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Erschienen in: Clinical Oral Investigations 2/2013

01.03.2013 | Original Article

One-year results of vital pulp therapy in permanent molars with irreversible pulpitis: an ongoing multicenter, randomized, non-inferiority clinical trial

verfasst von: Saeed Asgary, Mohammad Jafar Eghbal, Jamileh Ghoddusi, Shahram Yazdani

Erschienen in: Clinical Oral Investigations | Ausgabe 2/2013

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Abstract

Objectives

Root canal therapy (RCT) and tooth extraction have been conventional treatment options for management of human mature teeth with irreversible pulpitis. Excellent short-term treatment outcomes of vital pulp therapy with calcium-enriched mixture cement (VPT/CEM), as a new treatment option, on postoperative pain relief was demonstrated; if intermediate- and long-term treatment outcomes of the new treatment are also non-inferior compared to RCT, then VPT/CEM may become a viable treatment option for management of mature teeth with irreversible pulpitis.

Materials and methods

In 23 healthcare centers, 407 9- to 65-year-old patients were randomly allocated into two study arms including one-visit RCT (reference treatment; n = 202) and VPT/CEM (alternative treatment; n = 205). Six- and twelve-month clinical and radiographic successes were assessed.

Results

Mean follow-up times at 6- and 12-month follow-ups were “6.70 ± 0.68 and 6.72 ± 0.71 months” and “12.96 ± 0.67 and 12.90 ± 0.66 months” in the available cases of RCT and VPT/CEM arms, respectively. Favorable clinical success rates in the two study arms did not show statistical difference; however, the radiographic success rate in the VPT/CEM was significantly greater than RCT arm at the two follow-ups (P < 0.001). The patients’ age had no effect on the treatment outcomes (P = 0.231).

Conclusions

Treatment outcomes of VPT/CEM may be superior to RCT in mature molars with irreversible pulpitis. The performance of biomaterials such CEM cement may assist in the shift towards more biologic treatments.

