Erschienen in:
01.03.2015 | Original Article
Spectrum of infections and outcome among hospitalized South Africans with systemic lupus erythematosus
verfasst von:
Thozama Dubula, Girish M. Mody
Erschienen in:
Clinical Rheumatology
|
Ausgabe 3/2015
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Abstract
Our aim was to determine reasons for admission, the prevalence and spectrum of infections, and the outcomes in a multiethnic cohort of hospitalized systemic lupus erythematosus (SLE) patients in Durban, South Africa. We reviewed the records of hospitalized SLE patients seen over a 79-month period; the demographic data, clinical manifestations, laboratory findings, reasons for admission, nature of infection, and outcome were recorded. Our 167 patients, comprising 59.3 % Indians, 33.5 % African Blacks, 5.4 % Coloreds, and 1.8 % Whites, had 327 admissions. Active disease and infections accounted for 218 (66.7 %) and 115 (35.2 %) admissions respectively, with 58 (17.7 %) due to both active disease and infection. Features of active disease were mucocutaneous 33.0 %, hematological 30.3 %, renal 28.9 %, and vasculitis 27.1 %. Overall, 83 patients (49.7 %) had 155 infections; pneumonia (36.8 %), cutaneous sepsis (18.1 %), tuberculosis (13.5 %), urinary tract infections (12.9 %), and septicemia (7.1 %) were the most common. The organisms commonly isolated were Staphylococcus aureus 25.4 %, Escherichia coli 20.3 %, and Klebsiella species and Mycobacterium tuberculosis in 13.6 % each. Serositis (odds ratio (OR) = 2.7, p = 0.005) and seizures (OR = 4.8, p = 0.007) were associated with increased risk of infection. Twenty-four (14.4 %) patients died from infection and active disease; the patients who died had higher SLEDAI scores (p = 0.02) and longer duration of hospitalization (p = 0.03) but no significant associations on multiple logistic regression analysis. Bacterial infections, including tuberculosis, are common in SLE, and they are a major cause of mortality.