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Erschienen in: European Child & Adolescent Psychiatry 3/2015

01.03.2015 | Original Contribution

The NeuroIMAGE study: a prospective phenotypic, cognitive, genetic and MRI study in children with attention-deficit/hyperactivity disorder. Design and descriptives

verfasst von: Daniel von Rhein, Maarten Mennes, Hanneke van Ewijk, Annabeth P. Groenman, Marcel P. Zwiers, Jaap Oosterlaan, Dirk Heslenfeld, Barbara Franke, Pieter J. Hoekstra, Stephen V. Faraone, Catharina Hartman, Jan Buitelaar

Erschienen in: European Child & Adolescent Psychiatry | Ausgabe 3/2015

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Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a persistent neuropsychiatric disorder which is associated with impairments on a variety of cognitive measures and abnormalities in structural and functional brain measures. Genetic factors are thought to play an important role in the etiology of ADHD. The NeuroIMAGE study is a follow-up of the Dutch part of the International Multicenter ADHD Genetics (IMAGE) project. It is a multi-site prospective cohort study designed to investigate the course of ADHD, its genetic and environmental determinants, its cognitive and neurobiological underpinnings, and its consequences in adolescence and adulthood. From the original 365 ADHD families and 148 control (CON) IMAGE families, consisting of 506 participants with an ADHD diagnosis, 350 unaffected siblings, and 283 healthy controls, 79 % participated in the NeuroIMAGE follow-up study. Combined with newly recruited participants the NeuroIMAGE study comprehends an assessment of 1,069 children (751 from ADHD families; 318 from CON families) and 848 parents (582 from ADHD families; 266 from CON families). For most families, data for more than one child (82 %) and both parents (82 %) were available. Collected data include a diagnostic interview, behavioural questionnaires, cognitive measures, structural and functional neuroimaging, and genome-wide genetic information. The NeuroIMAGE dataset allows examining the course of ADHD over adolescence into young adulthood, identifying phenotypic, cognitive, and neural mechanisms associated with the persistence versus remission of ADHD, and studying their genetic and environmental underpinnings. The inclusion of siblings of ADHD probands and controls allows modelling of shared familial influences on the ADHD phenotype.
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Literatur
9.
Zurück zum Zitat Willcutt E, Sonuga-Barke E, Nigg J, Sergeant J (2008) Recent developments in neuropsychological models of childhood psychiatric disorders. In: Banaschewski T, Rohde LA (eds) Biological child psychiatry. Recent trends and developments, vol 24. Karger Publishers, Basel, pp 195–226. doi:10.1016/j.chc.2007.11.008 Willcutt E, Sonuga-Barke E, Nigg J, Sergeant J (2008) Recent developments in neuropsychological models of childhood psychiatric disorders. In: Banaschewski T, Rohde LA (eds) Biological child psychiatry. Recent trends and developments, vol 24. Karger Publishers, Basel, pp 195–226. doi:10.​1016/​j.​chc.​2007.​11.​008
20.
21.
Zurück zum Zitat Scheres A, Oosterlaan J, Sergeant JA (2001) Response execution and inhibition in children with AD/HD and other disruptive disorders: the role of behavioural activation. J Child Psychol Psychiatry 42:347–357CrossRefPubMed Scheres A, Oosterlaan J, Sergeant JA (2001) Response execution and inhibition in children with AD/HD and other disruptive disorders: the role of behavioural activation. J Child Psychol Psychiatry 42:347–357CrossRefPubMed
22.
Zurück zum Zitat Brookes K, Xu X, Chen W et al (2006) The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes. Mol Psychiatry 11:934–953. doi:10.1038/sj.mp.4001869 CrossRefPubMed Brookes K, Xu X, Chen W et al (2006) The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes. Mol Psychiatry 11:934–953. doi:10.​1038/​sj.​mp.​4001869 CrossRefPubMed
25.
Zurück zum Zitat Asherson P, Zhou K, Anney RJL et al (2008) A high-density SNP linkage scan with 142 combined subtype ADHD sib pairs identifies linkage regions on chromosomes 9 and 16. Mol Psychiatry 13:514–521. doi:10.1038/sj.mp.4002140 CrossRefPubMed Asherson P, Zhou K, Anney RJL et al (2008) A high-density SNP linkage scan with 142 combined subtype ADHD sib pairs identifies linkage regions on chromosomes 9 and 16. Mol Psychiatry 13:514–521. doi:10.​1038/​sj.​mp.​4002140 CrossRefPubMed
28.