Clinical relevance

VPT/CEM may be a realistic alternative treatment for human mature molar teeth with symptoms of irreversible pulpitis; the use of VPT/CEM is highly beneficial for patients as well as general dentists.
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Literatur
1.
Zurück zum Zitat Kojima K, Inamoto K, Nagamatsu K, Hara A, Nakata K, Morita I, Nakagaki H, Nakamura H (2004) Success rate of endodontic treatment of teeth with vital and nonvital pulps. A meta-analysis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97:95–99PubMedCrossRef Kojima K, Inamoto K, Nagamatsu K, Hara A, Nakata K, Morita I, Nakagaki H, Nakamura H (2004) Success rate of endodontic treatment of teeth with vital and nonvital pulps. A meta-analysis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97:95–99PubMedCrossRef
2.
Zurück zum Zitat Siqueira JF, Rôças IN, Riche FNSJ, Provenzano JC (2008) Clinical outcome of the endodontic treatment of teeth with apical periodontitis using an antimicrobial protocol. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106:757–762PubMedCrossRef Siqueira JF, Rôças IN, Riche FNSJ, Provenzano JC (2008) Clinical outcome of the endodontic treatment of teeth with apical periodontitis using an antimicrobial protocol. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106:757–762PubMedCrossRef
3.
Zurück zum Zitat Asgary S, Shadman B, Ghalamkarpour Z, Shahravan A, Ghoddusi J, Bagherpour A, Akbarzadeh Baghban A, Hashemipour M, Ghasemian Pour M (2010) Periapical status and quality of root canal fillings and coronal restorations in Iranian population. Iranian Endodontic J 5:74–82 Asgary S, Shadman B, Ghalamkarpour Z, Shahravan A, Ghoddusi J, Bagherpour A, Akbarzadeh Baghban A, Hashemipour M, Ghasemian Pour M (2010) Periapical status and quality of root canal fillings and coronal restorations in Iranian population. Iranian Endodontic J 5:74–82
4.
Zurück zum Zitat Goldberg M, Schmalz G (2011) Toward a strategic plan for pulp healing: from repair to regeneration. Clin Oral Investig 1–2 Goldberg M, Schmalz G (2011) Toward a strategic plan for pulp healing: from repair to regeneration. Clin Oral Investig 1–2
5.
Zurück zum Zitat Caplan DJ, Cai J, Yin G, White BA (2005) Root canal filled versus non-root canal filled teeth: a retrospective comparison of survival times. J Public Health Dent 65:90–96PubMedCrossRef Caplan DJ, Cai J, Yin G, White BA (2005) Root canal filled versus non-root canal filled teeth: a retrospective comparison of survival times. J Public Health Dent 65:90–96PubMedCrossRef
6.
Zurück zum Zitat McDougal RA, Delano EO, Caplan D, Sigurdsson A, Trope M (2004) Success of an alternative for interim management of irreversible pulpitis. J Am Dent Assoc 135:1707–1712PubMed McDougal RA, Delano EO, Caplan D, Sigurdsson A, Trope M (2004) Success of an alternative for interim management of irreversible pulpitis. J Am Dent Assoc 135:1707–1712PubMed
7.
Zurück zum Zitat Eghbal MJ, Asgary S, Baglue RA, Parirokh M, Ghoddusi J (2009) MTA pulpotomy of human permanent molars with irreversible pulpitis. Aust Endod J 35:4–8PubMedCrossRef Eghbal MJ, Asgary S, Baglue RA, Parirokh M, Ghoddusi J (2009) MTA pulpotomy of human permanent molars with irreversible pulpitis. Aust Endod J 35:4–8PubMedCrossRef
8.
Zurück zum Zitat Asgary S, Ehsani S (2009) Permanent molar pulpotomy with a new endodontic cement: a case series. J Conserv Dent 12:31–36PubMedCrossRef Asgary S, Ehsani S (2009) Permanent molar pulpotomy with a new endodontic cement: a case series. J Conserv Dent 12:31–36PubMedCrossRef
9.
