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Incidence of sarcopenia and dynapenia according to stage in patients with idiopathic Parkinson’s disease

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Abstract

Aim

In this study, the aim was to identify the incidence of sarcopenia and dynapenia according to disease stage among idiopathic Parkinson’s disease (IPD) patients and collect data to illuminate precautions related to reducing the disease load.

Method

The study was completed with 166 patients divided by stage according to modified Hoehn and Yahr (HYR) criteria and 249 healthy volunteers aged from 18 to 39 and 68 to 75 years met the inclusion criteria. In our prospective and cross-sectional study, patients with IPD according to “UK Brain Bank” diagnostic criteria had the Unified Parkinson’s Disease Rating Scale (UPDRS) and HYR scales applied. The patient and control groups had skeletal muscle mass index (SMMI), muscle power, and physical performance assessed. Diagnosis of sarcopenia used the European Working Group on Sarcopenia in Older People (EWGSOP) diagnostic criteria.

Results

In our study, in parallel with the increase in disease stage among IPD patients, the incidence of sarcopenia (led by severe sarcopenia) and dynapenia was high compared to that among the control group of the same age.

Conclusion

In the early stages of chronic progressive diseases like IPD, identification of sarcopenia and dynapenia is important considering the limitations of disease-preventive effects in treatments applied after diagnosis.

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References

  1. Torun Ş, Uysal M, Gücüyener D, Özdemir G (1995) Parkinson’s disease in Eskişehir, Turkey. Eur J Neurol 2:44–45

    Google Scholar 

  2. Xu XM, Dong MX, Feng X, Liu Y, Pan JX, Jia SY, Cao D, Wei YD (2018) Decreased serum proNGF concentration in patients with Parkinson’s disease. Neurol Sci Jan 39:91–96

    Article  Google Scholar 

  3. Rosenberg IH (1997) Sarcopenia: origins and clinical relevance. J Nutr 127:990S–991S

    Article  CAS  PubMed  Google Scholar 

  4. Rosenberg I (1989) Summary comments: epidemiological and methodological problems in determining nutritional status of older persons. Am J Clin Nutr 50:1231–1233

    Article  Google Scholar 

  5. Baumgartner RN, Koehler KM, Gallagher D, Romero L, Heymsfield SB, Ross RR, Garry PJ, Lindeman RD (1998) Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 147(8):755–763

    Article  CAS  PubMed  Google Scholar 

  6. Rosenberg IH, Roubenoff R (1995) Stalking sarcopenia. Ann Intern Med 123(9):727–728

    Article  CAS  PubMed  Google Scholar 

  7. Cawthon PM, Marshall LM, Michael Y, Dam TT, Ensrud KE, Barrett-Connor E, Orwoll ES, Osteoporotic Fractures in Men Research Group (2007) Frailty in older men: prevalence, progression, and relationship with mortality. J Am Geriatr Soc 55(8):1216–1223

    Article  PubMed  Google Scholar 

  8. Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F et al (2010) Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People. Age Ageing 39(4):412–423

    Article  PubMed Central  PubMed  Google Scholar 

  9. Newman AB, Kupelian V, Visser M, Simonsick E, Goodpaster B, Nevitt M, Kritchevsky SB, Tylavsky FA, Rubin SM, Harris TB, Health ABC Study Investigators (2003) Sarcopenia: alternative definitions and associations with lower extremity function. J Am Geriatr Soc 51(11):1602–1609

    Article  PubMed  Google Scholar 

  10. Goodpaster BH, Park SW, Harris TB, Kritchevsky SB, Nevitt M, Schwartz AV, Simonsick EM, Tylavsky FA, Visser M, Newman AB, for the Health ABC Study (2006) The loss of skeletal muscle strength, mass and quality in older adults: the health, aging and body composition study. J Gerontol A Biol Sci Med Sci 61(10):1059–1064

    Article  PubMed  Google Scholar 

  11. Bianchi L, Ferrucci L, Cherubini A, Maggio M, Bandinelli S, Savino E, Brombo G, Zuliani G, Guralnik JM, Landi F, Volpato S (2016) The predictive value of the EWGSOP definition of sarcopenia: results from the InCHIANTI study. J Gerontol A Biol Sci Med Sci 71:259–264

    Article  PubMed  Google Scholar 

  12. Barichella M, Pinelli G, Iorio L, Cassani E, Valentino A, Pusani C, Ferri V, Bolliri C, Pasqua M, Pezzoli G, Frazzitta G, Cereda E (2016) Sarcopenia and dynapenia in patients with parkinsonism. J Am Med Dir Assoc 17(7):640–646

    Article  PubMed  Google Scholar 

  13. Yürüyen M, Yavuzer H, Yavuzer S, Cengiz M, Demirdağ F, Kara Z et al (2017) Comparison of nutritional risk screening tools for predicting sarcopenia in hospitalized patients. Turk J Med Sci 47:1362–1369

    Article  Google Scholar 

  14. Yadigar S, Yavuzer H, Yavuzer S, Cengiz M, Yürüyen M, Döventaş A et al (2017) Primary sarcopenia in older people with normal nutrition. J Nutr Health Aging 21(8):849–854

    Article  Google Scholar 

  15. Cruz-Jentoft AJ, Landi F, Topinková E, Michel JP (2010) Understanding sarcopenia as a geriatric syndrome. Curr Opin Clin Nutr Metab Care 13(1):1–7

