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European Child & Adolescent Psychiatry

Erschienen in:

01.03.2010 | Review

Phenotypic and measurement influences on heritability estimates in childhood ADHD

verfasst von: Christine M. Freitag, Luis A. Rohde, Thomas Lempp, Marcel Romanos

Erschienen in: European Child & Adolescent Psychiatry | Ausgabe 3/2010

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Abstract

Twin studies described a strongly heritable component of attention-deficit/hyperactivity disorder (ADHD) in children and adolescents. However, findings varied considerably between studies. In addition, ADHD presents with a high rate of comorbid disorders and associated psychopathology. Therefore, this literature review reports findings from population-based twin studies regarding the influence of subtypes, assessment instruments, rater effects, sex differences, and comorbidity rates on ADHD heritability estimates. In addition, genetic effects on the persistence of ADHD are discussed. By reviewing relevant factors influencing heritability estimates more homogeneous subtypes relevant for molecular genetic studies can be elicited. A systematic search of population-based twin studies in ADHD was performed, using the databases PubMed and PsycInfo. Results of family studies were added in case insufficient or contradictory findings were obtained in twin studies. Heritability estimates were strongly influenced by rater effects and assessment instruments. Inattentive and hyperactive–impulsive symptoms were likely influenced by common as well as specific genetic risk factors. Besides persistent ADHD, ADHD accompanied by symptoms of conduct or antisocial personality disorder might be another strongly genetically determined subtype, however, family environmental risk factors have also been established for this pattern of comorbidity.

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Titel: Phenotypic and measurement influences on heritability estimates in childhood ADHD
verfasst von: Christine M. Freitag
Luis A. Rohde
Thomas Lempp
Marcel Romanos
Publikationsdatum: 01.03.2010
Verlag: Springer-Verlag
Erschienen in: European Child & Adolescent Psychiatry / Ausgabe 3/2010
Print ISSN: 1018-8827
Elektronische ISSN: 1435-165X
DOI: https://doi.org/10.1007/s00787-010-0097-5

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Phenotypic and measurement influences on heritability estimates in childhood ADHD

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