Zurück zum Zitat Nosrat A, Asgary S (2010) Apexogenesis of a symptomatic molar with calcium enriched mixture. Int Endod J 43:940–944PubMedCrossRef Nosrat A, Asgary S (2010) Apexogenesis of a symptomatic molar with calcium enriched mixture. Int Endod J 43:940–944PubMedCrossRef
10.
Zurück zum Zitat Asgary S (2011) Calcium-enriched mixture pulpotomy of a human permanent molar with irreversible pulpitis and condensing apical periodontitis. J Conserv Dent 14:90–93PubMedCrossRef Asgary S (2011) Calcium-enriched mixture pulpotomy of a human permanent molar with irreversible pulpitis and condensing apical periodontitis. J Conserv Dent 14:90–93PubMedCrossRef
11.
Zurück zum Zitat Asgary S. Endodontic filling material, USA. 7,942,961, 2011 May 17 Asgary S. Endodontic filling material, USA. 7,942,961, 2011 May 17
12.
Zurück zum Zitat Asgary S, Eghbal MJ, Parirokh M (2008) Sealing ability of a novel endodontic cement as a root-end filling material. J Biomed Mater Res A 87:706–709PubMed Asgary S, Eghbal MJ, Parirokh M (2008) Sealing ability of a novel endodontic cement as a root-end filling material. J Biomed Mater Res A 87:706–709PubMed
13.
Zurück zum Zitat Asgary S, Kamrani FA (2008) Antibacterial effects of five different root canal sealing materials. J Oral Sci 50:469–474PubMedCrossRef Asgary S, Kamrani FA (2008) Antibacterial effects of five different root canal sealing materials. J Oral Sci 50:469–474PubMedCrossRef
14.
Zurück zum Zitat Asgary S, Shahabi S, Jafarzadeh T, Amini S, Kheirieh S (2008) The properties of a new endodontic material. J Endod 34:990–993PubMedCrossRef Asgary S, Shahabi S, Jafarzadeh T, Amini S, Kheirieh S (2008) The properties of a new endodontic material. J Endod 34:990–993PubMedCrossRef
15.
Zurück zum Zitat Asgary S, Eghbal MJ, Parirokh M, Ghoddusi J (2009) Effect of two storage solutions on surface topography of two root-end fillings. Aust Endod J 35:147–152PubMedCrossRef Asgary S, Eghbal MJ, Parirokh M, Ghoddusi J (2009) Effect of two storage solutions on surface topography of two root-end fillings. Aust Endod J 35:147–152PubMedCrossRef
16.
Zurück zum Zitat Asgary S, Eghbal MJ, Parirokh M, Ghoddusi J, Kheirieh S, Brink F (2009) Comparison of mineral trioxide aggregate’s composition with Portland cements and a new endodontic cement. J Endod 35:243–250PubMedCrossRef Asgary S, Eghbal MJ, Parirokh M, Ghoddusi J, Kheirieh S, Brink F (2009) Comparison of mineral trioxide aggregate’s composition with Portland cements and a new endodontic cement. J Endod 35:243–250PubMedCrossRef
17.
Zurück zum Zitat Asgary S, Eghbal MJ, Parirokh M, Ghanavati F, Rahimi H (2008) A comparative study of histologic response to different pulp capping materials and a novel endodontic cement. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106:609–614PubMedCrossRef Asgary S, Eghbal MJ, Parirokh M, Ghanavati F, Rahimi H (2008) A comparative study of histologic response to different pulp capping materials and a novel endodontic cement. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106:609–614PubMedCrossRef
18.
Zurück zum Zitat Parirokh M, Mirsoltani B, Raoof M, Tabrizchi H, Haghdoost AA (2011) Comparative study of subcutaneous tissue responses to a novel root-end filling material and white and grey mineral trioxide aggregate. Int Endod J 44:283–289PubMedCrossRef Parirokh M, Mirsoltani B, Raoof M, Tabrizchi H, Haghdoost AA (2011) Comparative study of subcutaneous tissue responses to a novel root-end filling material and white and grey mineral trioxide aggregate. Int Endod J 44:283–289PubMedCrossRef
19.
