Erschienen in:
01.09.2007 | Article
Coxiella burnetii infection of aortic aneurysms or vascular grafts: report of 30 new cases and evaluation of outcome
verfasst von:
E. Botelho-Nevers, P.-E. Fournier, H. Richet, F. Fenollar, H. Lepidi, C. Foucault, A. Branchereau, P. Piquet, M. Maurin, D. Raoult
Erschienen in:
European Journal of Clinical Microbiology & Infectious Diseases
|
Ausgabe 9/2007
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Abstract
Q fever is a zoonotic disease caused by Coxiella burnetii. Polymorphic, the disease may present as an acute or chronic infection. Vascular infections are the second most common form of chronic Q fever, following endocarditis. Herein, we studied the outcome of 30 new cases of aortic infection caused by C. burnetii using uni- and multivariate analyses. The outcome of ten cases previously reported by our team was also updated. Of these 40 patients, 32 had a follow-up of ≥3 years. Among them, the overall mortality was of 25% (8/32). Vascular rupture was significantly and independently (multivariate P=0.03) associated with a lethal issue, whereas vascular surgery was significantly associated with recovery (uni- and multivariate P<0.01). Our findings demonstrate the critical importance of surgery in the management of C. burnetii vascular infections.