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Erschienen in: Clinical Rheumatology 4/2017

24.01.2017 | Original Article

Analysis of killer cell immunoglobulin-like receptors (KIRs) and their HLA ligand genes polymorphisms in Iranian patients with systemic sclerosis

verfasst von: Mahdi Mahmoudi, Faranak Fallahian, Soheila Sobhani, Shima Ghoroghi, Ahmadreza Jamshidi, Shiva Poursani, Masoumeh Dolati, Zahra Hosseinpour, Farhad Gharibdoost

Erschienen in: Clinical Rheumatology | Ausgabe 4/2017

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Abstract

Genetic factors have a great role in the pathogenesis of autoimmune diseases by cooperating with environmental stimuli. Killer immunoglobulin-like receptors (KIRs) are cell surface proteins on NK cells whose association with major histocompatibility complex-I regulates their killing function. The aim of this study was to provide information on the possible association between KIR and human leukocyte antigen (HLA) genes with systemic sclerosis disease in Iranian population. A total of 279 systemic sclerosis patients and 451 healthy controls were enrolled in this case-control study in order to determine the presence or absence of 19 KIR genes and 6 specific HLA class I ligands. DNA was analyzed by polymerase chain reaction using the specific sequence primer method (PCR-SSP). Among 11 discovered KIR genotypes, 6 genotypes showed a considerable role and 4 genotypes could preclude the risk of systemic sclerosis (SSc) disease. The gene-gene interactions were also analyzed, and significant confounding effects were seen between involved genes in these two combinations: “KIR3DL1; HLA-BW4-Thr80” and “KIR3DL1 -HLA-BW4-A1.” None of single KIR genes showed significant effect on the risk of SSc. We conclude that there is an important relationship between KIR genes and their HLA ligands with incidence rate of systemic sclerosis in Iranian population. The powerful role of a number of discovered KIR/HLA compounds such as activating KIR genotype 3 and HLA-BW4-A1 confirmed the provocative hypothesis of the interplay between activating or inhibitory KIR genes with HLA ligands as a critical index of systemic sclerosis predisposition.
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Metadaten
Titel
Analysis of killer cell immunoglobulin-like receptors (KIRs) and their HLA ligand genes polymorphisms in Iranian patients with systemic sclerosis
verfasst von
Mahdi Mahmoudi
Faranak Fallahian
Soheila Sobhani
Shima Ghoroghi
Ahmadreza Jamshidi
Shiva Poursani
Masoumeh Dolati
Zahra Hosseinpour
Farhad Gharibdoost
Publikationsdatum
24.01.2017
Verlag
Springer London
Erschienen in
Clinical Rheumatology / Ausgabe 4/2017
Print ISSN: 0770-3198
Elektronische ISSN: 1434-9949
DOI
https://doi.org/10.1007/s10067-016-3526-0

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