Abstract
The reliability of analytical data is very important to forensic and clinical toxicologists for the correct interpretation of toxicological findings. This makes (bio)analytical method validation an integral part of quality management and accreditation in analytical toxicology. Therefore, consensus should be reached in this field on the kind and extent of validation experiments as well as on acceptance criteria for validation parameters. In this review, the most important papers published on this topic since 1991 have been reviewed. Terminology, theoretical and practical aspects as well as implications for forensic and clinical toxicology of the following validation parameters are discussed: selectivity (specificity), calibration model (linearity), accuracy, precision, limits, stability, recovery and ruggedness (robustness).
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 16 June 2002 Accepted: 12 July 2002
Part of this review was published in the communications of the International Association of Forensic Toxicologists (TIAFT; TIAFT Bulletin 32 (2002): 16–23) and of the Society for Forensic and Toxicologic Chemistry (GTFCH; Toxichem and Krimitech 68 (2001): 116-126).
Correspondence to F. T. Peters
Rights and permissions
About this article
Cite this article
Peters, F., Maurer, H. Bioanalytical method validation and its implications for forensic and clinical toxicology – A review. Accred Qual Assur 7, 441–449 (2002). https://doi.org/10.1007/s00769-002-0516-5
Issue Date:
DOI: https://doi.org/10.1007/s00769-002-0516-5