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Erschienen in: Archives of Virology 11/2008

01.11.2008 | Brief Report

Prevalence of hepatitis B virus genotypes in chronic carriers in Santiago, Chile

verfasst von: Mauricio Venegas, Gabriela Muñoz, Carmen Hurtado, Luis Alvarez, Marta Velasco, Rodrigo A. Villanueva, Javier Brahm

Erschienen in: Archives of Virology | Ausgabe 11/2008

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Abstract

The eight genotypes (designated A–H) of hepatitis B virus (HBV) display distinctive geographical distribution worldwide, with genotypes A, D and F frequently detected in South America. To determine the prevalence of HBV genotypes in Santiago, Chile, 131 samples from chronic carriers were used for PCR amplification, and genotyping was performed by RFLP. The results indicated that genotype F was the most prevalent among HBV carries (84% of the cases), whereas genotypes A, B, C and D were found at a prevalence of 3.8, 3.8, 6.1, and 2.3%, respectively. We discuss these data in the complex scenario of HBV epidemiology.
Literatur
1.
Zurück zum Zitat Arauz-Ruiz P, Norder H, Robertson BH, Magnius LO (2002) Genotype H: a new Amerindian genotype of hepatitis B virus revealed in Central America. J Gen Virol 83:2059–2073PubMed Arauz-Ruiz P, Norder H, Robertson BH, Magnius LO (2002) Genotype H: a new Amerindian genotype of hepatitis B virus revealed in Central America. J Gen Virol 83:2059–2073PubMed
2.
Zurück zum Zitat Bartholomeusz A, Schaefer S (2004) Hepatitis B virus genotypes: comparison of genotyping methods. Rev Med Virol 14:3–16PubMedCrossRef Bartholomeusz A, Schaefer S (2004) Hepatitis B virus genotypes: comparison of genotyping methods. Rev Med Virol 14:3–16PubMedCrossRef
3.
Zurück zum Zitat Buti M, Elefsiniotis I, Jardi R, Vargas V, Rodriguez-Frias F, Schapper M, Bonovas S, Esteban R (2007) Viral genotype and baseline load predict the response to adefovir treatment in lamivudine-resistant chronic hepatitis B patients. J Hepatol 47:366–372PubMedCrossRef Buti M, Elefsiniotis I, Jardi R, Vargas V, Rodriguez-Frias F, Schapper M, Bonovas S, Esteban R (2007) Viral genotype and baseline load predict the response to adefovir treatment in lamivudine-resistant chronic hepatitis B patients. J Hepatol 47:366–372PubMedCrossRef
4.
Zurück zum Zitat Devesa M, Pujol FH (2007) Hepatitis B virus genetic diversity in Latin America. Virus Res 127:177–184PubMedCrossRef Devesa M, Pujol FH (2007) Hepatitis B virus genetic diversity in Latin America. Virus Res 127:177–184PubMedCrossRef
5.
Zurück zum Zitat Devesa M, Loureiro CL, Rivas Y, Monsalve F, Cardona N, Duarte MC, Poblete F, Gutierrez MF, Botto C, Pujol FH (2008) Subgenotype diversity of hepatitis B virus American genotype F in Amerindians from Venezuela and the general population of Colombia. J Med Virol 80:20–26PubMedCrossRef Devesa M, Loureiro CL, Rivas Y, Monsalve F, Cardona N, Duarte MC, Poblete F, Gutierrez MF, Botto C, Pujol FH (2008) Subgenotype diversity of hepatitis B virus American genotype F in Amerindians from Venezuela and the general population of Colombia. J Med Virol 80:20–26PubMedCrossRef
6.
Zurück zum Zitat Flink HJ, van Zonneveld M, Hansen BE, de Man RA, Schalm SW, Janssen HL (2006) Treatment with Peg-interferon alpha-2b for HBeAg-positive chronic hepatitis B: HBsAg loss is associated with HBV genotype. Am J Gastroenterol 101:297–303PubMedCrossRef Flink HJ, van Zonneveld M, Hansen BE, de Man RA, Schalm SW, Janssen HL (2006) Treatment with Peg-interferon alpha-2b for HBeAg-positive chronic hepatitis B: HBsAg loss is associated with HBV genotype. Am J Gastroenterol 101:297–303PubMedCrossRef
7.
Zurück zum Zitat Fung SK, Lok AS (2004) Hepatitis B virus genotypes: do they play a role in the outcome of HBV infection? Hepatology 40:790–792PubMed Fung SK, Lok AS (2004) Hepatitis B virus genotypes: do they play a role in the outcome of HBV infection? Hepatology 40:790–792PubMed
8.
Zurück zum Zitat Jiron MI, Armas-Merino R, Soto JR, Vargas-Tank L, Lobo G, Pacheco J, Wolff C (1983) Serum markers of hepatitis B virus in chronic active hepatitis. Rev Med Chil 111:463–465PubMed Jiron MI, Armas-Merino R, Soto JR, Vargas-Tank L, Lobo G, Pacheco J, Wolff C (1983) Serum markers of hepatitis B virus in chronic active hepatitis. Rev Med Chil 111:463–465PubMed
