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01.02.2015 | Original Article

Adjunctive effect of antimicrobial photodynamic therapy to nonsurgical periodontal treatment in smokers: a randomized clinical trial

verfasst von: Adriana C. Queiroz, Flávia Adelino Suaid, Patrícia Freitas de Andrade, Fabíola S. Oliveira, Arthur B. Novaes Jr., Mário Taba Jr., Daniela B. Palioto, Márcio F. M. Grisi, Sérgio L. S. Souza

Erschienen in: Lasers in Medical Science | Ausgabe 2/2015

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Abstract

The aim of this study was to investigate the adjunctive effect of antimicrobial photodynamic therapy (aPDT) to scaling and root planing (SRP) in smokers with chronic periodontitis. Twenty subjects had two contralateral teeth randomly assigned to receive SRP (SRP group) or SRP + a single episode of aPDT (SRP + aPDT group), with a diode laser and a phenothiazine photosensitizer. Plaque index, bleeding on probing, probing depth (PD), clinical attachment level (CAL), and gingival recession were recorded, and gingival crevicular fluid was collected for assay of IL-1β and matrix metalloproteinase (MMP)-8 levels. There was a significant PD reduction (SRP 1.81 ± 0.52 mm/SRP + aPDT 1.58 ± 1.28 mm; p < 0.001) and a significant CAL gain (SRP 1.60 ± 0.92 mm/SRP + aPDT 1.41 ± 1.58 mm; p < 0.001) for both groups. Significant differences were not observed in between-group comparisons. IL-1β level in gingival crevicular fluid was higher in SRP group after 1 week (SRP 24.65 ± 18.85 pg/μL/SRP + aPDT 34.07 ± 24.81 pg/μL; p = 0.048), and MMP-8 level was higher in SRP group after 12 weeks (SRP 303.31 ± 331.62 pg/μL/SRP + aPDT 534.23 ± 647.37 pg/μL; p = 0.024). There were no statistically significant differences in intragroup comparisons. The adjunctive effect of aPDT did not warrant improvements on clinical parameters in smokers. However, it resulted in a suppression of IL-1β and MMP-8 when compared with SRP alone.

Flemmig TF (1999) Periodontitis. Ann Periodontol Am Acad Periodontol 4(1):32–38. doi:10.1902/annals.1999.4.1.32 CrossRef

Angaji M, Gelskey S, Nogueira-Filho G, Brothwell D (2010) A systematic review of clinical efficacy of adjunctive antibiotics in the treatment of smokers with periodontitis. J Periodontol 81(11):1518–1528. doi:10.1902/jop.2010.100192 PubMedCrossRef

Soukos NS, Goodson JM (2011) Photodynamic therapy in the control of oral biofilms. Periodontol 2000 55(1):143–166. doi:10.1111/j.1600-0757.2010.00346.x PubMedCrossRef

Braham P, Herron C, Street C, Darveau R (2009) Antimicrobial photodynamic therapy may promote periodontal healing through multiple mechanisms. J Periodontol 80(11):1790–1798. doi:10.1902/jop.2009.090214 PubMedCrossRef

Fontana CR, Abernethy AD, Som S, Ruggiero K, Doucette S, Marcantonio RC, Boussios CI, Kent R, Goodson JM, Tanner AC, Soukos NS (2009) The antibacterial effect of photodynamic therapy in dental plaque-derived biofilms. J Periodontal Res 44(6):751–759. doi:10.1111/j.1600-0765.2008.01187.x PubMedCentralPubMedCrossRef

Goulart Rde C, Bolean M, Paulino Tde P, Thedei G Jr, Souza SL, Tedesco AC, Ciancaglini P (2010) Photodynamic therapy in planktonic and biofilm cultures of Aggregatibacter actinomycetemcomitans. Photomed Laser Surg 28(Suppl 1):S53–60. doi:10.1089/pho.2009.2591 PubMed

Chondros P, Nikolidakis D, Christodoulides N, Rossler R, Gutknecht N, Sculean A (2009) Photodynamic therapy as adjunct to non-surgical periodontal treatment in patients on periodontal maintenance: a randomized controlled clinical trial. Lasers Med Sci 24(5):681–688. doi:10.1007/s10103-008-0565-z PubMedCrossRef

Christodoulides N, Nikolidakis D, Chondros P, Becker J, Schwarz F, Rossler R, Sculean A (2008) Photodynamic therapy as an adjunct to non-surgical periodontal treatment: a randomized, controlled clinical trial. J Periodontol 79(9):1638–1644. doi:10.1902/jop.2008.070652 PubMedCrossRef

Polansky R, Haas M, Heschl A, Wimmer G (2009) Clinical effectiveness of photodynamic therapy in the treatment of periodontitis. J Clin Periodontol 36(7):575–580PubMedCrossRef

10.

