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Clinical Rheumatology

Erschienen in:

01.07.2007 | Original Article

Neridronate inhibits angiogenesis in vitro and in vivo

verfasst von: D. Ribatti, B. Nico, D. Mangieri, N. Maruotti, V. Longo, A. Vacca, F. P. Cantatore

Erschienen in: Clinical Rheumatology | Ausgabe 7/2007

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Abstract

The effects of the amino-bisphosphonate neridronate on endothelial cell functions involved in angiogenesis, namely, proliferation and morphogenesis on Matrigel were tested in vitro, whereas its effects on angiogenesis were studied in vivo, by using the chick embryo chorioallantoic membrane (CAM) assay. In vitro, neridronate inhibited endothelial cell proliferation in a dose-dependent fashion, peaking at 30 μM. At the same concentration, neridronate inhibited fibroblast growth factor-2 (FGF-2)-induced capillary-like tube formation in the morphogenesis assay on Matrigel. In vivo, when tested in the CAM assay, neridronate again displayed the capability to inhibit FGF-2-induced angiogenesis. Overall, these results suggest that anti-angiogenesis by neridronate could be used to treat a wide spectrum of angiogenesis-dependent diseases, including certain chronic inflammatory diseases and cancer.

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Titel: Neridronate inhibits angiogenesis in vitro and in vivo
verfasst von: D. Ribatti
B. Nico
D. Mangieri
N. Maruotti
V. Longo
A. Vacca
F. P. Cantatore
Publikationsdatum: 01.07.2007
Verlag: Springer-Verlag
Erschienen in: Clinical Rheumatology / Ausgabe 7/2007
Print ISSN: 0770-3198
Elektronische ISSN: 1434-9949
DOI: https://doi.org/10.1007/s10067-006-0455-3

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