9.
Zurück zum Zitat Khan A, Tanaka Y, Saito H, Ebinuma H, Sekiguchi H, Iwama H, Wakabayashi G, Kamiya T, Kurbanov F, Elkady A, Mizokami M (2008) Transmission of hepatitis B virus (HBV) genotypes among Japanese immigrants and natives in Bolivia. Virus Res 132:174–180PubMedCrossRef Khan A, Tanaka Y, Saito H, Ebinuma H, Sekiguchi H, Iwama H, Wakabayashi G, Kamiya T, Kurbanov F, Elkady A, Mizokami M (2008) Transmission of hepatitis B virus (HBV) genotypes among Japanese immigrants and natives in Bolivia. Virus Res 132:174–180PubMedCrossRef
10.
11.
Zurück zum Zitat Livingston SE, Simonetti JP, Bulkow LR, Homan CE, Snowball MM, Cagle HH, Negus SE, McMahon BJ (2007) Clearance of hepatitis B e antigen in patients with chronic hepatitis B and genotypes A, B, C, D, and F. Gastroenterology 133:1452–1457PubMedCrossRef Livingston SE, Simonetti JP, Bulkow LR, Homan CE, Snowball MM, Cagle HH, Negus SE, McMahon BJ (2007) Clearance of hepatitis B e antigen in patients with chronic hepatitis B and genotypes A, B, C, D, and F. Gastroenterology 133:1452–1457PubMedCrossRef
12.
Zurück zum Zitat Livingston SE, Simonetti JP, McMahon BJ, Bulkow LR, Hurlburt KJ, Homan CE, Snowball MM, Cagle HH, Williams JL, Chulanov VP (2007) Hepatitis B virus genotypes in Alaska Native people with hepatocellular carcinoma: preponderance of genotype F. J Infect Dis 195:5–11PubMedCrossRef Livingston SE, Simonetti JP, McMahon BJ, Bulkow LR, Hurlburt KJ, Homan CE, Snowball MM, Cagle HH, Williams JL, Chulanov VP (2007) Hepatitis B virus genotypes in Alaska Native people with hepatocellular carcinoma: preponderance of genotype F. J Infect Dis 195:5–11PubMedCrossRef
13.
Zurück zum Zitat Mello FC, Souto FJ, Nabuco LC, Villela-Nogueira CA, Coelho HS, Franz HC, Saraiva JC, Virgolino HA, Motta-Castro AR, Melo MM, Martins RM, Gomes SA (2007) Hepatitis B virus genotypes circulating in Brazil: molecular characterization of genotype F isolates. BMC Microbiol 7:103PubMedCrossRef Mello FC, Souto FJ, Nabuco LC, Villela-Nogueira CA, Coelho HS, Franz HC, Saraiva JC, Virgolino HA, Motta-Castro AR, Melo MM, Martins RM, Gomes SA (2007) Hepatitis B virus genotypes circulating in Brazil: molecular characterization of genotype F isolates. BMC Microbiol 7:103PubMedCrossRef
14.
Zurück zum Zitat Norder H, Courouce AM, Magnius LO (1994) Complete genomes, phylogenetic relatedness, and structural proteins of six strains of the hepatitis B virus, four of which represent two new genotypes. Virology 198:489–503PubMedCrossRef Norder H, Courouce AM, Magnius LO (1994) Complete genomes, phylogenetic relatedness, and structural proteins of six strains of the hepatitis B virus, four of which represent two new genotypes. Virology 198:489–503PubMedCrossRef
15.
Zurück zum Zitat Orito E, Mizokami M, Sakugawa H, Michitaka K, Ishikawa K, Ichida T, Okanoue T, Yotsuyanagi H, Iino S (2001) A case-control study for clinical and molecular biological differences between hepatitis B viruses of genotypes B and C. Japan HBV Genotype Research Group. Hepatology 33:218–223PubMedCrossRef Orito E, Mizokami M, Sakugawa H, Michitaka K, Ishikawa K, Ichida T, Okanoue T, Yotsuyanagi H, Iino S (2001) A case-control study for clinical and molecular biological differences between hepatitis B viruses of genotypes B and C. Japan HBV Genotype Research Group. Hepatology 33:218–223PubMedCrossRef
16.
Zurück zum Zitat Osiowy C, Giles E (2003) Evaluation of the INNO-LiPA HBV genotyping assay for determination of hepatitis B virus genotype. J Clin Microbiol 41:5473–5477PubMedCrossRef Osiowy C, Giles E (2003) Evaluation of the INNO-LiPA HBV genotyping assay for determination of hepatitis B virus genotype. J Clin Microbiol 41:5473–5477PubMedCrossRef
17.
Zurück zum Zitat Pereira SA, MT Valenzuela B, Mora J, Vera L (2008) Present situation of hepatitis B in Chile. Rev Med Chil 136:725–732 Pereira SA, MT Valenzuela B, Mora J, Vera L (2008) Present situation of hepatitis B in Chile. Rev Med Chil 136:725–732
18.
