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01.02.2009 | Brief Report

Association of IL-18 gene polymorphism (−137C) with arthritis manifestations in SLE: combined effect with IFN gamma gene polymorphism (+874A)

verfasst von: Nattiya Hirankarn, Marut Tangwattanachuleeporn, Jongkonnee Wongpiyabovorn, Jeerapat Wongchinsri, Yingyos Avihingsanon

Erschienen in: Clinical Rheumatology | Ausgabe 2/2009

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Abstract

We analyzed the association between single nucleotide polymorphisms in IL-12 and IL-18 genes in disease susceptibility and severity of SLE in Thais. A weak association was observed between A allele of the IL-12 gene at the 3′ untranslated region in SLE patients with proteinuria (OR = 1.89, 95% CI = 1.05–3.40, P = 0.02, Pc = 0.06). In addition, we found a significant association between C allele of IL-18 (−137) with arthritis (OR = 6.88, 95% CI = 1.54–42.93, P = 0.003, Pc = 0.009). The presence of one C allele (C/C+C/G) was associated with significant OR of 8.72 (95% CI = 1.83–56.71, P = 0.001, Pc = 0.003). Interestingly, we found the combined effect between the G/C genotype of IL-18 (−137) and the A/A genotype of IFNG (+874) gene causing susceptibility of arthritis in SLE patients (OR = 13.22, 95% CI = 1.56–291.66, P = 0.004).

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Titel: Association of IL-18 gene polymorphism (−137C) with arthritis manifestations in SLE: combined effect with IFN gamma gene polymorphism (+874A)
verfasst von: Nattiya Hirankarn
Marut Tangwattanachuleeporn
Jongkonnee Wongpiyabovorn
Jeerapat Wongchinsri
Yingyos Avihingsanon
Publikationsdatum: 01.02.2009
Verlag: Springer-Verlag
Erschienen in: Clinical Rheumatology / Ausgabe 2/2009
Print ISSN: 0770-3198
Elektronische ISSN: 1434-9949
DOI: https://doi.org/10.1007/s10067-008-1036-4

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Association of IL-18 gene polymorphism (−137C) with arthritis manifestations in SLE: combined effect with IFN gamma gene polymorphism (+874A)

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