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Erschienen in: Neurological Sciences 3/2018

01.03.2018 | Original Article

Comparison of odor identification among amnestic and non-amnestic mild cognitive impairment, subjective cognitive decline, and early Alzheimer’s dementia

verfasst von: Sung-Jin Park, Jee-Eun Lee, Kwang-Soo Lee, Joong-Seok Kim

Erschienen in: Neurological Sciences | Ausgabe 3/2018

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Abstract

Olfactory impairment might be an important clinical marker and predictor of Alzheimer’s disease (AD). In the present study, we aimed to compare the degree of olfactory identification impairment in each mild cognitive impairment (MCI) subtype, subjective memory impairment, and early AD dementia and assessed the relationship between olfactory identification and cognitive performance. We consecutively included 50 patients with amnestic MCI, 28 patients with non-amnestic MCI, 20 patients with mild AD, and 17 patients with subjective memory impairment (SMI). All patients underwent clinical and neuropsychological assessments. A multiple choice olfactory identification cross-cultural smell identification test was also utilized. Controlling for age and gender, olfactory impairment was significantly more severe in patients with AD and amnestic MCI compared with the results from the non-amnestic MCI and SMI groups. Higher scores on MMSE, verbal and non-verbal memory, and frontal executive function tests were significantly related to olfactory identification ability. In conclusion, olfactory identification is impaired in amnestic MCI and AD. These findings are consistent with previous studies. In amnestic MCI patients, this dysfunction is considered to be caused by underlying AD pathology.
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Metadaten
Titel
Comparison of odor identification among amnestic and non-amnestic mild cognitive impairment, subjective cognitive decline, and early Alzheimer’s dementia
verfasst von
Sung-Jin Park
Jee-Eun Lee
Kwang-Soo Lee
Joong-Seok Kim
Publikationsdatum
01.03.2018
Verlag
Springer Milan
Erschienen in
Neurological Sciences / Ausgabe 3/2018
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-018-3261-1

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