Zurück zum Zitat Piñeiro Y Leone FG, Pezzano SC, Torres C, Rodríguez CE, Eugenia Garay M, Fainboim HA, Remondegui C, Sorrentino AP, Mbayed VA, Campos RH (2008) Hepatitis B virus genetic diversity in Argentina: dissimilar genotype distribution in two different geographical regions; description of hepatitis B surface antigen variants. J Clin Virol 42:381–388 Piñeiro Y Leone FG, Pezzano SC, Torres C, Rodríguez CE, Eugenia Garay M, Fainboim HA, Remondegui C, Sorrentino AP, Mbayed VA, Campos RH (2008) Hepatitis B virus genetic diversity in Argentina: dissimilar genotype distribution in two different geographical regions; description of hepatitis B surface antigen variants. J Clin Virol 42:381–388
19.
Zurück zum Zitat Sanchez-Tapias JM, Costa J, Mas A, Bruguera M, Rodes J (2002) Influence of hepatitis B virus genotype on the long-term outcome of chronic hepatitis B in western patients. Gastroenterology 123:1848–1856PubMedCrossRef Sanchez-Tapias JM, Costa J, Mas A, Bruguera M, Rodes J (2002) Influence of hepatitis B virus genotype on the long-term outcome of chronic hepatitis B in western patients. Gastroenterology 123:1848–1856PubMedCrossRef
20.
Zurück zum Zitat Schaefer S (2005) Hepatitis B virus taxonomy and hepatitis B virus genotypes. World J Gastroenterol 13:14–21 Schaefer S (2005) Hepatitis B virus taxonomy and hepatitis B virus genotypes. World J Gastroenterol 13:14–21
21.
Zurück zum Zitat Stuyver L, De Gendt S, Van Geyt C, Zoulim F, Fried M, Schinazi RF, Rossau R (2000) A new genotype of hepatitis B virus: complete genome and phylogenetic relatedness. J Gen Virol 81:67–74PubMed Stuyver L, De Gendt S, Van Geyt C, Zoulim F, Fried M, Schinazi RF, Rossau R (2000) A new genotype of hepatitis B virus: complete genome and phylogenetic relatedness. J Gen Virol 81:67–74PubMed
22.
Zurück zum Zitat Thakur V, Guptan RC, Kazim SN, Malhotra V, Sarin SK (2002) Profile, spectrum and significance of HBV genotypes in chronic liver disease patients in the Indian subcontinent. J Gastroenterol Hepatol 17:165–170PubMedCrossRef Thakur V, Guptan RC, Kazim SN, Malhotra V, Sarin SK (2002) Profile, spectrum and significance of HBV genotypes in chronic liver disease patients in the Indian subcontinent. J Gastroenterol Hepatol 17:165–170PubMedCrossRef
23.
Zurück zum Zitat Velasco M, Brahm J, Borgono JM, Concha E, Veit O, Zavala C (1984) Hepatitis B surface antigens (HBsAg) and anti-HBs antibodies in outpatients and hospital personnel. Rev Med Chil 112:994–997PubMed Velasco M, Brahm J, Borgono JM, Concha E, Veit O, Zavala C (1984) Hepatitis B surface antigens (HBsAg) and anti-HBs antibodies in outpatients and hospital personnel. Rev Med Chil 112:994–997PubMed
24.
Zurück zum Zitat von Meltzer M, Vásquez S, Sun J, Wendt UC, May A, Gerlich WH, Radtke M, Schaefer S (2008) A new clade of hepatitis B virus subgenotype F1 from Peru with unusual properties. Virus Genes 37:225–230CrossRef von Meltzer M, Vásquez S, Sun J, Wendt UC, May A, Gerlich WH, Radtke M, Schaefer S (2008) A new clade of hepatitis B virus subgenotype F1 from Peru with unusual properties. Virus Genes 37:225–230CrossRef
25.
Zurück zum Zitat Wai CT, Fontana RJ (2004) Clinical significance of hepatitis B virus genotypes, variants, and mutants. Clin Liver Dis 8:321–352, vi Wai CT, Fontana RJ (2004) Clinical significance of hepatitis B virus genotypes, variants, and mutants. Clin Liver Dis 8:321–352, vi
26.
Zurück zum Zitat Zeng GB, Wen SJ, Wang ZH, Yan L, Sun J, Hou JL (2004) A novel hepatitis B virus genotyping system by using restriction fragment length polymorphism patterns of S gene amplicons. World J Gastroenterol 10:3132–3136PubMed Zeng GB, Wen SJ, Wang ZH, Yan L, Sun J, Hou JL (2004) A novel hepatitis B virus genotyping system by using restriction fragment length polymorphism patterns of S gene amplicons. World J Gastroenterol 10:3132–3136PubMed
Metadaten
Titel
Prevalence of hepatitis B virus genotypes in chronic carriers in Santiago, Chile
verfasst von
Mauricio Venegas
Gabriela Muñoz
Carmen Hurtado
Luis Alvarez
Marta Velasco
Rodrigo A. Villanueva
Javier Brahm
Publikationsdatum
01.11.2008
Verlag
Springer Vienna
Erschienen in
Archives of Virology / Ausgabe 11/2008
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-008-0231-6

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