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Observational study of sleep-related disorders in Italian patients with Parkinson’s disease: usefulness of the Italian version of Parkinson’s disease sleep scale

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Abstract

Sleep disturbances are common in patients with Parkinson’s disease (PD). We aimed to evaluate prevalence and severity of nighttime sleep disturbances in Italian PD patients and to validate the Italian version of the Parkinson’s disease sleep scale. A total of 221 PD patients and 57 healthy controls participated in a cross-sectional study with retest. PDSS, Epworth Sleepiness Scale (ESS), Hamilton Depression Rating Scale, Unified Parkinson’s Disease Rating Scale (UPDRS), and Hoehn and Yahr staging were applied. PDSS total and individual items scores from patients were significantly lower than those in controls. Internal consistency of PDSS scale was satisfactory and intraclass correlation coefficient for test–retest reliability was 0.96 for total PDSS score. A significant negative correlation was found between total PDSS and ESS scores, and between total PDSS and HDRS scores. PDSS scores were also related to UPDRS sections II, III and IV, and H&Y stage. PDSS and ESS scores were not related to levodopa equivalent dose. Daytime sleepiness, depressive symptoms and disease severity correlate with sleep disturbances in Italian PD patients. The PDSS is a valid and reliable tool to evaluate sleep disturbances in Italian patients.

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Authors and Affiliations

  1. Department of Neurological Sciences, University of Naples, Federico II, Naples, Italy

    M. T. Pellecchia & P. Barone

  2. Department for Parkinson’s Disease, IRCCS San Camillo, Venice, Italy

    A. Antonini

  3. Department of Neuroscience, University of Pisa, Pisa, Italy

    U. Bonuccelli

  4. Department of Neurology and Psychiatry and Neuromed Institute, “Sapienza” University of Rome, Rome, Italy

    G. Fabbrini

  5. Sleep Disorder Center, Division of Neurosciences, Università Vita-Salute San Raffaele, Milan, Italy

    L. Ferini Strambi

  6. Department of Neurology, Institute of Research and Medical Care, IRCCS San Raffaele Roma, Rome, Italy

    F. Stocchi

  7. Pfizer Italia, Medical Department, Rome, Italy

    A. Battaglia

  8. Center for Diagnosis and Treatment of Neurodegenerative Disorders, University of Salerno, Salerno, Italy

    P. Barone

Authors
  1. M. T. Pellecchia
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  2. A. Antonini
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  3. U. Bonuccelli
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  4. G. Fabbrini
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  5. L. Ferini Strambi
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  6. F. Stocchi
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  7. A. Battaglia
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  8. P. Barone
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Corresponding author

Correspondence to P. Barone.

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Pellecchia, M.T., Antonini, A., Bonuccelli, U. et al. Observational study of sleep-related disorders in Italian patients with Parkinson’s disease: usefulness of the Italian version of Parkinson’s disease sleep scale. Neurol Sci 33, 689–694 (2012). https://doi.org/10.1007/s10072-011-0826-7

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  • DOI: https://doi.org/10.1007/s10072-011-0826-7

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