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Erschienen in: Neurological Sciences 12/2014

01.12.2014 | Original Article

Serum phosphate concentration and incidence of stroke: a systemic review and meta-analysis

verfasst von: Jing-Wei Li, Cui Xu, Ying-Bin Xiao

Erschienen in: Neurological Sciences | Ausgabe 12/2014

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Abstract

Elevated serum phosphate is associated with cardiovascular and total mortality in patients with kidney diseases and healthy individuals. But whether serum phosphate is associated with stroke is controversial. We searched PubMed and Embase from January 1, 1970 to May 9, 2014 with keywords such as “serum phosphate”, “serum phosphorus”, and “stroke”. Dose–response meta-analysis was conducted. A restricted cubic spline model was used, and then we estimated pooled RR using generalized least square regression taking into account the correlation among categories of each study. Five studies with a total of 32,608 patients were included. We identified a linear relationship between serum phosphate and risk of stroke (P for non-linearity = 0.5258). The RR of phosphate (1 mg/dL) for stroke was 1.00 (95 % CI 0.97–1.05), similar results were observed in subgroup analysis. A linear relationship between serum phosphate and risk of stroke is identified. There is no association between serum level of phosphate and stroke.
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Metadaten
Titel
Serum phosphate concentration and incidence of stroke: a systemic review and meta-analysis
verfasst von
Jing-Wei Li
Cui Xu
Ying-Bin Xiao
Publikationsdatum
01.12.2014
Verlag
Springer Milan
Erschienen in
Neurological Sciences / Ausgabe 12/2014
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-014-1850-1

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