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Molecular evolution of the VP7 gene of Japanese G2 rotaviruses before vaccine introduction

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Abstract

Changes in the prevalence of G2 rotavirus after vaccine introduction are an important issue. However, such changes in a given country should be interpreted in the global context over time. We determined 35 Japanese G2 sequences and compared them with 508 globally collected G2 sequences. The D96N substitution, a substitution known to be associated with an abrupt increase in G2 strains and antigenic changes, emerged in those strains that formed a nascent lineage outside of the currently predominant lineage (sublineage IVa). Further studies are warranted to monitor the potential of their global spread, since they also appeared in Europe and Australia.

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Acknowledgments

We acknowledge Dr, Katsushima for providing some of the stool specimens containing G2 rotaviruses that were used in this study.

This study was supported in part by the Global Center of Excellence Program on Integrated Global Control Strategy for Tropical and Emerging Infectious Diseases from the Ministry of Education, Culture, Sports, Science and Technology, Japan. This study was also supported in part by a grant-in-aid for scientific research from the Ministry of Health, Labor, and Welfare, Japan.

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Authors and Affiliations

  1. Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan

    L. P. Do, T. Nakagomi, Y. H. Doan & O. Nakagomi

  2. Nara Prefectural Institute for Hygiene and Environment, Nara, Japan

    Y. Kitahori

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  1. L. P. Do
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  2. T. Nakagomi
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  3. Y. H. Doan
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  4. Y. Kitahori
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  5. O. Nakagomi
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Correspondence to O. Nakagomi.

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Do, L.P., Nakagomi, T., Doan, Y.H. et al. Molecular evolution of the VP7 gene of Japanese G2 rotaviruses before vaccine introduction. Arch Virol 159, 315–319 (2014). https://doi.org/10.1007/s00705-013-1804-6

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  • DOI: https://doi.org/10.1007/s00705-013-1804-6

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