Erschienen in:
01.02.2007 | Original article
Pulmonary involvement in ankylosing spondylitis
verfasst von:
Percival D. Sampaio-Barros, Elza Maria F. P. Cerqueira, Sílvio M. Rezende, Lucimara Maeda, Roseneide A. Conde, Verônica A. Zanardi, Manoel Barros Bértolo, José Ribeiro de Menezes Neto, Adil M. Samara
Erschienen in:
Clinical Rheumatology
|
Ausgabe 2/2007
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Abstract
This is a prospective study analyzing 52 asymptomatic, consecutive patients with ankylosing spondylitis (AS), who submitted to a pulmonary investigation that included plain chest radiography, pulmonary function test (PFT), and thoracic high-resolution computed tomography (HRCT). The results were compared according to sex, race, dorsal spine involvement, thoracic diameter, smoking status, and HLA-B27. There were four patients (8%) with an altered plain chest radiograph. PFT presented a restrictive pattern in 52% of the patients. Thoracic HRCT showed abnormalities in 21 patients (40%), predominantly nonspecific linear parenchymal opacities (19%), lymphadenopathy (12%), emphysema (10%), bronchiectasis (8%), and pleural involvement (8%). Linear parenchymal opacities were associated with a smoking history (p=0.026) and dorsal spine involvement (p=0.032). HLA-B27 was not associated with any abnormality. A lower thoracic diameter was observed in patients with dorsal spine involvement (p=0.0001), restrictive pattern at PFT (p=0.023), and linear parenchymal opacities (p=0.015). The study concluded that nonspecific subclinical pulmonary involvement is frequent in AS.