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Archives of Virology

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21.11.2017 | Brief Report

Isolation and molecular characterization of an H5N1 swine influenza virus in China in 2015

verfasst von: Haibo Wu, Fan Yang, Rufeng Lu, Lihua Xu, Fumin Liu, Xiuming Peng, Nanping Wu

Erschienen in: Archives of Virology | Ausgabe 3/2018

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Abstract

In 2015, an H5N1 influenza virus was isolated from a pig in Zhejiang Province, Eastern China. This strain was characterized by whole-genome sequencing with subsequent phylogenetic analysis. Phylogenetic analysis showed that all segments from this strain belonged to clade 2.3.2 and that it had received its genes from poultry influenza viruses in China. A Glu627Lys mutation associated with pathogenicity was observed in the PB2 protein. This strain was moderately pathogenic in mice and was able to replicate without prior adaptation. These results suggest that active surveillance of swine influenza should be used as an early warning system for influenza outbreaks in mammals.

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WHO (2017) Cumulative number of confirmed human cases of avian influenza A(H5N1) reported to WHO. http://www.who.int/influenza/human_animal_interface/H5N1_cumulative_table_archives/en/. Accessed 22 Mar 2017

WHO (2014) WHO China statement on H5N6. http://www.wpro.who.int/china/mediacentre/releases/2014/20140507/en/. Accessed 26 Mar 2017

Ito T, Couceiro JN, Kelm S, Baum LG, Krauss S, Castrucci MR, Donatelli I, Kida H, Paulson JC, Webster RG, Kawaoka Y (1998) Molecular basis for the generation in pigs of influenza A viruses with pandemic potential. J Virol 72:7367–7373PubMedPubMedCentral

He L, Zhao G, Zhong L, Liu Q, Duan Z, Gu M, Wang X, Liu X (2013) Isolation and characterization of two H5N1 influenza viruses from swine in Jiangsu Province of China. Arch Virol 158:2531–2541CrossRefPubMed

Li X, Fu Y, Yang J, Guo J, He J, Weng S, Jia Y, Liu B, Zhu Q, Chen H (2015) Genetic and biological characterization of two novel reassortant H5N6 swine influenza viruses in mice and chickens. Infect Genet Evol 36:462–466CrossRefPubMed

Cong Y, Wang G, Guan Z, Chang S, Zhang Q, Yang G, Wang W, Meng Q, Ren W, Wang C, Ding Z (2010) Reassortant between human-Like H3N2 and avian H5 subtype influenza A viruses in pigs: a potential public health risk. PLoS One 5:e12591CrossRefPubMedPubMedCentral

Wu HB, Guo CT, Lu RF, Xu LH, Wo EK, You JB, Wang YT, Wang QG, Wu NP (2012) Genetic characterization of subtype H1 avian influenza viruses isolated from live poultry markets in Zhejiang Province, China, in 2011. Virus Genes 44:441–449CrossRefPubMed

Hoffmann E, Stech J, Guan Y, Webster RG, Perez DR (2001) Universal primer set for the full-length amplification of all influenza A viruses. Arch Virol 146:2275–2289CrossRefPubMed

Wong FY, Phommachanh P, Kalpravidh W, Chanthavisouk C, Gilbert J, Bingham J, Davies KR, Cooke J, Eagles D, Phiphakhavong S, Shan S, Stevens V, Williams DT, Bounma P, Khambounheuang B, Morrissy C, Douangngeun B, Morzaria S (2015) Reassortant highly pathogenic influenza A(H5N6) virus in Laos. Emerg Infect Dis 21:511–516CrossRefPubMedPubMedCentral

10.

Lee YJ, Kang HM, Lee EK, Song BM, Jeong J, Kwon YK, Kim HR, Lee KJ, Hong MS, Jang I, Choi KS, Kim JY, Lee HJ, Kang MS, Jeong OM, Baek JH, Joo YS, Park YH, Lee HS (2014) Novel reassortant influenza A(H5N8) viruses, South Korea, 2014. Emerg Infect Dis 20:1087–1089PubMedPubMedCentral

11.

Gu M, Liu W, Cao Y, Peng D, Wang X, Wan H, Zhao G, Xu Q, Zhang W, Song Q, Li Y, Liu X (2011) Novel reassortant highly pathogenic avian influenza (H5N5) viruses in domestic ducks, China. Emerg Infect Dis 17:1060–1063CrossRefPubMedPubMedCentral

12.

