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Erschienen in: Journal of Neural Transmission 6/2013

01.06.2013 | Translational Neurosciences - Original Article

Do MAO A and MAO B utilize the same mechanism for the C–H bond cleavage step in catalysis? Evidence suggesting differing mechanisms

verfasst von: R. Orru, M. Aldeco, D. E. Edmondson

Erschienen in: Journal of Neural Transmission | Ausgabe 6/2013

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Abstract

The detailed molecular mechanism proposed for the MAO-catalyzed oxidation of amines has been controversial with the basic assumption that both MAO A and MAO B follow the same pathway for the C–H bond cleavage step. Using the mechanistic approach of investigation of electronic effects of various benzylamine ring substituents in experiments at pH 9.0, human MAO A exhibits a kinetic behavior characteristic of an H+ abstraction, while human MAO B exhibits kinetic properties characteristic of a H abstraction. These results lead to the conclusion that the assumption that MAO A and MAO B follow identical mechanisms is incorrect.
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Metadaten
Titel
Do MAO A and MAO B utilize the same mechanism for the C–H bond cleavage step in catalysis? Evidence suggesting differing mechanisms
verfasst von
R. Orru
M. Aldeco
D. E. Edmondson
Publikationsdatum
01.06.2013
Verlag
Springer Vienna
Erschienen in
Journal of Neural Transmission / Ausgabe 6/2013
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI
https://doi.org/10.1007/s00702-013-0991-3

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