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01.03.2014 | Original Contribution

Serum brain-derived neurotrophic factor (BDNF) levels in attention deficit–hyperactivity disorder (ADHD)

verfasst von: Catia Scassellati, Roberta Zanardini, Alessandra Tiberti, Marco Pezzani, Vera Valenti, Paola Effedri, Elena Filippini, Stefano Conte, Alberto Ottolini, Massimo Gennarelli, Luisella Bocchio-Chiavetto

Erschienen in: European Child & Adolescent Psychiatry | Ausgabe 3/2014

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Abstract

It has been proposed that the neurotrophin brain-derived neurotrophic factor (BDNF) may be involved in attention deficit–hyperactivity disorder (ADHD) etiopathogenesis. Alterations in BDNF serum levels have been observed in childhood/adulthood neurodevelopmental pathologies, but no evidence is available for BDNF serum concentrations in ADHD. The study includes 45 drug-naïve ADHD children and 45 age–sex matched healthy subjects. Concentration of serum BDNF was determined by the ELISA method. BDNF serum levels in patients with ADHD were not different from those of controls (mean ± SD; ADHD: 39.33 ± 10.41 ng/ml; controls: 38.82 ± 8.29 ng/ml, t = −0.26, p = 0.80). Our findings indicate no alteration of serum BDNF levels in untreated patients with ADHD. A further stratification for cognitive, neuropsychological and psychopathological assessment in a larger sample could be useful to clarify the role of BDNF in the endophenotype characterization of ADHD.

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Titel: Serum brain-derived neurotrophic factor (BDNF) levels in attention deficit–hyperactivity disorder (ADHD)
verfasst von: Catia Scassellati
Roberta Zanardini
Alessandra Tiberti
Marco Pezzani
Vera Valenti
Paola Effedri
Elena Filippini
Stefano Conte
Alberto Ottolini
Massimo Gennarelli
Luisella Bocchio-Chiavetto
Publikationsdatum: 01.03.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: European Child & Adolescent Psychiatry / Ausgabe 3/2014
Print ISSN: 1018-8827
Elektronische ISSN: 1435-165X
DOI: https://doi.org/10.1007/s00787-013-0447-1

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