Zurück zum Zitat Asgary S, Eghbal MJ, Ehsani S (2010) Periradicular regeneration after endodontic surgery with calcium-enriched mixture cement in dogs. J Endod 36:837–841PubMedCrossRef Asgary S, Eghbal MJ, Ehsani S (2010) Periradicular regeneration after endodontic surgery with calcium-enriched mixture cement in dogs. J Endod 36:837–841PubMedCrossRef
20.
Zurück zum Zitat Samiee MEM, Parirokh M, Abbas FM, Asgary S (2009) Repair of furcal perforation using a new endodontic cement. Clin Oral Investig 14:653–658PubMedCrossRef Samiee MEM, Parirokh M, Abbas FM, Asgary S (2009) Repair of furcal perforation using a new endodontic cement. Clin Oral Investig 14:653–658PubMedCrossRef
21.
Zurück zum Zitat Tabarsi B, Parirokh M, Eghbal M, Haghdoost A, Torabzadeh H, Asgary S (2010) A comparative study of dental pulp response to different pulpotomy agents. Int Endod J 43:565–571 Tabarsi B, Parirokh M, Eghbal M, Haghdoost A, Torabzadeh H, Asgary S (2010) A comparative study of dental pulp response to different pulpotomy agents. Int Endod J 43:565–571
22.
Zurück zum Zitat Asgary S, Eghbal MJ (2010) The effect of pulpotomy using a calcium-enriched mixture cement versus one-visit root canal therapy on postoperative pain relief in irreversible pulpitis: a randomized clinical trial. Odontology 98:126–133PubMedCrossRef Asgary S, Eghbal MJ (2010) The effect of pulpotomy using a calcium-enriched mixture cement versus one-visit root canal therapy on postoperative pain relief in irreversible pulpitis: a randomized clinical trial. Odontology 98:126–133PubMedCrossRef
23.
Zurück zum Zitat LZ S (1965) The dependence of the results of pulp therapy on certain factors. Acta Odontol Scand 14 (suppl 21): LZ S (1965) The dependence of the results of pulp therapy on certain factors. Acta Odontol Scand 14 (suppl 21):
24.
Zurück zum Zitat Dugas NN, Lawrence HP, Teplitsky P, Friedman S (2002) Quality of life and satisfaction outcomes of endodontic treatment. J Endod 28:819–827PubMedCrossRef Dugas NN, Lawrence HP, Teplitsky P, Friedman S (2002) Quality of life and satisfaction outcomes of endodontic treatment. J Endod 28:819–827PubMedCrossRef
25.
Zurück zum Zitat Friedman S, Mor C (2004) The success of endodontic therapy—healing and functionality. J Calif Dent Assoc 32:493–503PubMed Friedman S, Mor C (2004) The success of endodontic therapy—healing and functionality. J Calif Dent Assoc 32:493–503PubMed
26.
Zurück zum Zitat Dugas NNLH, Teplitsky PE, Pharoah MJ, Friedman S (2003) Periapical health and treatment quality assessment of root-filled teeth in two Canadian populations. Int Endod J 36:181–192PubMedCrossRef Dugas NNLH, Teplitsky PE, Pharoah MJ, Friedman S (2003) Periapical health and treatment quality assessment of root-filled teeth in two Canadian populations. Int Endod J 36:181–192PubMedCrossRef
27.
Zurück zum Zitat Wang Z, Pan J, Wright JT, Bencharit S, Zhang S, Everett ET, Teixeira FB, Preisser JS (2010) Putative stem cells in human dental pulp with irreversible pulpitis: an exploratory study. J Endod 36:820–825PubMedCrossRef Wang Z, Pan J, Wright JT, Bencharit S, Zhang S, Everett ET, Teixeira FB, Preisser JS (2010) Putative stem cells in human dental pulp with irreversible pulpitis: an exploratory study. J Endod 36:820–825PubMedCrossRef
28.
Zurück zum Zitat Aguilar P, Linsuwanont P (2011) Vital pulp therapy in vital permanent teeth with cariously exposed pulp: a systematic review. J Endod 37:581–587PubMedCrossRef Aguilar P, Linsuwanont P (2011) Vital pulp therapy in vital permanent teeth with cariously exposed pulp: a systematic review. J Endod 37:581–587PubMedCrossRef
29.
Zurück zum Zitat Bogen G, Chandler N (2008) Vital pulp therapy. In: Ingle (ed) Ingle's endodontics, 6th edn. BC Decker INC, Lewiston, pp 1310–1329 Bogen G, Chandler N (2008) Vital pulp therapy. In: Ingle (ed) Ingle's endodontics, 6th edn. BC Decker INC, Lewiston, pp 1310–1329
