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European Child & Adolescent Psychiatry

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09.02.2017 | Original Contribution

Abnormal functional connectivity strength in patients with adolescent-onset schizophrenia: a resting-state fMRI study

verfasst von: Shuai Wang, Yajing Zhan, Yan Zhang, Luxian Lv, Renrong Wu, Jingping Zhao, Wenbin Guo

Erschienen in: European Child & Adolescent Psychiatry | Ausgabe 7/2017

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Abstract

Structural and functional abnormalities were reported in the brain of patients with adolescent-onset schizophrenia (AOS). However, evidence of abnormal functional connectivity of the brain in AOS patients is limited. Thus, we analyzed the resting-state functional magnetic resonance scans of 48 drug-naive AOS patients and 31 healthy controls to determine their functional connectivity strength (FCS) and examined if FCS abnormalities were correlated with clinical characteristics. Compared with healthy controls, AOS patients showed significantly increased FCS in the left cerebellum VI and right inferior frontal gyrus/insula. A positive correlation was observed between FCS values in the right inferior frontal gyrus/insula and general psychopathology scores of positive and negative syndrome scale. Results suggest that functional connectivity pattern is disrupted in drug-naive AOS patients. The FCS values in this abnormal region have potential for evaluating the disease severity.

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Titel: Abnormal functional connectivity strength in patients with adolescent-onset schizophrenia: a resting-state fMRI study
verfasst von: Shuai Wang
Yajing Zhan
Yan Zhang
Luxian Lv
Renrong Wu
Jingping Zhao
Wenbin Guo
Publikationsdatum: 09.02.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: European Child & Adolescent Psychiatry / Ausgabe 7/2017
Print ISSN: 1018-8827
Elektronische ISSN: 1435-165X
DOI: https://doi.org/10.1007/s00787-017-0958-2

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Abnormal functional connectivity strength in patients with adolescent-onset schizophrenia: a resting-state fMRI study

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