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17.08.2017 | Original Article

Molecular characterization of atypical antigenic variants of canine rabies virus reveals its reintroduction by wildlife vectors in southeastern Mexico

verfasst von: Fabiola Garcés-Ayala, Nidia Aréchiga-Ceballos, Joanna M. Ortiz-Alcántara, Elizabeth González-Durán, Sandra I. Pérez-Agüeros, Alfonso Méndez-Tenorio, Belem Torres-Longoria, Irma López-Martínez, Lucía Hernández-Rivas, José Alberto Díaz-Quiñonez, José Ernesto Ramírez-González

Erschienen in: Archives of Virology | Ausgabe 12/2017

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Abstract

Rabies is an infectious viral disease that is practically always fatal following the onset of clinical signs. In Mexico, the last case of human rabies transmitted by dogs was reported in 2006 and canine rabies has declined significantly due to vaccination campaigns implemented in the country. Here we report on the molecular characterization of six rabies virus strains found in Yucatan and Chiapas, remarkably, four of them showed an atypical reaction pattern when antigenic characterization with a reduced panel of eight monoclonal antibodies was performed. Phylogenetic analyses on the RNA sequences unveiled that the three atypical strains from Yucatan are associated with skunks. Analysis using the virus entire genome showed that they belong to a different lineage distinct from the variants described for this animal species in Mexico. The Chiapas atypical strain was grouped in a lineage that was considered extinct, while the others are clustered within classic dog variants.

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Titel: Molecular characterization of atypical antigenic variants of canine rabies virus reveals its reintroduction by wildlife vectors in southeastern Mexico
verfasst von: Fabiola Garcés-Ayala
Nidia Aréchiga-Ceballos
Joanna M. Ortiz-Alcántara
Elizabeth González-Durán
Sandra I. Pérez-Agüeros
Alfonso Méndez-Tenorio
Belem Torres-Longoria
Irma López-Martínez
Lucía Hernández-Rivas
José Alberto Díaz-Quiñonez
José Ernesto Ramírez-González
Publikationsdatum: 17.08.2017
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 12/2017
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-017-3529-4

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Molecular characterization of atypical antigenic variants of canine rabies virus reveals its reintroduction by wildlife vectors in southeastern Mexico

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