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Erschienen in: Archives of Virology 8/2012

01.08.2012 | Brief Review

The contribution of rodent models to the pathological assessment of flaviviral infections of the central nervous system

verfasst von: David C. Clark, Aaron C. Brault, Elizabeth Hunsperger

Erschienen in: Archives of Virology | Ausgabe 8/2012

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Abstract

Members of the genus Flavivirus are responsible for a spectrum of important neurological syndromes in humans and animals. Rodent models have been used extensively to model flavivirus neurological disease, to discover host-pathogen interactions that influence disease outcome, and as surrogates to determine the efficacy and safety of vaccines and therapeutics. In this review, we discuss the current understanding of flavivirus neuroinvasive disease and outline the host, viral and experimental factors that influence the outcome and reliability of virus infection of small-animal models.
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Metadaten
Titel
The contribution of rodent models to the pathological assessment of flaviviral infections of the central nervous system
verfasst von
David C. Clark
Aaron C. Brault
Elizabeth Hunsperger
Publikationsdatum
01.08.2012
Verlag
Springer Vienna
Erschienen in
Archives of Virology / Ausgabe 8/2012
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-012-1337-4

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