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01.05.2014 | Original Article

Additional effects of aPDT on nonsurgical periodontal treatment with doxycycline in type II diabetes: a randomized, controlled clinical trial

verfasst von: Guilherme de Oliveira Macedo, Arthur B. Novaes Jr., Sérgio L. S. Souza, Mário Taba Jr., Daniela B. Palioto, Márcio F. M. Grisi

Erschienen in: Lasers in Medical Science | Ausgabe 3/2014

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Abstract

The association of doxycycline and periodontal treatment in non-controlled diabetes mellitus (DM) has shown positive results on clinical and metabolic parameters. Antimicrobial photodynamic therapy (aPDT) is a local and painless antimicrobial treatment that can be applied in periodontal treatment without systemic risks. The aim of this study was to evaluate the potential improvement of aPDT on clinical and metabolic effects in patients with type 2 diabetes mellitus in conjunction with nonsurgical periodontal treatment plus doxycycline. Thirty patients with type 2 diabetes and diagnosis of chronic periodontitis were treated with scaling and root planning (SRP; N = 15) or SRP plus phenothiazine chloride photosensitizer-induced aPDT (SRP + aPDT, N = 15). Patients of both groups took doxycycline (100 mg/day) for 2 weeks and plaque index, bleeding on probe (BOP), probing pocket depth (PPD), suppuration, clinical attachment level (CAL), and glycated hemoglobin levels (HbA1c) were measured at baseline and 3 months after therapy. An improvement in clinical parameters such as PPD, CAL, S, and BOP between groups was observed but without statistical significance (p > 0.05). Intragroup analysis showed a significant reduction of HbA1c (8.5 ± 0.9 to 7.5 ± 0.1, p < 0.01) in the SRP + aPDT group. The differences of HbA1c between baseline and 3 months were greater for the SRP + aPDT (11.4 %) than SRP (10 %) (0.87 ± 0.9 and 0.4 ± 0.84 respectively; p < 0.05). A single application of the aPDT as an adjunct to periodontal treatment did not show additional benefits in the clinical parameters but resulted in a slight greater decrease in HbA1c.

Florida Probe, Gainesville, FL

Labtest Sistemas para Diagnóstico, Lagoa Santa, MG, Brazil

Gracey curettes, Hu-Friedy Instruments, Chicago, IL

Cavitron, Dentsply, York, PA

Vibramicina 100 mg/Pfizer, Guarulhos, SP, Brasil

Helbo Therapielaser, Helbo Photodynamic Systems, Grieskirchen, Austria

Helbo Blue, Helbo Photodynamic Systems

Helbo 3D Pocket Probe, Helbo Photodynamic Systems

SPSS, Chicago, IL

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Titel: Additional effects of aPDT on nonsurgical periodontal treatment with doxycycline in type II diabetes: a randomized, controlled clinical trial
verfasst von: Guilherme de Oliveira Macedo
Arthur B. Novaes Jr.
Sérgio L. S. Souza
Mário Taba Jr.
Daniela B. Palioto
Márcio F. M. Grisi
Publikationsdatum: 01.05.2014
Verlag: Springer London
Erschienen in: Lasers in Medical Science / Ausgabe 3/2014
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-013-1285-6

Springer Medizin

Abstract

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