in 34 cases with AD-related pathology, we evaluated whether nigral burden of tau pathology or striatal burden of amyloid-β deposition correlates with dopamine transporter (DAT) expression in the striatum. Our observations show a lack of correlation between these variables and support the notion that lower striatal DAT expression in AD patients suggests concomitant nigral α-synuclein pathology. Extrapyramidal symptoms may have a complex background in AD.

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Titel: Nigral Tau pathology and striatal amyloid-β deposition does not correlate with striatal dopamine deficit in Alzheimer’s disease
verfasst von: Tabea H. Schauer
Maximilian Lochner
Gabor G. Kovacs
Publikationsdatum: 01.12.2012
Verlag: Springer Vienna
Erschienen in: Journal of Neural Transmission / Ausgabe 12/2012
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-012-0832-9

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