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Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases 5/2021

03.01.2021 | COVID-19 | Review Zur Zeit gratis

COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection

verfasst von: Stephany Beyerstedt, Expedito Barbosa Casaro, Érika Bevilaqua Rangel

Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases | Ausgabe 5/2021

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Abstract

COVID-19 pandemic is caused by the novel coronavirus SARS-CoV-2. Angiotensin-converting enzyme 2 (ACE2) is not only an enzyme but also a functional receptor on cell surfaces through which SARS-CoV-2 enters the host cells and is highly expressed in the heart, kidneys, and lungs and shed into the plasma. ACE2 is a key regulator of the renin–angiotensin–aldosterone system (RAAS). SARS-CoV-2 causes ACE/ACE2 balance disruption and RAAS activation, which leads ultimately to COVID-19 progression, especially in patients with comorbidities, such as hypertension, diabetes mellitus, and cardiovascular disease. Therefore, ACE2 expression may have paradoxical effects, aiding SARS-CoV-2 pathogenicity, yet conversely limiting viral infection. This article reviews the existing literature and knowledge of ACE2 in COVID-19 setting and focuses on its pathophysiologic involvement in disease progression, clinical outcomes, and therapeutic potential.
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Metadaten
Titel
COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection
verfasst von
Stephany Beyerstedt
Expedito Barbosa Casaro
Érika Bevilaqua Rangel
Publikationsdatum
03.01.2021
Verlag
Springer Berlin Heidelberg
Schlagwort
COVID-19
Erschienen in
European Journal of Clinical Microbiology & Infectious Diseases / Ausgabe 5/2021
Print ISSN: 0934-9723
Elektronische ISSN: 1435-4373
DOI
https://doi.org/10.1007/s10096-020-04138-6

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