Tamura K, Stecher G, Peterson D, Filipski A, Kumar S (2013) MEGA6: molecular evolutionary genetics analysis version 6.0. Mol Biol Evol 30:2725–2729CrossRefPubMedPubMedCentral

13.

Hu X, Liu D, Wang M, Yang L, Zhu Q, Li L, Gao GF (2011) Clade 2.3.2 avian influenza virus (H5N1), Qinghai Lake region, China, 2009–2010. Emerg Infect Dis 17:560–562CrossRefPubMedPubMedCentral

14.

Hai-bo W, Chao-tan G, Ru-feng L, Li-hua X, En-kang W, Jin-biao Y, Yi-ting W, Qiao-gang W, Nan-ping W (2012) Characterization of a highly pathogenic H5N1 avian influenza virus isolated from ducks in Eastern China in 2011. Arch Virol 157:1131–1136CrossRefPubMed

15.

Wu H, Peng X, Cheng L, Lu X, Jin C, Xie T, Yao H, Wu N (2015) Genetic and molecular characterization of H9N2 and H5 avian influenza viruses from live poultry markets in Zhejiang Province, eastern China. Sci Rep 5:17508CrossRefPubMedPubMedCentral

16.

Horimoto T, Ito T, Alexander DJ, Kawaoka Y (1995) Cleavability of hemagglutinin from an extremely virulent strain of avian influenza virus containing a unique cleavage site sequence. J Vet Med Sci 57:927–930CrossRefPubMed

17.

Zhang Y, Zhu J, Li Y, Bradley KC, Cao J, Chen H, Jin M, Zhou H (2013) Glycosylation on hemagglutinin affects the virulence and pathogenicity of pandemic H1N1/2009 influenza A virus in mice. PLoS One 8:e61397CrossRefPubMedPubMedCentral

18.

Helenius A, Aebi M (2004) Roles of N-linked glycans in the endoplasmic reticulum. Annu Rev Biochem 73:1019–1049CrossRefPubMed

19.

Shinya K, Hamm S, Hatta M, Ito H, Ito T, Kawaoka Y (2004) PB2 amino acid at position 627 affects replicative efficiency, but not cell tropism, of Hong Kong H5N1 influenza A viruses in mice. Virology 320:258–266CrossRefPubMed

20.

Jiao P, Tian G, Li Y, Deng G, Jiang Y, Liu C, Liu W, Bu Z, Kawaoka Y, Chen H (2008) A single-amino-acid substitution in the NS1 protein changes the pathogenicity of H5N1 avian influenza viruses in mice. J Virol 82:1146–1154CrossRefPubMed

21.

Liu Q, Zhou B, Ma W, Bawa B, Ma J, Wang W, Lang Y, Lyoo Y, Halpin RA, Lin X, Stockwell TB, Webby R, Wentworth DE, Richt JA (2014) Analysis of recombinant H7N9 wild-type and mutant viruses in pigs shows that the Q226L mutation in HA is important for transmission. J Virol 88:8153–8165CrossRefPubMedPubMedCentral

22.

Jin H, Wang D, Sun J, Cui Y, Chen G, Zhang X, Zhang J, Li X, Chai H, Gao Y, Li Y, Hua Y (2016) Pathogenesis and phylogenetic analyses of two avian influenza H7N1 viruses isolated from wild birds. Front Microbiol 7:1066PubMedPubMedCentral

23.

Olsen B, Munster VJ, Wallensten A, Waldenstrom J, Osterhaus AD, Fouchier RA (2006) Global patterns of influenza a virus in wild birds. Science 312:384–388CrossRefPubMed

24.

Remschmidt C, Stocker P, an der Heiden M, Suess T, Luchtenberg M, Schink SB, Schweiger B, Haas W, Buchholz U (2013) Preventable and non-preventable risk factors for influenza transmission and hygiene behavior in German influenza households, pandemic season (H1N1) 2009/2010. Influenza Other Respi Viruses 7:418–425CrossRef

Titel: Isolation and molecular characterization of an H5N1 swine influenza virus in China in 2015
verfasst von: Haibo Wu
Fan Yang
Rufeng Lu
Lihua Xu
Fumin Liu
Xiuming Peng
Nanping Wu
Publikationsdatum: 21.11.2017
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 3/2018
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-017-3638-0

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Isolation and molecular characterization of an H5N1 swine influenza virus in China in 2015

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