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Neurological Sciences

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08.04.2019 | Original Article

Dystonin/BPAG1 modulates diabetes and Alzheimer’s disease cross-talk: a meta-analysis

verfasst von: Jack Cheng, Hsin-Ping Liu, Su-Lun Hwang, Lee-Fen Hsu, Wei-Yong Lin, Fuu-Jen Tsai

Erschienen in: Neurological Sciences | Ausgabe 8/2019

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Abstract

Dementia is one of the diabetic complications under intensive study. Alteration of synaptic adhesion protein (SAP) associates with neurological diseases, including Alzheimer’s disease. However, the regulation of SAPs in the brain of diabetes mellitus remains elusive. To pinpoint the candidate SAPs underlining the mechanism of diabetic dementia, we investigated expression profiling of SAPs in both streptozotocin (STZ)-induced diabetic mice, App^{NL-G-F/NL-G-F} mice, and amyloid precursor protein intracellular domain (AICD)-induced human neural cell line from public databases. DST (Dystonin/BPAG1) was identified upregulated in both models. Our finding suggests that DST alteration may involve in the mechanism of diabetic dementia.

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Titel: Dystonin/BPAG1 modulates diabetes and Alzheimer’s disease cross-talk: a meta-analysis
verfasst von: Jack Cheng
Hsin-Ping Liu
Su-Lun Hwang
Lee-Fen Hsu
Wei-Yong Lin
Fuu-Jen Tsai
Publikationsdatum: 08.04.2019
Verlag: Springer International Publishing
Erschienen in: Neurological Sciences / Ausgabe 8/2019
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-019-03879-3

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