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Clinical Oral Investigations
Erschienen in: Clinical Oral Investigations 6/2013

01.07.2013 | Original Article

Pulpal and periodontal diseases increase triglyceride levels in diabetic rats

verfasst von: Luciano Tavares Angelo Cintra, Aguinaldo Cândido da Silva Facundo, Mariane Maffei Azuma, Dóris Hissako Sumida, Rafael Dias Astolphi, Suely Regina Mogami Bomfim, Luís Gustavo Narciso, João Eduardo Gomes-Filho

Erschienen in: Clinical Oral Investigations | Ausgabe 6/2013

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Abstract

Objectives

The aim of this study was to evaluate triglyceride and cholesterol levels in diabetic rats and their relationship with pulpal and periodontal diseases.

Methods

Eighty male rats (Rattus norvegicus albinus, Wistar) were divided into the following eight groups comprising ten animals each: normal rats (G1), rats with pulpal diseases (G2), rats with periodontal diseases (G3), rats with both pulpal and periodontal diseases (G4), diabetic rats (G5), diabetic rats with pulpal diseases (G6), diabetic rats with periodontal diseases (G7), and diabetic rats with both periodontal and pulpal diseases (G8). Diabetes was induced by injecting streptozotocin, periapical lesions were induced by exposing pulpal tissue to the oral environment, and periodontal diseases were induced by periodontal ligature. The animals were killed after 30 days, and lipid profile was enzymatically measured using Trinder’s method. The total assessed values were statistically analyzed by analysis of variance and Tukey test (p < 0.05).

Results

The triglyceride levels of diabetic rats with periodontal disease and of diabetic rats with both periodontal and pulpal diseases were significantly higher than those of normal rats and nondiabetic group rats, respectively. The differences in the cholesterol levels among the groups were not significant.

Conclusions

We found that the association of pulpal and periodontal diseases with diabetes increased triglyceride levels in rats.

Clinical significance

Changes in lipid profile may be related to the presence of oral infections and diabetes.
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Metadaten
Titel
Pulpal and periodontal diseases increase triglyceride levels in diabetic rats
verfasst von
Luciano Tavares Angelo Cintra
Aguinaldo Cândido da Silva Facundo
Mariane Maffei Azuma
Dóris Hissako Sumida
Rafael Dias Astolphi
Suely Regina Mogami Bomfim
Luís Gustavo Narciso
João Eduardo Gomes-Filho
Publikationsdatum
01.07.2013
Verlag
Springer-Verlag
Erschienen in
Clinical Oral Investigations / Ausgabe 6/2013
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-012-0853-7

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