Erschienen in:
01.01.2015 | Original Article
Leptomeningeal metastasis from solid tumors: a diagnostic and therapeutic challenge
verfasst von:
Maria Grazia Passarin, Teodoro Sava, Jenny Furlanetto, Annamaria Molino, Rolando Nortilli, Anna Maria Musso, Marta Zaninelli, Tiziano Franceschi, Daniele Orrico, Sabrina Marangoni, Cristina Dealis, Claudio Graiff, Rodella Filippo, Salvatore Grisanti, Edda Simoncini, Lucia Vassalli, Alfredo Berruti, Rebecca Pedersini
Erschienen in:
Neurological Sciences
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Ausgabe 1/2015
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Abstract
Leptomeningeal metastasis (LM) is a severe complication in the natural history of malignancies that occurs in 4–15 % of patients (pts) with solid tumors. Clinical presentation, cerebrospinal fluid cytology (CSF), and gadolinium magnetic resonance imaging (gdMRI) of the brain and spine are the methods routinely used to diagnose LM. Treatment encompasses involved-field radiotherapy of bulky or symptomatic disease sites and chemotherapy; however, no standard therapy has been established yet. We collected and reviewed retrospectively the clinical, pathological, radiological findings as well as the outcomes of 50 consecutive patients with LM from solid tumors to determine whether the diagnostic modalities and therapeutic procedures affected the outcomes. The results of this study confirm the role of gdMRI in the diagnosis of LM in clinical practice and suggest that an aggressive treatment may improve survival in patients with this debilitating and increasingly frequent neurological complication.