Andersen R, Loebel N, Hammond D, Wilson M (2007) Treatment of periodontal disease by photodisinfection compared to scaling and root planing. J Clin Dent 18(2):34–38PubMed

11.

Braun A, Dehn C, Krause F, Jepsen S (2008) Short-term clinical effects of adjunctive antimicrobial photodynamic therapy in periodontal treatment: a randomized clinical trial. J Clin Periodontol 35(10):877–884. doi:10.1111/j.1600-051X.2008.01303.x PubMedCrossRef

12.

Lui J, Corbet EF, Jin L (2011) Combined photodynamic and low-level laser therapies as an adjunct to nonsurgical treatment of chronic periodontitis. J Periodontal Res 46(1):89–96. doi:10.1111/j.1600-0765.2010.01316.x PubMedCrossRef

13.

Lulic M, Leiggener Gorog I, Salvi GE, Ramseier CA, Mattheos N, Lang NP (2009) One-year outcomes of repeated adjunctive photodynamic therapy during periodontal maintenance: a proof-of-principle randomized-controlled clinical trial. J Clin Periodontol 36(8):661–666. doi:10.1111/j.1600-051X.2009.01432.x PubMedCrossRef

14.

Theodoro LH, Silva SP, Pires JR, Soares GH, Pontes AE, Zuza EP, Spolidorio DM, de Toledo BE, Garcia VG (2011) Clinical and microbiological effects of photodynamic therapy associated with nonsurgical periodontal treatment. A 6-month follow-up. Lasers Med Sci 27(4):687–93. doi:10.1007/s10103-011-0942-x PubMedCrossRef

15.

Sigusch BW, Engelbrecht M, Volpel A, Holletschke A, Pfister W, Schutze J (2010) Full-mouth antimicrobial photodynamic therapy in Fusobacterium nucleatum-infected periodontitis patients. J Periodontol 81(7):975–981. doi:10.1902/jop.2010.090246 PubMedCrossRef

16.

Azarpazhooh A, Shah PS, Tenenbaum HC, Goldberg MB (2010) The effect of photodynamic therapy for periodontitis: a systematic review and meta-analysis. J Periodontol 81(1):4–14. doi:10.1902/jop.2009.090285 PubMedCrossRef

17.

Macedo GD, Novaes AB Jr, Souza SL, Taba M Jr, Palioto DB, Grisi MF (2013) Additional effects of aPDT on nonsurgical periodontal treatment with doxycycline in type II diabetes: a randomized, controlled clinical trial. Lasers Med Sci. doi:10.1007/s10103-013-1285-6

18.

Darby IB, Hodge PJ, Riggio MP, Kinane DF (2005) Clinical and microbiological effect of scaling and root planing in smoker and non-smoker chronic and aggressive periodontitis patients. J Clin Periodontol 32(2):200–206. doi:10.1111/j.1600-051X.2005.00644.x PubMedCrossRef

19.

Preber H, Bergstrom J (1986) The effect of non-surgical treatment on periodontal pockets in smokers and non-smokers. J Clin Periodontol 13(4):319–323PubMedCrossRef

20.

Van der Velden U, Varoufaki A, Hutter JW, Xu L, Timmerman MF, Van Winkelhoff AJ, Loos BG (2003) Effect of smoking and periodontal treatment on the subgingival microflora. J Clin Periodontol 30(7):603–610PubMedCrossRef

21.

Kinane DF, Chestnutt IG (2000) Smoking and periodontal disease. Crit Rev Oral Biol Med 11(3):356–365PubMedCrossRef

22.

Preshaw PM, Taylor JJ (2011) How has research into cytokine interactions and their role in driving immune responses impacted our understanding of periodontitis? J Clin Periodontol 38(Suppl 11):60–84. doi:10.1111/j.1600-051X.2010.01671.x PubMedCrossRef

23.

Cappuyns I, Cionca N, Wick P, Giannopoulou C, Mombelli A (2011) Treatment of residual pockets with photodynamic therapy, diode laser, or deep scaling. A randomized, split-mouth controlled clinical trial. Lasers Med Sci 27(5):979–86. doi:10.1007/s10103-011-1027-6 PubMedCrossRef

24.

