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Recent advance in molecular angiogenesis in glioblastoma: the challenge and hope for anti-angiogenic therapy

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Abstract

Glioblastoma (GBM) is the most highly malignant brain tumor in the human central nerve system. In this paper, we review new and significant molecular findings on angiogenesis and possible resistance mechanisms. Expression of a number of genes and regulators has been shown to be upregulated in GBM microvessel cells, such as interleukin-8, signal transducer and activator of transcription 3, Tax-interacting protein-1, hypoxia induced factor-1 and anterior gradient protein 2. The regulator factors that may strongly promote angiogenesis by promoting endothelial cell metastasis, changing the microenvironment, enhancing the ability of resistance to anti-angiogenic therapy, and that inhibit angiogenesis are reviewed. Based on the current knowledge, several potential targets and strategies are proposed for better therapeutic outcomes, such as its mRNA interference of DII4-Notch signaling pathway and depletion of b1 integrin expression. We also discuss possible mechanisms underlying the resistance to anti-angiogenesis and future directions and challenges in developing new targeted therapy for GBM.

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Acknowledgments

This work was supported by the National Natural Scientific Foundation of China (No. 81141088), Research Fund for Excellent Young and Middle-aged Scientists of Shandong Province (No. 2004BS02010). JL was supported by North Shore-LIJ Cancer Institute.

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  1. Department of Neurosurgery, Qilu Hospital of Shandong University, Brain Science Research Institute of Shandong University, Jinan, 250012, People’s Republic of China

    Meng Zhang, Gengfan Ye & Yunyan Wang

  2. Department of Pathology and Laboratory Medicine, North Shore-Long Island Jewish Health System, Lake Success, NY, USA

    Jianyi Li

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Zhang, M., Ye, G., Li, J. et al. Recent advance in molecular angiogenesis in glioblastoma: the challenge and hope for anti-angiogenic therapy. Brain Tumor Pathol 32, 229–236 (2015). https://doi.org/10.1007/s10014-015-0233-5

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