30.
Zurück zum Zitat Bjorndal L (2008) Indirect pulp therapy and stepwise excavation. Pediatr Dent 30:225–229PubMed Bjorndal L (2008) Indirect pulp therapy and stepwise excavation. Pediatr Dent 30:225–229PubMed
31.
Zurück zum Zitat Levin LG, Law AS, Holland GR, Abbott PV, Roda RS (2009) Identify and define all diagnostic terms for pulpal health and disease states. J Endod 35:1645–1657PubMedCrossRef Levin LG, Law AS, Holland GR, Abbott PV, Roda RS (2009) Identify and define all diagnostic terms for pulpal health and disease states. J Endod 35:1645–1657PubMedCrossRef
32.
Zurück zum Zitat Seltzer S, Bender IB, Ziontz M (1963) The dynamics of pulp inflammation: correlations between diagnostic data and actual histologic findings in the pulp. Oral Surg Oral Med Oral Pathol 16:969–977PubMedCrossRef Seltzer S, Bender IB, Ziontz M (1963) The dynamics of pulp inflammation: correlations between diagnostic data and actual histologic findings in the pulp. Oral Surg Oral Med Oral Pathol 16:969–977PubMedCrossRef
33.
Zurück zum Zitat Matsuo T, Nakanishi T, Shimizu H, Ebisu S (1996) A clinical study of direct pulp capping applied to carious-exposed pulps. J Endod 22:551–556PubMedCrossRef Matsuo T, Nakanishi T, Shimizu H, Ebisu S (1996) A clinical study of direct pulp capping applied to carious-exposed pulps. J Endod 22:551–556PubMedCrossRef
34.
Zurück zum Zitat Caliskan MK (1995) Pulpotomy of carious vital teeth with periapical involvement. Int Endod J 28:172–176PubMedCrossRef Caliskan MK (1995) Pulpotomy of carious vital teeth with periapical involvement. Int Endod J 28:172–176PubMedCrossRef
35.
Zurück zum Zitat Piaggio G, Elbourne DR, Altman DG, Pocock SJ, Evans SJ (2006) Reporting of noninferiority and equivalence randomized trials: an extension of the CONSORT statement. JAMA 295:1152–1160PubMedCrossRef Piaggio G, Elbourne DR, Altman DG, Pocock SJ, Evans SJ (2006) Reporting of noninferiority and equivalence randomized trials: an extension of the CONSORT statement. JAMA 295:1152–1160PubMedCrossRef
36.
Zurück zum Zitat Bohay RN (2000) The sensitivity, specificity, and reliability of radiographic periapical diagnosis of posterior teeth. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 89:639–642PubMedCrossRef Bohay RN (2000) The sensitivity, specificity, and reliability of radiographic periapical diagnosis of posterior teeth. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 89:639–642PubMedCrossRef
37.
Zurück zum Zitat Landis JR, Koch GG (1977) The measurement of observer agreement for categorical data. Biometrics 33:159–174PubMedCrossRef Landis JR, Koch GG (1977) The measurement of observer agreement for categorical data. Biometrics 33:159–174PubMedCrossRef
38.
Zurück zum Zitat Dammaschke T, Leidinger J, Schafer E (2010) Long-term evaluation of direct pulp capping—treatment outcomes over an average period of 6.1 years. Clin Oral Investig 14:559–567PubMedCrossRef Dammaschke T, Leidinger J, Schafer E (2010) Long-term evaluation of direct pulp capping—treatment outcomes over an average period of 6.1 years. Clin Oral Investig 14:559–567PubMedCrossRef
39.
Zurück zum Zitat Orstavik D (1996) Time-course and risk analyses of the development and healing of chronic apical periodontitis in man. Int Endod J 29:150–155PubMedCrossRef Orstavik D (1996) Time-course and risk analyses of the development and healing of chronic apical periodontitis in man. Int Endod J 29:150–155PubMedCrossRef
40.