Ruhling A, Fanghanel J, Houshmand M, Kuhr A, Meisel P, Schwahn C, Kocher T (2010) Photodynamic therapy of persistent pockets in maintenance patients—a clinical study. Clin Oral Investig 14(6):637–644. doi:10.1007/s00784-009-0347-4 PubMedCrossRef

25.

Al-Zahrani MS, Austah ON (2011) Photodynamic therapy as an adjunctive to scaling and root planing in treatment of chronic periodontitis in smokers. Saudi Med J 32(11):1183–1188PubMed

26.

Machion L, Andia DC, Benatti BB, Carvalho MD, Nogueira-Filho GR, Casati MZ, Nociti FH Jr, Sallum EA (2004) Locally delivered doxycycline as an adjunctive therapy to scaling and root planing in the treatment of smokers: a clinical study. J Periodontol 75(3):464–469. doi:10.1902/jop.2004.75.3.464 PubMedCrossRef

27.

Palmer RM, Matthews JP, Wilson RF (1999) Non-surgical periodontal treatment with and without adjunctive metronidazole in smokers and non-smokers. J Clin Periodontol 26(3):158–163PubMedCrossRef

28.

Ryder MI, Pons B, Adams D, Beiswanger B, Blanco V, Bogle G, Donly K, Hallmon W, Hancock EB, Hanes P, Hawley C, Johnson L, Wang HL, Wolinsky L, Yukna R, Polson A, Carron G, Garrett S (1999) Effects of smoking on local delivery of controlled-release doxycycline as compared to scaling and root planing. J Clin Periodontol 26(10):683–691PubMedCrossRef

29.

Mascarenhas P, Gapski R, Al-Shammari K, Hill R, Soehren S, Fenno JC, Giannobile WV, Wang HL (2005) Clinical response of azithromycin as an adjunct to non-surgical periodontal therapy in smokers. J Periodontol 76(3):426–436. doi:10.1902/jop.2005.76.3.426 PubMedCrossRef

30.

Matarazzo F, Figueiredo LC, Cruz SE, Faveri M, Feres M (2008) Clinical and microbiological benefits of systemic metronidazole and amoxicillin in the treatment of smokers with chronic periodontitis: a randomized placebo-controlled study. J Clin Periodontol 35(10):885–896. doi:10.1111/j.1600-051X.2008.01304.x PubMedCrossRef

31.

Preshaw PM, Hefti AF, Bradshaw MH (2005) Adjunctive subantimicrobial dose doxycycline in smokers and non-smokers with chronic periodontitis. J Clin Periodontol 32(6):610–616. doi:10.1111/j.1600-051X.2005.00728.x PubMedCrossRef

32.

Ge L, Shu R, Li Y, Li C, Luo L, Song Z, Xie Y, Liu D (2011) Adjunctive effect of photodynamic therapy to scaling and root planing in the treatment of chronic periodontitis. Photomed Laser Surg 29(1):33–37. doi:10.1089/pho.2009.2727 PubMedCrossRef

33.

Yilmaz S, Kuru B, Kuru L, Noyan U, Argun D, Kadir T (2002) Effect of gallium arsenide diode laser on human periodontal disease: a microbiological and clinical study. Lasers Surg Med 30(1):60–66PubMedCrossRef

34.

Bostrom L, Linder LE, Bergstrom J (1999) Smoking and cervicular fluid levels of IL-6 and TNF-alpha in periodontal disease. J Clin Periodontol 26(6):352–357PubMedCrossRef

35.

Buduneli N, Kinane DF (2011) Host-derived diagnostic markers related to soft tissue destruction and bone degradation in periodontitis. J Clin Periodontol 38(Suppl 11):85–105. doi:10.1111/j.1600-051X.2010.01670.x PubMedCrossRef

36.

Holmlund A, Hanstrom L, Lerner UH (2004) Bone resorbing activity and cytokine levels in gingival crevicular fluid before and after treatment of periodontal disease. J Clin Periodontol 31(6):475–482. doi:10.1111/j.1600-051X.2004.00504.x PubMedCrossRef

37.

Keles GC, Cetinkaya BO, Isildak I, Koprulu H, Acikgoz G (2006) Levels of platelet activating factor in gingival crevice fluid following periodontal surgical therapy. J Periodontal Res 41(6):513–518. doi:10.1111/j.1600-0765.2006.00898.x PubMedCrossRef

38.

