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Relationships between the insulin-like growth factor I (IGF-I) receptor gene G3174A polymorphism, serum IGF-I levels, and bone mineral density in postmenopausal Korean women

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Abstract

We investigated the relationships between the IGF-I receptor gene G3174A polymorphism, serum IGF-I levels, and bone mineral density (BMD) in postmenopausal Korean women. The IGF-I receptor gene G3174A polymorphism was analyzed in 367 postmenopausal Korean women. Serum levels of IGF-I, bone turnover markers (osteocalcin, bone alkaline phosphatase, carboxy-terminal cross-linking telopeptide of type I collagen), and BMD at the lumbar spine and proximal femur were measured. The frequencies of the AA, GA, and GG genotypes were 10.9%, 44.1%, and 45.0%, respectively. BMD at the lumbar spine was significantly higher for the AA genotype than the other genotypes and showed an A allelic dose effect; however, no significant differences in BMD were observed at the proximal femur with respect to genotype. No differences were noted between the three genotypes in terms of serum levels of IGF-I or bone turnover markers. Women with low BMD showed a lower prevalence of the AA genotype and A allele than age-matched women with normal BMD. Women with the AA genotype were found to have about half the risk of a low BMD than women with other genotypes. In conclusion, IGF-I receptor gene G3174A polymorphism is associated with lumbar spine BMD in postmenopausal Korean women.

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Authors and Affiliations

  1. National Cancer Center, Il-San, Korea

    Dong Ock Lee

  2. Department of Obstetrics & Gynecology, College of Medicine Seoul National University Hospital, 28 Yeungun-dong, Chongno-Ku, Seoul, 110-744, Korea

    Byung Chul Jee, Seung-Yup Ku, Chang Suk Suh, Seok Hyun Kim, Young Min Choi, Shin Yong Moon & Jung Gu Kim

  3. Clinical Research Institute, Seoul National University Hospital, Seoul, Korea

    Seung-Yup Ku, Chang Suk Suh, Seok Hyun Kim, Young Min Choi, Shin Yong Moon & Jung Gu Kim

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  1. Dong Ock Lee
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  2. Byung Chul Jee
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  3. Seung-Yup Ku
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  4. Chang Suk Suh
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  5. Seok Hyun Kim
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  6. Young Min Choi
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  7. Shin Yong Moon
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  8. Jung Gu Kim
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Correspondence to Jung Gu Kim.

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Lee, D., Jee, B., Ku, SY. et al. Relationships between the insulin-like growth factor I (IGF-I) receptor gene G3174A polymorphism, serum IGF-I levels, and bone mineral density in postmenopausal Korean women. J Bone Miner Metab 26, 42–46 (2008). https://doi.org/10.1007/s00774-007-0795-3

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  • DOI: https://doi.org/10.1007/s00774-007-0795-3

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