Zurück zum Zitat Fristad I, Molven O, Halse A (2004) Nonsurgically retreated root filled teeth—radiographic findings after 20–27 years. Int Endod J 37:12–18PubMedCrossRef Fristad I, Molven O, Halse A (2004) Nonsurgically retreated root filled teeth—radiographic findings after 20–27 years. Int Endod J 37:12–18PubMedCrossRef
41.
Zurück zum Zitat Salehrabi R, Rotstein I (2004) Endodontic treatment outcomes in a large patient population in the USA: an epidemiological study. J Endod 30:846–850PubMedCrossRef Salehrabi R, Rotstein I (2004) Endodontic treatment outcomes in a large patient population in the USA: an epidemiological study. J Endod 30:846–850PubMedCrossRef
42.
Zurück zum Zitat Bjørndal L, Laustsen M, Reit C (2006) Root canal treatment in Denmark is most often carried out in carious vital molar teeth and retreatments are rare. Int Endod J 39:785–790PubMedCrossRef Bjørndal L, Laustsen M, Reit C (2006) Root canal treatment in Denmark is most often carried out in carious vital molar teeth and retreatments are rare. Int Endod J 39:785–790PubMedCrossRef
43.
Zurück zum Zitat Asgary S, Eghbal M (2012) Treatment outcomes of pulpotomy in permanent molars with irreversible pulpitis using biomaterials: a multicenter randomized controlled trial. Acta Odontol Scand. doi:10.3109/00016357.2011.654251 Asgary S, Eghbal M (2012) Treatment outcomes of pulpotomy in permanent molars with irreversible pulpitis using biomaterials: a multicenter randomized controlled trial. Acta Odontol Scand. doi:10.​3109/​00016357.​2011.​654251
44.
Zurück zum Zitat Alongi DJ, Yamaza T, Song Y, Fouad AF, Romberg EE, Shi S, Tuan RS, Huang GT (2010) Stem/progenitor cells from inflamed human dental pulp retain tissue regeneration potential. Regen Med 5:617–631PubMedCrossRef Alongi DJ, Yamaza T, Song Y, Fouad AF, Romberg EE, Shi S, Tuan RS, Huang GT (2010) Stem/progenitor cells from inflamed human dental pulp retain tissue regeneration potential. Regen Med 5:617–631PubMedCrossRef
45.
Zurück zum Zitat Ranly DM, Garcia-Godoy F (2000) Current and potential pulp therapies for primary and young permanent teeth. J Dent 28:153–161PubMedCrossRef Ranly DM, Garcia-Godoy F (2000) Current and potential pulp therapies for primary and young permanent teeth. J Dent 28:153–161PubMedCrossRef
46.
Zurück zum Zitat Massler M (1978) Preserving the exposed pulp: a review. J Pedod 2:217–227PubMed Massler M (1978) Preserving the exposed pulp: a review. J Pedod 2:217–227PubMed
47.
Zurück zum Zitat Nosrat A, Seifi A, Asgary S (2011) Regenerative endodontic treatment (revascularization) for necrotic immature permanent molars: a review and report of two cases with a new biomaterial. J Endod 37:562–567PubMedCrossRef Nosrat A, Seifi A, Asgary S (2011) Regenerative endodontic treatment (revascularization) for necrotic immature permanent molars: a review and report of two cases with a new biomaterial. J Endod 37:562–567PubMedCrossRef
48.
Zurück zum Zitat Malekafzali B, Shekarchi F, Asgary S (2011) Treatment outcomes of pulpotomy in primary molars using two endodontic biomaterials. A 2-year randomised clinical trial. Eur J Paediatr Dent 12:189–193PubMed Malekafzali B, Shekarchi F, Asgary S (2011) Treatment outcomes of pulpotomy in primary molars using two endodontic biomaterials. A 2-year randomised clinical trial. Eur J Paediatr Dent 12:189–193PubMed
49.
Zurück zum Zitat Nosrat A, Seifi A, Asgary S (2012) Pulpotomy in caries-exposed immature permanent molars using calcium-enriched mixture cement or mineral trioxide aggregate: a randomized clinical trial. Int J Paediatr Dent. doi:10.1111/j.1365-263X.2012.01224.x Nosrat A, Seifi A, Asgary S (2012) Pulpotomy in caries-exposed immature permanent molars using calcium-enriched mixture cement or mineral trioxide aggregate: a randomized clinical trial. Int J Paediatr Dent. doi:10.​1111/​j.​1365-263X.​2012.​01224.​x
