Skip to main content

Advertisement

SpringerLink
Log in

Arterial stiffness and impaired renal function in patients with Alzheimer’s disease

  • Original Article
  • Published:
Neurological Sciences Aims and scope Submit manuscript

Abstract

Impaired renal function is regarded as a risk factor for vascular disease, and is associated with an increasing pulse wave velocity. Both renal dysfunction and arterial stiffness are associated with cognitive impairment and dementia. However, there have been few studies that have evaluated the relationship between albuminuria and arterial stiffness and Alzheimer’s disease (AD). We investigated renal dysfunction and arterial stiffness in AD, as compared to normal controls, patients with subjective memory impairment (SMI), and patients with mild cognitive impairment (MCI). Case–control comparisons were made between 29 patients with AD, 27 with MCI, 14 with SMI, and 25 healthy controls. All patients underwent clinical and neuropsychological assessments. The urine albumin/creatinine ratio and estimated glomerular filtration rate (eGFR) were determined. Pulse wave velocity and the ankle-brachial index were used to evaluate arterial stiffness. The urine albumin/creatinine ratio and eGFR were significantly different in patients with AD, compared with the results from cognitive normal controls. The pulse wave velocity was increased and the ankle-brachial index was decreased in AD. The eGFR was well correlated with other indices and decreasing eGFR was independently associated with cognitive decline. In conclusion, albuminuria, a decreased glomerular filtration rate, an increased pulse wave velocity, and a decreased ankle-brachial index were associated with AD. These finding suggests that impaired renal functions and arterial stiffness are related to AD, in which a vascular mechanism plays a prominent role in the cognitive dysfunction associated with the disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Zhang QL, Koenig W, Raum E, Stegmaier C, Brenner H, Rothenbacher D (2009) Epidemiology of chronic kidney disease: results from a population of older adults in Germany. Prev Med 48(2):122–127

    Article  PubMed  Google Scholar 

  2. Currie G, Delles C (2013) Proteinuria and its relation to cardiovascular disease. Int J Nephrol Renovasc Dis 7:13–24

    PubMed  PubMed Central  Google Scholar 

  3. Ninomiya T (2013) Risk of stroke in kidney disease. Contrib Nephrol 179:58–66

    Article  PubMed  Google Scholar 

  4. Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY (2004) Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med 351(13):1296–1305

    Article  CAS  PubMed  Google Scholar 

  5. Elias MF, Dore GA, Davey A (2013) Kidney disease and cognitive function. Contrib Nephrol 179:42–57

    Article  PubMed  Google Scholar 

  6. Seliger SL, Siscovick DS, Stehman-Breen CO, Gillen DL, Fitzpatrick A, Bleyer A, Kuller LH (2004) Moderate renal impairment and risk of dementia among older adults: the Cardiovascular Health Cognition Study. J Am Soc Nephrol 15(7):1904–1911

    Article  PubMed  Google Scholar 

  7. Helmer C, Stengel B, Metzger M, Froissart M, Massy ZA, Tzourio C, Berr C, Dartigues JF (2011) Chronic kidney disease, cognitive decline, and incident dementia: the 3C study. Neurology 77(23):2043–2051

    Article  CAS  PubMed  Google Scholar 

  8. Sasaki Y, Marioni R, Kasai M, Ishii H, Yamaguchi S, Meguro K (2011) Chronic kidney disease: a risk factor for dementia onset: a population-based study. The Osaki-Tajiri Project. J Am Geriatr Soc 59(7):1175–1181

    Article  PubMed  Google Scholar 

  9. Barzilay JI, Fitzpatrick AL, Luchsinger J, Yasar S, Bernick C, Jenny NS, Kuller LH (2008) Albuminuria and dementia in the elderly: a community study. Am J Kidney Dis 52(2):216–226

    Article  PubMed  PubMed Central  Google Scholar 

  10. Weiner DE, Bartolomei K, Scott T, Price LL, Griffith JL, Rosenberg I, Levey AS, Folstein MF, Sarnak MJ (2009) Albuminuria, cognitive functioning, and white matter hyperintensities in homebound elders. Am J Kidney Dis 53(3):438–447

    Article  PubMed  PubMed Central  Google Scholar 

  11. Jassal SK, Kritz-Silverstein D, Barrett-Connor E (2010) A prospective study of albuminuria and cognitive function in older adults: the Rancho Bernardo study. Am J Epidemiol 171(3):277–286

    Article  PubMed  PubMed Central  Google Scholar 

  12. Buchman AS, Tanne D, Boyle PA, Shah RC, Leurgans SE, Bennett DA (2009) Kidney function is associated with the rate of cognitive decline in the elderly. Neurology 73(12):920–927

