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Lasers in Medical Science

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19.08.2016 | Review Article

The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature

verfasst von: Jolien Robijns, Sandrine Censabella, Paul Bulens, Annelies Maes, Jeroen Mebis

Erschienen in: Lasers in Medical Science | Ausgabe 1/2017

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Abstract

Breast cancer is the most common cancer in women worldwide, with an incidence of 1.7 million in 2012. Breast cancer and its treatments can bring along serious side effects such as fatigue, skin toxicity, lymphedema, pain, nausea, etc. These can substantially affect the patients’ quality of life. Therefore, supportive care for breast cancer patients is an essential mainstay in the treatment. Low-level light therapy (LLLT) also named photobiomodulation therapy (PBMT) has proven its efficiency in general medicine for already more than 40 years. It is a noninvasive treatment option used to stimulate wound healing and reduce inflammation, edema, and pain. LLLT is used in different medical settings ranging from dermatology, physiotherapy, and neurology to dentistry. Since the last twenty years, LLLT is becoming a new treatment modality in supportive care for breast cancer. For this review, all existing literature concerning the use of LLLT for breast cancer was used to provide evidence in the following domains: oral mucositis (OM), radiodermatitis (RD), lymphedema, chemotherapy-induced peripheral neuropathy (CIPN), and osteonecrosis of the jaw (ONJ). The findings of this review suggest that LLLT is a promising option for the management of breast cancer treatment-related side effects. However, it still remains important to define appropriate treatment and irradiation parameters for each condition in order to ensure the effectiveness of LLLT.

Ferlay J, et al (2012) GLOBOCAN 2012 v1.1, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11. International Agency for Research on Cancer. http://globocan.iarc.fr. Accessed 26 Jul 2016

Maughan KL, Lutterbie MA, Ham PS (2010) Treatment of breast cancer. Am Fam Physician 81(11):1339–1346PubMed

Bodai BI, Tuso P (2015) Breast cancer survivorship: a comprehensive review of long-term medical issues and lifestyle recommendations. Perm J 19(2):48–79PubMedPubMedCentralCrossRef

Huang YY et al (2011) Biphasic dose response in low level light therapy—an update. Dose Response 9(4):602–618PubMedPubMedCentralCrossRef

WALT/NAALT (2014) Photobiomodulation: mainstream medicine and beyond. WALT Biennial Congress and NAALT Annual Conference, Arlington Virginia USA (September 2014)

Smith KC (2005) Laser (and LED) therapy is phototherapy. Photomed Laser Surg 23(1):78–80PubMedCrossRef

Kim WS, Calderhead RG (2011) Is light-emitting diode phototherapy (LED-LLLT) really effective? Laser Ther 20(3):205–215PubMedPubMedCentralCrossRef

Chung H et al (2012) The nuts and bolts of low-level laser (light) therapy. Ann Biomed Eng 40(2):516–533PubMedCrossRef

Oshiro T, Calderhead RG (1988) Low level laser therapy: a practical introduction. J.W. Sons, Chicester

10.

Karu TI (2008) Mitochondrial signaling in mammalian cells activated by red and near-IR radiation. Photochem Photobiol 84(5):1091–1099PubMedCrossRef

11.

Karu TI (2010) Multiple roles of cytochrome c oxidase in mammalian cells under action of red and IR-A radiation. IUBMB Life 62(8):607–610PubMedCrossRef

12.

Karu TI, Pyatibrat LV, Afanasyeva NI (2005) Cellular effects of low power laser therapy can be mediated by nitric oxide. Lasers Surg Med 36(4):307–314PubMedCrossRef

13.

Karu T, Pyatibrat L (2011) Gene expression under laser and light-emitting diodes radiation for modulation of cell adhesion: possible applications for biotechnology. IUBMB Life 63(9):747–753PubMed

14.

Bouzari N, Elsaie M, Nouri K (2011) Laser and light for wound healing stimulation. Lasers in dermatology and medicine. Springer, London

15.