Zurück zum Zitat Lasky-Su J, Neale BM, Franke B et al (2008) Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. Am J Med Genet B Neuropsychiatr Genet 147B:1345–1354. doi:10.1002/ajmg.b.30867 CrossRefPubMed Lasky-Su J, Neale BM, Franke B et al (2008) Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. Am J Med Genet B Neuropsychiatr Genet 147B:1345–1354. doi:10.​1002/​ajmg.​b.​30867 CrossRefPubMed
36.
Zurück zum Zitat Gottesman II, Gould TD (2003) The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 160:636–645CrossRefPubMed Gottesman II, Gould TD (2003) The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 160:636–645CrossRefPubMed
37.
Zurück zum Zitat Rommelse NNJ, Geurts HM, Franke B et al (2011) A review on cognitive and brain endophenotypes that may be common in autism spectrum disorder and attention-deficit/hyperactivity disorder and facilitate the search for pleiotropic genes. Neurosci Biobehav Rev 35:1363–1396. doi:10.1016/j.neubiorev.2011.02.015 CrossRefPubMed Rommelse NNJ, Geurts HM, Franke B et al (2011) A review on cognitive and brain endophenotypes that may be common in autism spectrum disorder and attention-deficit/hyperactivity disorder and facilitate the search for pleiotropic genes. Neurosci Biobehav Rev 35:1363–1396. doi:10.​1016/​j.​neubiorev.​2011.​02.​015 CrossRefPubMed
38.
Zurück zum Zitat Groenman AP, Oosterlaan J, Rommelse N et al (2013) Substance use disorders in adolescents with attention deficit hyperactivity disorder: a 4-year follow-up study. Addiction 108:1503–1511. doi:10.1111/add.12188 CrossRefPubMed Groenman AP, Oosterlaan J, Rommelse N et al (2013) Substance use disorders in adolescents with attention deficit hyperactivity disorder: a 4-year follow-up study. Addiction 108:1503–1511. doi:10.​1111/​add.​12188 CrossRefPubMed
43.
Zurück zum Zitat van Lieshout M, Luman M, Twisk JWR et al. Persistence rates and symptom change in attention-deficit/hyperactivity disorder (submitted) van Lieshout M, Luman M, Twisk JWR et al. Persistence rates and symptom change in attention-deficit/hyperactivity disorder (submitted)
44.
Zurück zum Zitat Conners CK, Erhardt D, Sparrow E (1999) Conners’ adult ADHD rating scales: technical manual. Multi-Health Systems, New York Conners CK, Erhardt D, Sparrow E (1999) Conners’ adult ADHD rating scales: technical manual. Multi-Health Systems, New York
45.
Zurück zum Zitat Conners CK, Sitarenios G, Parker JD, Epstein JN (1998) The revised Conners’ Parent Rating Scale (CPRS-R): factor structure, reliability, and criterion validity. J Abnorm Child Psychol 26:257–268CrossRefPubMed Conners CK, Sitarenios G, Parker JD, Epstein JN (1998) The revised Conners’ Parent Rating Scale (CPRS-R): factor structure, reliability, and criterion validity. J Abnorm Child Psychol 26:257–268CrossRefPubMed
46.
Zurück zum Zitat Conners CK, Wells KC, Parker JDA et al (1997) A new self-report scale for assessment of adolescent psychopathology: factor structure, reliability, validity, and diagnostic sensitivity. J Abnorm Child Psychol 25:487–497. doi:10.1023/A:1022637815797 CrossRefPubMed Conners CK, Wells KC, Parker JDA et al (1997) A new self-report scale for assessment of adolescent psychopathology: factor structure, reliability, validity, and diagnostic sensitivity. J Abnorm Child Psychol 25:487–497. doi:10.​1023/​A:​1022637815797 CrossRefPubMed
50.
Zurück zum Zitat Sobell LC, Brown J, Leo GI, Sobell MB (1996) The reliability of the Alcohol Timeline Followback when administered by telephone and by computer. Drug Alcohol Depend 42:49–54CrossRefPubMed Sobell LC, Brown J, Leo GI, Sobell MB (1996) The reliability of the Alcohol Timeline Followback when administered by telephone and by computer. Drug Alcohol Depend 42:49–54CrossRefPubMed
51.
Zurück zum Zitat Selzer ML, Vinokur A, van Rooijen L (1975) A self-administered Short Michigan Alcoholism Screening Test (SMAST). J Stud Alcohol 36:117–126PubMed Selzer ML, Vinokur A, van Rooijen L (1975) A self-administered Short Michigan Alcoholism Screening Test (SMAST). J Stud Alcohol 36:117–126PubMed
52.