    Article  PubMed  Google Scholar 

  16. Morley JE (2008) Sarcopenia: diagnosis and treatment. J Nutr Health Aging 12(7):452–456

    Article  CAS  PubMed  Google Scholar 

  17. Janssen I (2011) The epidemiology of sarcopenia. Clin Geriatr Med 27(3):355–363

    Article  PubMed  Google Scholar 

  18. Wang C, Bai L (2012) Sarcopenia in the elderly: basic and clinical issues. Geriatr Gerontol Int 12(3):388–396

    Article  PubMed  Google Scholar 

  19. Paddon-Jones D, Short KR, Campbell WW, Volpi E, Wolfe RR (2008) Role of dietary protein in the sarcopenia of aging. Am J Clin Nutr 87(5):1562S–1566S

    Article  CAS  PubMed  Google Scholar 

  20. Jankovic J (2008) Parkinson’s disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry 79(4):368–376

    Article  CAS  PubMed  Google Scholar 

  21. Ramaker C, Marinus J, Stiggelbout AM, Van Hilten BJ (2002) Systematic evaluation of rating scales for impairment and disability in Parkinson's disease. Mov Disord 17:867–876

    Article  PubMed  Google Scholar 

  22. Hoehn MM, Yahr MD (1967) Parkinsonism: onset, progression and mortality. Neurology 17:427–442

    Article  CAS  PubMed  Google Scholar 

  23. Lauretani F, Russo CR, Bandinelli S, Bartali B, Cavazzini C, Di Iorio A, Corsi AM, Rantanen T, Guralnik JM, Ferrucci L (1985) Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia. J Appl Physiol. 2003 95(5):1851–1860

    Article  Google Scholar 

  24. Trojano L, Papagno C (2018) Cognitive and behavioral disorders in Parkinson’s disease: an update. II: behavioral disorders. Neurol Sci 39(1):53–61

    Article  PubMed  Google Scholar 

  25. Gazibara T, Kisic-Tepavcevic D, Svetel M, Tomic A, Stankoviç İ, Kostic V, Pekmezovic T (2017) Dynamics of change in self-reported disability among persons with Parkinson’s disease after 2 years of follow-up. Neurol Sci 38:1415–1421

    Article  PubMed  Google Scholar 

  26. Morley JE (2002) Pathophysiology of anorexia. Clin Geriatr Med 18:661–663

    Article  PubMed  Google Scholar 

  27. Seiler WO (2001) Clinical pictures of malnutrition in ill elderly subjects. Nutrition 17(6):496–498

    Article  CAS  PubMed  Google Scholar 

  28. Saji N, Arai H, Sakurai T, Toba K (2016) Frailty and sarcopenia: a new bridge to dementia. Nihon Rinsho 74(3):505–509

    PubMed  Google Scholar 

  29. Bahat G, Tufan A, Tufan F, Kılıc C, Akpinar S, Kose M (2016) Cut-off points to identify sarcopenia according to European Working Group on Sarcopenia in Older People (EWGSOP) definition. Clin Nutr 2(6):35

    Google Scholar 

  30. Kim H, Hirano H, Edahiro A, Ohara Y, Watanebe Y, Kojima N, Kim M, Hosoi E, Yoshida Y, Yoshida H, Shinkai S (2016) Sarcopenia: prevalence and associated factors based on different suggested definitions in community-dwelling older adults. Geriatr Gerontol Int 16(Suppl 1):110–122

    Article  PubMed  Google Scholar 

  31. Bahat G, Tufan A, Tufan F, Karan MA (2017) Significance of population differences and the methodology in determining the muscle mass cut-off points for sarcopenia. Geriatr Gerontol Int 17(3):521–522

    Article  PubMed  Google Scholar 

  32. Van der Marck MA, Dicke HC, Uc EY, Kentin ZH, Borm GF, Bloem BR, Overeem S, Munneke M (2012) Body mass index in Parkinson’s disease: a meta-analysis. Parkinsonism Relat Disord 18(3):263–267

    Article  PubMed  Google Scholar 

  33. Davide L, Vetrano DL, Pisciotta MS, Laudisio A, Lo Monaco MR, Onder G, Brandi V et al (2018) Sarcopenia in Parkinson disease: comparison of different criteria and association with disease severity. J Am Med Dir Assoc S1525-8610(17):30683–30687

    Google Scholar 

  34. Drey M, Hassman SE, Krenovsky JP, Hobert MA, Straub S, Elshehabi M et al (2017) Associations between early markers of Parkinson’s disease and sarcopenia. Front Aging Neurosci 9:53 eCollection 2017

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  35. Tolea MI, Galvin JE (2015) Sarcopenia and impairment in cognitive and physical performance. Clin İnterv Aging 10:663–671

    Article  PubMed Central  PubMed  Google Scholar 

  36. Lee YS, Kim SD, Kang HJ, Kim SW, Shin IS, Yoon JS, Kim JM (2017) Associations of upper arm and thigh circumferences with dementia and depression in Korean elders. Psychiatry Investig 14(2):150–157

    Article  PubMed Central  PubMed  Google Scholar 

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Correspondence to Tamer Yazar.

Ethics declarations

To complete this study with the aim of determining the incidence of sarcopenia and dynapenia among IPD patients monitored by Ordu University Education and Research Hospital and Ordu State University, permission was granted by the General Secretariate of Ordu Provincial Union of Public Hospitals and the ethics committee of Ordu University Education and Research Hospital, decision number 2017/108.

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Yazar, T., Yazar, H.O., Zayimoğlu, E. et al. Incidence of sarcopenia and dynapenia according to stage in patients with idiopathic Parkinson’s disease. Neurol Sci 39, 1415–1421 (2018). https://doi.org/10.1007/s10072-018-3439-6

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  • DOI: https://doi.org/10.1007/s10072-018-3439-6

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