50.
Zurück zum Zitat Asgary S (2010) Furcal perforation repair using calcium enriched mixture cement. J Conserv Dent 13:156–158PubMedCrossRef Asgary S (2010) Furcal perforation repair using calcium enriched mixture cement. J Conserv Dent 13:156–158PubMedCrossRef
51.
Zurück zum Zitat Zarrabi MH, Javidi M, Jafarian AH, Joushan B (2010) Histologic assessment of human pulp response to capping with mineral trioxide aggregate and a novel endodontic cement. J Endod 36:1778–1781PubMedCrossRef Zarrabi MH, Javidi M, Jafarian AH, Joushan B (2010) Histologic assessment of human pulp response to capping with mineral trioxide aggregate and a novel endodontic cement. J Endod 36:1778–1781PubMedCrossRef
52.
Zurück zum Zitat Nosrat A, Asgary S (2010) Apexogenesis treatment with a new endodontic cement: a case report. J Endod 36:912–914PubMedCrossRef Nosrat A, Asgary S (2010) Apexogenesis treatment with a new endodontic cement: a case report. J Endod 36:912–914PubMedCrossRef
53.
Zurück zum Zitat Asgary SNA, Seifi A (2011) Management of inflammatory external root resorption using calcium-enriched mixture cement. J Endod 37:411–413PubMedCrossRef Asgary SNA, Seifi A (2011) Management of inflammatory external root resorption using calcium-enriched mixture cement. J Endod 37:411–413PubMedCrossRef
54.
Zurück zum Zitat Hasan Zarrabi M, Javidi M, Naderinasab M, Gharechahi M (2009) Comparative evaluation of antimicrobial activity of three cements: new endodontic cement (NEC), mineral trioxide aggregate (MTA) and Portland. J Oral Sci 51:437–442PubMedCrossRef Hasan Zarrabi M, Javidi M, Naderinasab M, Gharechahi M (2009) Comparative evaluation of antimicrobial activity of three cements: new endodontic cement (NEC), mineral trioxide aggregate (MTA) and Portland. J Oral Sci 51:437–442PubMedCrossRef
55.
Zurück zum Zitat Ward J (2002) Vital pulp therapy in cariously exposed permanent teeth and its limitations. Aust Endod J 28:29–37PubMedCrossRef Ward J (2002) Vital pulp therapy in cariously exposed permanent teeth and its limitations. Aust Endod J 28:29–37PubMedCrossRef
56.
Zurück zum Zitat Mente J, Geletneky B, Ohle M, Koch MJ, Friedrich Ding PG, Wolff D, Dreyhaupt J, Martin N, Staehle HJ, Pfefferle T (2010) Mineral trioxide aggregate or calcium hydroxide direct pulp capping: an analysis of the clinical treatment outcome. J Endod 36:806–813PubMedCrossRef Mente J, Geletneky B, Ohle M, Koch MJ, Friedrich Ding PG, Wolff D, Dreyhaupt J, Martin N, Staehle HJ, Pfefferle T (2010) Mineral trioxide aggregate or calcium hydroxide direct pulp capping: an analysis of the clinical treatment outcome. J Endod 36:806–813PubMedCrossRef
57.
58.
Zurück zum Zitat Schmalz G (2009) Determination of biocompatibility. In: Schmalz G, Arenholt-Bindslev D (eds) Biocompatibility of dental materials. Springer, Verlag Berlin Heidelberg, pp 13–44CrossRef Schmalz G (2009) Determination of biocompatibility. In: Schmalz G, Arenholt-Bindslev D (eds) Biocompatibility of dental materials. Springer, Verlag Berlin Heidelberg, pp 13–44CrossRef
Metadaten
Titel
One-year results of vital pulp therapy in permanent molars with irreversible pulpitis: an ongoing multicenter, randomized, non-inferiority clinical trial
verfasst von
Saeed Asgary
Mohammad Jafar Eghbal
Jamileh Ghoddusi
Shahram Yazdani
Publikationsdatum
01.03.2013
Verlag
Springer-Verlag
Erschienen in
Clinical Oral Investigations / Ausgabe 2/2013
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-012-0712-6

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