Hawkins D, Abrahamse H (2006) Effect of multiple exposures of low-level laser therapy on the cellular responses of wounded human skin fibroblasts. Photomed Laser Surg 24(6):705–714PubMedCrossRef

16.

Hawkins DH, Abrahamse H (2006) The role of laser fluence in cell viability, proliferation, and membrane integrity of wounded human skin fibroblasts following helium-neon laser irradiation. Lasers Surg Med 38(1):74–83PubMedCrossRef

17.

Yu HS et al (2003) Helium-neon laser irradiation stimulates migration and proliferation in melanocytes and induces repigmentation in segmental-type vitiligo. J Invest Dermatol 120(1):56–64PubMedCrossRef

18.

Pereira AN et al (2002) Effect of low-power laser irradiation on cell growth and procollagen synthesis of cultured fibroblasts. Lasers Surg Med 31(4):263–267PubMedCrossRef

19.

Young S et al (1989) Macrophage responsiveness to light therapy. Lasers Surg Med 9(5):497–505PubMedCrossRef

20.

Posten W et al (2005) Low-level laser therapy for wound healing: mechanism and efficacy. Dermatol Surg 31(3):334–340PubMedCrossRef

21.

Lanzafame RJ et al (2007) Reciprocity of exposure time and irradiance on energy density during photoradiation on wound healing in a murine pressure ulcer model. Lasers Surg Med 39(6):534–542PubMedCrossRef

22.

Demidova-Rice TN et al (2007) Low-level light stimulates excisional wound healing in mice. Lasers Surg Med 39(9):706–715PubMedPubMedCentralCrossRef

23.

Stadler I et al (2001) 830-nm irradiation increases the wound tensile strength in a diabetic murine model. Lasers Surg Med 28(3):220–226PubMedCrossRef

24.

Schindl M et al (1999) Induction of complete wound healing in recalcitrant ulcers by low-intensity laser irradiation depends on ulcer cause and size. Photodermatol Photoimmunol Photomed 15(1):18–21PubMedCrossRef

25.

Smoot B et al (2010) Upper extremity impairments in women with or without lymphedema following breast cancer treatment. J Cancer Surviv 4(2):167–178PubMedPubMedCentralCrossRef

26.

Oberoi S et al (2014) Effect of prophylactic low level laser therapy on oral mucositis: a systematic review and meta-analysis. PLoS One 9(9):e107418PubMedPubMedCentralCrossRef

27.

Hayes SC et al (2012) Upper-body morbidity after breast cancer: incidence and evidence for evaluation, prevention, and management within a prospective surveillance model of care. Cancer 118(8 Suppl):2237–2249PubMedCrossRef

28.

DiSipio T et al (2013) Incidence of unilateral arm lymphoedema after breast cancer: a systematic review and meta-analysis. Lancet Oncol 14(6):500–515PubMedCrossRef

29.

Ridner SH (2005) Quality of life and a symptom cluster associated with breast cancer treatment-related lymphedema. Support Care Cancer 13(11):904–911PubMedCrossRef

30.

Hwang JM et al (2013) Long-term effects of complex decongestive therapy in breast cancer patients with arm lymphedema after axillary dissection. Ann Rehabil Med 37(5):690–697PubMedPubMedCentralCrossRef

31.

Hwang KH et al (2013) Clinical effectiveness of complex decongestive physiotherapy for malignant lymphedema: a pilot study. Ann Rehabil Med 37(3):396–402PubMedPubMedCentralCrossRef

32.

Carati CJ et al (2003) Treatment of postmastectomy lymphedema with low-level laser therapy: a double blind, placebo-controlled trial. Cancer 98(6):1114–1122PubMedCrossRef

33.

Ridner SH et al (2013) A pilot randomized trial evaluating low-level laser therapy as an alternative treatment to manual lymphatic drainage for breast cancer-related lymphedema. Oncol Nurs Forum 40(4):383–393PubMedCrossRef

34.

