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Erschienen in: neurogenetics 1/2013

01.02.2013 | Short Communication

The SETX missense variation spectrum as evaluated in patients with ALS4-like motor neuron diseases

verfasst von: Larissa Arning, Jörg T. Epplen, Elisa Rahikkala, Corinna Hendrich, Albert C. Ludolph, Anne-Dorte Sperfeld

Erschienen in: neurogenetics | Ausgabe 1/2013

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Abstract

Mutations in the senataxin (SETX) gene can cause amyotrophic lateral sclerosis 4 (ALS4), an autosomal dominant form of juvenile onset amyotrophic lateral sclerosis, or result in autosomal recessive ataxia with oculomotor apraxia type 2. Great caution regarding the possible disease causation, especially of missense variations, has to be taken. Here, we evaluated the significance of all previously reported SETX missense mutations as well as six newly identified variations in 54 patients suspected of having ALS4. Yet, epidemiologic and in silico evidence indicates that all newly identified variations and two previously published ALS4-related missense variations (C1554G and I2547T) are most likely non-pathogenic, demonstrating the problems of interpretation of SETX missense alleles in the absence of functional assays.
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Metadaten
Titel
The SETX missense variation spectrum as evaluated in patients with ALS4-like motor neuron diseases
verfasst von
Larissa Arning
Jörg T. Epplen
Elisa Rahikkala
Corinna Hendrich
Albert C. Ludolph
Anne-Dorte Sperfeld
Publikationsdatum
01.02.2013
Verlag
Springer-Verlag
Erschienen in
neurogenetics / Ausgabe 1/2013
Print ISSN: 1364-6745
Elektronische ISSN: 1364-6753
DOI
https://doi.org/10.1007/s10048-012-0347-4

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