Zurück zum Zitat Lesieur HR, Blume SB (1987) The South Oaks Gambling Screen (SOGS): a new instrument for the identification of pathological gamblers. Am J Psychiatry 144(9):1184–1188 Lesieur HR, Blume SB (1987) The South Oaks Gambling Screen (SOGS): a new instrument for the identification of pathological gamblers. Am J Psychiatry 144(9):1184–1188
54.
Zurück zum Zitat Shaffer D, Fisher P, Lucas CP et al (2000) NIMH Diagnostic Interview Schedule for Children Version IV (NIMH DISC-IV): description, differences from previous versions, and reliability of some common diagnoses. J Am Acad Child Adolesc Psychiatry 39:28–38. doi:10.1097/00004583-200001000-00014 CrossRefPubMed Shaffer D, Fisher P, Lucas CP et al (2000) NIMH Diagnostic Interview Schedule for Children Version IV (NIMH DISC-IV): description, differences from previous versions, and reliability of some common diagnoses. J Am Acad Child Adolesc Psychiatry 39:28–38. doi:10.​1097/​00004583-200001000-00014 CrossRefPubMed
55.
Zurück zum Zitat Johnston L, O’Malley PM, Bachman JG (1998) National survey results on drug use from the Monitoring the Future Study, 1975–1997 Johnston L, O’Malley PM, Bachman JG (1998) National survey results on drug use from the Monitoring the Future Study, 1975–1997
57.
Zurück zum Zitat Kaufman J, Birmaher B, Brent D et al (1997) Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 36:980–988. doi:10.1097/00004583-199707000-00021 CrossRefPubMed Kaufman J, Birmaher B, Brent D et al (1997) Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 36:980–988. doi:10.​1097/​00004583-199707000-00021 CrossRefPubMed
60.
Zurück zum Zitat Kessler RC, Andrews G, Colpe LJ et al (2002) Short screening scales to monitor population prevalences and trends in non-specific psychological distress. Psychol Med 32:959–976CrossRefPubMed Kessler RC, Andrews G, Colpe LJ et al (2002) Short screening scales to monitor population prevalences and trends in non-specific psychological distress. Psychol Med 32:959–976CrossRefPubMed
61.
Zurück zum Zitat Conners CK, Sitarenios G, Parker JD, Epstein JN (1998) Revision and restandardization of the Conners Teacher Rating Scale (CTRS-R): factor structure, reliability, and criterion validity. J Abnorm Child Psychol 26:279–291CrossRefPubMed Conners CK, Sitarenios G, Parker JD, Epstein JN (1998) Revision and restandardization of the Conners Teacher Rating Scale (CTRS-R): factor structure, reliability, and criterion validity. J Abnorm Child Psychol 26:279–291CrossRefPubMed
62.
Zurück zum Zitat Tremblay RE, Loeber R, Gagnon C et al (1991) Disruptive boys with stable and unstable high fighting behavior patterns during junior elementary school. J Abnorm Child Psychol 19:285–300CrossRefPubMed Tremblay RE, Loeber R, Gagnon C et al (1991) Disruptive boys with stable and unstable high fighting behavior patterns during junior elementary school. J Abnorm Child Psychol 19:285–300CrossRefPubMed
63.
66.
Zurück zum Zitat Loeber R, Wung P, Keenan K, Giroux B, Stouthamer-Loeber M, Van Kammen WB, Maugham B (1993) Developmental pathways in disruptive child behavior. Dev Psychopathol 5(1–2):103–133 Loeber R, Wung P, Keenan K, Giroux B, Stouthamer-Loeber M, Van Kammen WB, Maugham B (1993) Developmental pathways in disruptive child behavior. Dev Psychopathol 5(1–2):103–133
69.
Zurück zum Zitat Brooks-Gunn J, Warren MP, Rosso J, Gargiulo J (1987) Validity of self-report measures of girls’ pubertal status. Child Dev 58:829–841CrossRefPubMed Brooks-Gunn J, Warren MP, Rosso J, Gargiulo J (1987) Validity of self-report measures of girls’ pubertal status. Child Dev 58:829–841CrossRefPubMed
70.
