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Erschienen in: Der Onkologe 10/2012

01.10.2012 | Leitthema

Prädiktive und prognostische Marker beim Endometriumkarzinom

verfasst von: PD Dr. E. Steiner, J. Einenkel, D. Schmidt, L.-C. Horn

Erschienen in: Die Onkologie | Ausgabe 10/2012

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Zusammenfassung

In den letzten Jahren haben zahlreiche Studien prognostische und prädiktive Parameter analysiert, die auch beim Endometriumkarzinom (EC) die operative und adjuvante Therapie zunehmend patientinnen- und tumoradaptiert gestalten. Therapeutisch relevant sind das klinische FIGO-Stadium, der histologische Tumortyp, das Grading, eine Zervixbeteiligung und der Nachweis einer lymphogenen Metastasierung. Neben diesen Faktoren haben auch der Nachweis einer Lymphgefäßinfiltration, die operative Radikalität, Alter und Adipositas prognostische Relevanz. Das Verständnis für die Pathogenese auf molekularer Ebene ist entscheidend für die Identifikation neuer prognoserelevanter Biomarker. Neue tumorbiologische Parameter und Genexpressionsanalysen identifizieren bereits verschiedene Typen beim endometroiden Adenokarzinom mit unterschiedlicher Prognose, jedoch reichen die Daten noch nicht für den klinischen Einsatz.
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Metadaten
Titel
Prädiktive und prognostische Marker beim Endometriumkarzinom
verfasst von
PD Dr. E. Steiner
J. Einenkel
D. Schmidt
L.-C. Horn
Publikationsdatum
01.10.2012
Verlag
Springer-Verlag
Erschienen in
Die Onkologie / Ausgabe 10/2012
Print ISSN: 2731-7226
Elektronische ISSN: 2731-7234
DOI
https://doi.org/10.1007/s00761-012-2289-8

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