    Article  PubMed  PubMed Central  Google Scholar 

  13. Higuchi M, Chen R, Abbott RD, Bell C, Launer L, Ross GW, Petrovitch H, Masaki K (2015) Mid-life proteinuria and late-life cognitive function and dementia in elderly men: the Honolulu-Asia Aging Study. Alzheimer Dis Assoc Disord 29(3):200–205

    Article  PubMed  Google Scholar 

  14. Yoon HE, Shin DI, Kim SJ, Koh ES, Hwang HS, Chung S, Shin SJ (2013) Brachial-ankle pulse wave velocity predicts decline in renal function and cardiovascular events in early stages of chronic kidney disease. Int J Med Sci 10(11):1430–1436

    Article  PubMed  PubMed Central  Google Scholar 

  15. Chen FA, Yang CY, Yang WC, Chen JY, Ng YY, Li SY, Liu WS, Cheng ST, Wang YJ, Lin CC (2012) Ankle-brachial index is a powerful predictor of renal outcome and cardiovascular events in patients with chronic kidney disease. ScientificWorldJournal 2012:238494. doi:10.1100/2012/238494

    PubMed  PubMed Central  Google Scholar 

  16. Zhong W (2011) Pulse wave velocity in association with cognitive function. N Am J Med Sci 4(4):212–216

    Article  Google Scholar 

  17. Hanon O, Haulon S, Lenoir H, Seux ML, Rigaud AS, Safar M, Girerd X, Forette F (2005) Relationship between arterial stiffness and cognitive function in elderly subjects with complaints of memory loss. Stroke 36(10):2193–2197

    Article  PubMed  Google Scholar 

  18. Waldstein SR, Rice SC, Thayer JF, Najjar SS, Scuteri A, Zonderman AB (2008) Pulse pressure and pulse wave velocity are related to cognitive decline in the Baltimore Longitudinal Study of Aging. Hypertension 51(1):99–104

    Article  CAS  PubMed  Google Scholar 

  19. McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR Jr, Kawas CH, Klunk WE, Koroshetz WJ, Manly JJ, Mayeux R, Mohs RC, Morris JC, Rossor MN, Scheltens P, Carrillo MC, Thies B, Weintraub S, Phelps CH (2011) The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 7(3):263–269

    Article  PubMed  PubMed Central  Google Scholar 

  20. American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Association, Washington, DC

    Google Scholar 

  21. Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E (1999) Mild cognitive impairment: clinical characterization and outcome. Arch Neurol 56(3):303–308

    Article  CAS  PubMed  Google Scholar 

  22. Stewart R (2012) Subjective cognitive impairment. Curr Opin Psychiatry 25(6):445–450

    Article  PubMed  Google Scholar 

  23. Kang YW, Na DL (2003) Seoul neuropsychological screening battery. Human Consulting Co, Incheon

    Google Scholar 

  24. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D (1999) A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 130(6):461–470

    Article  CAS  PubMed  Google Scholar 

  25. Hashimoto J, Aikawa T, Imai Y (2008) Large artery stiffening as a link between cerebral lacunar infarction and renal albuminuria. Am J Hypertens 21(12):1304–1309

    Article  CAS  PubMed  Google Scholar 

  26. Lambers Heerspink HJ, Brantsma AH, de Zeeuw D, Bakker SJ, de Jong PE, Gansevoort RT, PREVEND Study Group (2008) Albuminuria assessed from first-morning-void urine samples versus 24-hour urine collections as a predictor of cardiovascular morbidity and mortality. Am J Epidemiol 168(8):897–905

    Article  PubMed  Google Scholar 

  27. Witte MM, Trzepacz P, Case M, Yu P, Hochstetler H, Quinlivan M, Sundell K, Henley D (2014) Association between clinical measures and florbetapir F18 PET neuroimaging in mild or moderate Alzheimer’s disease dementia. J Neuropsychiatry Clin Neurosci 26(3):214–220

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 505, Banpo-dong, Seocho-gu, Seoul, 06591, Republic of Korea

    Yoon-Sang Oh, Joong-Seok Kim, Jeong-Wook Park, Jae-Young An, Sung Kyung Park, Yong-Soo Shim, Dong-Won Yang & Kwang-Soo Lee

Authors
  1. Yoon-Sang Oh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Joong-Seok Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jeong-Wook Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jae-Young An
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Sung Kyung Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yong-Soo Shim
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Dong-Won Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Kwang-Soo Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Joong-Seok Kim.

Ethics declarations

Conflict of interest

The authors have no conflicts of interest or financial support to report.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Oh, YS., Kim, JS., Park, JW. et al. Arterial stiffness and impaired renal function in patients with Alzheimer’s disease. Neurol Sci 37, 451–457 (2016). https://doi.org/10.1007/s10072-015-2434-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10072-015-2434-4

Keywords

Search

Navigation