Zurück zum Zitat Wilson BN, Kaplan BJ, Crawford SG et al (2000) Reliability and validity of a parent questionnaire on childhood motor skills. Am J Occup Ther 54:484–493CrossRefPubMed Wilson BN, Kaplan BJ, Crawford SG et al (2000) Reliability and validity of a parent questionnaire on childhood motor skills. Am J Occup Ther 54:484–493CrossRefPubMed
73.
Zurück zum Zitat Goldberg LR (1992) The development of markers for the Big-Five factor structure. Psychol Assess 4:26CrossRef Goldberg LR (1992) The development of markers for the Big-Five factor structure. Psychol Assess 4:26CrossRef
75.
Zurück zum Zitat Polanczyk G, Caspi A, Houts R et al (2010) Implications of extending the ADHD age-of-onset criterion to age 12: results from a prospectively studied birth cohort. J Am Acad Child Adolesc Psychiatry 49:210–216PubMed Polanczyk G, Caspi A, Houts R et al (2010) Implications of extending the ADHD age-of-onset criterion to age 12: results from a prospectively studied birth cohort. J Am Acad Child Adolesc Psychiatry 49:210–216PubMed
76.
Zurück zum Zitat Wechsler D (2000) WAIS-III Nederlandstalige bewerking. Technische handleiding. The Psychological Corporation, London Wechsler D (2000) WAIS-III Nederlandstalige bewerking. Technische handleiding. The Psychological Corporation, London
77.
Zurück zum Zitat Wechsler D (2002) WISC-III Handleiding. The Psychological Corporation, London Wechsler D (2002) WISC-III Handleiding. The Psychological Corporation, London
78.
Zurück zum Zitat Logan GD, Cowan WB, Davis KA (1984) On the ability to inhibit simple and choice reaction time responses: a model and a method. J Exp Psychol Hum Percept Perform 10:276–291CrossRefPubMed Logan GD, Cowan WB, Davis KA (1984) On the ability to inhibit simple and choice reaction time responses: a model and a method. J Exp Psychol Hum Percept Perform 10:276–291CrossRefPubMed
81.
Zurück zum Zitat De Sonneville L (1999) Amsterdam neuropsychological tasks: a computer-aided assessment program. Computers in psychology De Sonneville L (1999) Amsterdam neuropsychological tasks: a computer-aided assessment program. Computers in psychology
84.
Zurück zum Zitat Brus BT, Voeten M (1973) Een-Minuut-Test. Vorm A en B. Harcourt Test. Lisse, The Netherlands Brus BT, Voeten M (1973) Een-Minuut-Test. Vorm A en B. Harcourt Test. Lisse, The Netherlands
87.
Zurück zum Zitat Knutson B, Fong GW, Adams CM et al (2001) Dissociation of reward anticipation and outcome with event-related fMRI. NeuroReport 12:3683–3687CrossRefPubMed Knutson B, Fong GW, Adams CM et al (2001) Dissociation of reward anticipation and outcome with event-related fMRI. NeuroReport 12:3683–3687CrossRefPubMed
91.
Zurück zum Zitat Henkelman RM (1985) Measurement of signal intensities in the presence of noise in MR images. Med Phys 12:232–233CrossRefPubMed Henkelman RM (1985) Measurement of signal intensities in the presence of noise in MR images. Med Phys 12:232–233CrossRefPubMed
92.
Zurück zum Zitat Filippini N, MacIntosh BJ, Hough MG et al (2009) Distinct patterns of brain activity in young carriers of the APOE-ε4 allele. Proc Natl Acad Sci USA 106:7209–7214CrossRefPubMedCentralPubMed Filippini N, MacIntosh BJ, Hough MG et al (2009) Distinct patterns of brain activity in young carriers of the APOE-ε4 allele. Proc Natl Acad Sci USA 106:7209–7214CrossRefPubMedCentralPubMed
93.
Metadaten
Titel
The NeuroIMAGE study: a prospective phenotypic, cognitive, genetic and MRI study in children with attention-deficit/hyperactivity disorder. Design and descriptives
verfasst von
Daniel von Rhein
Maarten Mennes
Hanneke van Ewijk
Annabeth P. Groenman
Marcel P. Zwiers
Jaap Oosterlaan
Dirk Heslenfeld
Barbara Franke
Pieter J. Hoekstra
Stephen V. Faraone
Catharina Hartman
Jan Buitelaar
Publikationsdatum
01.03.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
European Child & Adolescent Psychiatry / Ausgabe 3/2015
Print ISSN: 1018-8827
Elektronische ISSN: 1435-165X
DOI
https://doi.org/10.1007/s00787-014-0573-4

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