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30.04.2016 | Psychiatry and Preclinical Psychiatric Studies - Original Article

Ventral medial prefrontal cortex (vmPFC) as a target of the dorsolateral prefrontal modulation by transcranial direct current stimulation (tDCS) in drug addiction

verfasst von: Ester Miyuki Nakamura-Palacios, Isabela Bittencourt Coutinho Lopes, Rodolpho Albuquerque Souza, Jaisa Klauss, Edson Kruger Batista, Catarine Lima Conti, Janine Andrade Moscon, Rodrigo Stênio Moll de Souza

Erschienen in: Journal of Neural Transmission | Ausgabe 10/2016

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Abstract

Here, we report some electrophysiologic and imaging effects of the transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (dlPFC) in drug addiction, notably in alcohol and crack-cocaine dependence. The low resolution electromagnetic tomography (LORETA) analysis obtained through event-related potentials (ERPs) under drug-related cues, more specifically in its P3 segment (300–500 ms) in both, alcoholics and crack-cocaine users, showed that the ventral medial prefrontal cortex (vmPFC) was the brain area with the largest change towards increasing activation under drug-related cues in those subjects that kept abstinence during and after the treatment with bilateral tDCS (2 mA, 35 cm², cathodal left and anodal right) over dlPFC, applied repetitively (five daily sessions). In an additional study in crack-cocaine, which showed craving decreases after repetitive bilateral tDCS, we examined data originating from diffusion tensor imaging (DTI), and we found increased DTI parameters in the left connection between vmPFC and nucleus accumbens (NAcc), such as the number of voxels, fractional anisotropy (FA) and apparent diffusion coefficient (ADC), in tDCS-treated crack-cocaine users when compared to the sham-tDCS group. This increasing of DTI parameters was significantly correlated with craving decreasing after the repetitive tDCS. The vmPFC relates to the control of drug seeking, possibly by extinguishing this behavior. In our studies, the bilateral dlPFC tDCS reduced relapses and craving to the drug use, and increased the vmPFC activation under drug cues, which may be of a great importance in the control of drug use in drug addiction.

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Titel: Ventral medial prefrontal cortex (vmPFC) as a target of the dorsolateral prefrontal modulation by transcranial direct current stimulation (tDCS) in drug addiction
verfasst von: Ester Miyuki Nakamura-Palacios
Isabela Bittencourt Coutinho Lopes
Rodolpho Albuquerque Souza
Jaisa Klauss
Edson Kruger Batista
Catarine Lima Conti
Janine Andrade Moscon
Rodrigo Stênio Moll de Souza
Publikationsdatum: 30.04.2016
Verlag: Springer Vienna
Erschienen in: Journal of Neural Transmission / Ausgabe 10/2016
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-016-1559-9

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Ventral medial prefrontal cortex (vmPFC) as a target of the dorsolateral prefrontal modulation by transcranial direct current stimulation (tDCS) in drug addiction

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