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22.03.2019 | Original Article

Neuropsychiatric symptoms differently affect mild cognitive impairment and Alzheimer’s disease patients: a retrospective observational study

verfasst von: Eugenia Scaricamazza, Isabella Colonna, Giulia Maria Sancesario, Francesca Assogna, Maria Donata Orfei, Flaminia Franchini, Giuseppe Sancesario, Nicola Biagio Mercuri, Claudio Liguori

Erschienen in: Neurological Sciences | Ausgabe 7/2019

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Abstract

Alzheimer’s disease (AD) is the most common form of dementia characterized by the prevalent memory impairment. Mild cognitive impairment (MCI) may represent the early stage of AD, in particular when MCI patients show biomarkers consistent with AD pathology (MCI due to AD). Neuropsychiatric symptoms (NPS) frequently affect both MCI and AD patients. Cerebrospinal-fluid (CSF) tau and β-amyloid₄₂ (Aβ₄₂) levels are actually considered the most sensitive and specific biomarkers for AD neurodegeneration. In the present retrospective observational study, we evaluated CSF biomarkers and neuropsychological data (also including NPS measured by the neuropsychiatric inventory—NPI) in a population of patients affected by MCI due to AD compared with mild to moderate AD patients. We documented higher NPI scores in MCI compared with AD patients. In particular, sub-items related to sleep, appetite, irritability, depression, and anxiety were higher in MCI than AD. We also found the significant correlation between NPS and CSF AD biomarkers in the whole population of MCI and AD patients. Consistently, t-tau/Aβ₄₂ ratio correlated with NPS in all the MCI and AD patients. These results suggest the more prevalent occurrence of NPS in MCI patients showing AD pathology and converting to dementia than AD patients. Moreover, a more significant degree of AD neurodegeneration, featured by high t-tau/Aβ₄₂ ratio, correlated with more severe NPS, thus supposing that in MCI and AD patients a more extensive AD neurodegeneration is related to more severe behavioral disturbances.

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Titel: Neuropsychiatric symptoms differently affect mild cognitive impairment and Alzheimer’s disease patients: a retrospective observational study
verfasst von: Eugenia Scaricamazza
Isabella Colonna
Giulia Maria Sancesario
Francesca Assogna
Maria Donata Orfei
Flaminia Franchini
Giuseppe Sancesario
Nicola Biagio Mercuri
Claudio Liguori
Publikationsdatum: 22.03.2019
Verlag: Springer International Publishing
Erschienen in: Neurological Sciences / Ausgabe 7/2019
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-019-03840-4

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