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01.11.2015 | Original Article

Nano/micro fluorhydroxyapatite crystal pastes in the treatment of dentin hypersensitivity: an in vitro study

verfasst von: Sahar T. Taha, Hua Han, Sywe-Ren Chang, Iva Sovadinova, Kenichi Kuroda, Richard M. Langford, Brian H. Clarkson

Erschienen in: Clinical Oral Investigations | Ausgabe 8/2015

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Abstract

Objectives

Dentin hypersensitivity (DH) is a prevalent problem. This study aimed to formulate a paste using fluorhydroxyapatite (FA) crystals dispersed in different carriers to treat DH. The ability to occlude patent dentinal tubules and to release ions was investigated.

Materials and methods

Twenty percent FA/sodium alginate, 40 % FA/poly(hydroxyethyl methacylate(HEMA)), and 40 % FA/poly(DMA-co-MEA) were applied to etched dentin samples and examined with scanning electron microscopy (SEM) to determine the degree of tubule occlusion. Fluoride electrode was used to measure F release and spectroscopy to evaluate Ca and PO₄ release. The cytotoxicity of the synthesized poly(DMA-co-MEA) gel was tested. Kruskall-Wallis test was used to test the differences in ion release between the groups.

Results

FA/poly(DMA-co-MEA) paste obstructed up to 80 % of the dentinal tubules, while the coverage was up to 70 % for FA/poly(HEMA) and less than 50 % for FA/sodium alginate. Fluoride and Ca release was the highest for FA/P(HEMA), 7.2 ± 0.7 and 139.8 ± 32.5 ppm, respectively. The highest concentration of PO₄ was 46.2 ± 16.4 ppm for FA/Sodium alginate. No statistical significance was found.

Conclusions

FA/Poly(DMA-co-MEA) and FA/poly(HEMA) pastes may offer immediate short-term relief of DH because of their ability to occlude the tubules and adhere to wet dentin surfaces. The release of the F, Ca, and PO₄ ions may offer long-term relief by forming a mineral barrier both within the dentinal tubules and on the dentin surface.

Clinical significance

The tested materials may offer a long-term treatment for DH.

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Titel: Nano/micro fluorhydroxyapatite crystal pastes in the treatment of dentin hypersensitivity: an in vitro study
verfasst von: Sahar T. Taha
Hua Han
Sywe-Ren Chang
Iva Sovadinova
Kenichi Kuroda
Richard M. Langford
Brian H. Clarkson
Publikationsdatum: 01.11.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Oral Investigations / Ausgabe 8/2015
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-015-1427-2

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Nano/micro fluorhydroxyapatite crystal pastes in the treatment of dentin hypersensitivity: an in vitro study

Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical significance

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Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical significance

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