Thunell DH, Tymkiw KD, Johnson GK, Joly S, Burnell KK, Cavanaugh JE, Brogden KA, Guthmiller JM (2010) A multiplex immunoassay demonstrates reductions in gingival crevicular fluid cytokines following initial periodontal therapy. J Periodontal Res 45(1):148–152. doi:10.1111/j.1600-0765.2009.01204.x PubMedCrossRef

39.

Gamonal J, Acevedo A, Bascones A, Jorge O, Silva A (2000) Levels of interleukin-1 beta, -8, and −10 and RANTES in gingival crevicular fluid and cell populations in adult periodontitis patients and the effect of periodontal treatment. J Periodontol 71(10):1535–1545. doi:10.1902/jop.2000.71.10.1535 PubMedCrossRef

40.

Engebretson SP, Grbic JT, Singer R, Lamster IB (2002) GCF IL-1beta profiles in periodontal disease. J Clin Periodontol 29(1):48–53PubMedCrossRef

41.

Chen HY, Cox SW, Eley BM, Mantyla P, Ronka H, Sorsa T (2000) Matrix metalloproteinase-8 levels and elastase activities in gingival crevicular fluid from chronic adult periodontitis patients. J Clin Periodontol 27(5):366–369PubMedCrossRef

42.

Tymkiw KD, Thunell DH, Johnson GK, Joly S, Burnell KK, Cavanaugh JE, Brogden KA, Guthmiller JM (2011) Influence of smoking on gingival crevicular fluid cytokines in severe chronic periodontitis. J Clin Periodontol 38(3):219–228. doi:10.1111/j.1600-051X.2010.01684.x PubMedCentralPubMedCrossRef

43.

Kraft-Neumarker M, Lorenz K, Koch R, Hoffmann T, Mantyla P, Sorsa T, Netuschil L (2012) Full-mouth profile of active MMP-8 in periodontitis patients. J Periodontal Res 47(1):121–128. doi:10.1111/j.1600-0765.2011.01416.x PubMedCrossRef

44.

Page RC, Offenbacher S, Schroeder HE, Seymour GJ, Kornman KS (1997) Advances in the pathogenesis of periodontitis: summary of developments, clinical implications and future directions. Periodontol 2000 14:216–248PubMedCrossRef

45.

Miller CS, King CP Jr, Langub MC, Kryscio RJ, Thomas MV (2006) Salivary biomarkers of existing periodontal disease: a cross-sectional study. J Am Dent Assoc 137(3):322–329PubMedCrossRef

46.

Hernandez M, Gamonal J, Tervahartiala T, Mantyla P, Rivera O, Dezerega A, Dutzan N, Sorsa T (2010) Associations between matrix metalloproteinase-8 and −14 and myeloperoxidase in gingival crevicular fluid from subjects with progressive chronic periodontitis: a longitudinal study. J Periodontol 81(11):1644–1652. doi:10.1902/jop.2010.100196 PubMedCrossRef

47.

Reinhardt RA, Stoner JA, Golub LM, Lee HM, Nummikoski PV, Sorsa T, Payne JB (2010) Association of gingival crevicular fluid biomarkers during periodontal maintenance with subsequent progressive periodontitis. J Periodontol 81(2):251–259. doi:10.1902/jop.2009.090374 PubMedCentralPubMedCrossRef

48.

de Paula EC, de Freitas PM, Esteves-Oliveira M, Aranha AC, Ramalho KM, Simoes A, Bello-Silva MS, Tuner J (2010) Laser phototherapy in the treatment of periodontal disease. A review. Lasers Med Sci 25(6):781–792. doi:10.1007/s10103-010-0812-y CrossRef

Titel: Adjunctive effect of antimicrobial photodynamic therapy to nonsurgical periodontal treatment in smokers: a randomized clinical trial
verfasst von: Adriana C. Queiroz
Flávia Adelino Suaid
Patrícia Freitas de Andrade
Fabíola S. Oliveira
Arthur B. Novaes Jr.
Mário Taba Jr.
Daniela B. Palioto
Márcio F. M. Grisi
Sérgio L. S. Souza
Publikationsdatum: 01.02.2015
Verlag: Springer London
Erschienen in: Lasers in Medical Science / Ausgabe 2/2015
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-013-1379-1

Springer Medizin

Abstract

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