Dirican A et al (2011) The short-term effects of low-level laser therapy in the management of breast-cancer-related lymphedema. Support Care Cancer 19(5):685–690PubMedCrossRef

35.

E Lima MT et al (2014) Low-level laser therapy in secondary lymphedema after breast cancer: systematic review. Lasers Med Sci 29(3):1289–1295

36.

Smoot B et al (2014) Effect of low-level laser therapy on pain and swelling in women with breast cancer-related lymphedema: a systematic review and meta-analysis. J Cancer Surviv 9(2):287–304

37.

Peterson DE et al (2011) Management of oral and gastrointestinal mucositis: ESMO clinical practice guidelines. Ann Oncol 22(Suppl 6):vi78–vi84PubMedPubMedCentral

38.

Lalla RV et al (2014) MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer 120(10):1453–1461PubMedPubMedCentralCrossRef

39.

Migliorati C et al (2013) Systematic review of laser and other light therapy for the management of oral mucositis in cancer patients. Support Care Cancer 21(1):333–341PubMedCrossRef

40.

Bensinger W et al (2008) NCCN Task Force Report. Prevention and management of mucositis in cancer care. J Natl Compr Canc Netw 6(Suppl 1):S1–S21, quiz S22–4PubMed

41.

Kuhn A et al (2007) Low-level infrared laser therapy for chemo- or radiation-induced oral mucositis: a randomized placebo-controlled study. J Oral Laser Appl 7:175–181

42.

Genot-Klastersky MT et al (2008) The use of low-energy laser (LEL) for the prevention of chemotherapy- and/or radiotherapy-induced oral mucositis in cancer patients: results from two prospective studies. Support Care Cancer 16(12):1381–1387PubMedCrossRef

43.

Pires-Santos G et al (2012) Use of laser photobiomodulation in the evolution of oral mucositis associated with CMF chemotherapy protocol in patients with breast cancer—case report. Med Oral Patol Oral Cir Bucal 17(Supplement1):S252

44.

Arbabi-Kalati F, Arbabi-Kalati F, Moridi T (2013) Evaluation of the effect of low level laser on prevention of chemotherapy-induced mucositis. Acta Med Iran 51(3):157–162PubMed

45.

Mebis J, et al (2015) Evaluation of the effect of low level laser therapy on oral mucositis in breast cancer patients: a retrospective analysis. Cancer Res 75(9 Suppl): Abstract nr P5-15-05

46.

Cox J, Ang K (2010) Radiation oncology: rationale, technique, results, 9th edn. Mosby Elsevier, Philadelphia

47.

Cox JD, Stetz J, Pajak TF (1995) Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys 31(5):1341–1346PubMedCrossRef

48.

Twardella D et al (2003) Personal characteristics, therapy modalities and individual DNA repair capacity as predictive factors of acute skin toxicity in an unselected cohort of breast cancer patients receiving radiotherapy. Radiother Oncol 69(2):145–153PubMedCrossRef

49.

Wells M, MacBride S (2003) Radiation skin reactions. Supportive Care in Radiotherapy. Churchill Livingstone, Edinburgh

50.

Hymes SR, Strom EA, Fife C (2006) Radiation dermatitis: clinical presentation, pathophysiology, and treatment 2006. J Am Acad Dermatol 54(1):28–46PubMedCrossRef

51.

Mendelsohn FA et al (2002) Wound care after radiation therapy. Adv Skin Wound Care 15(5):216–224PubMedCrossRef

52.

Wong RK et al (2013) Clinical practice guidelines for the prevention and treatment of acute and late radiation reactions from the MASCC Skin Toxicity Study Group. Support Care Cancer 21(10):2933–2948PubMedCrossRef

53.

Schindl A et al (1999) Increased dermal angiogenesis after low-intensity laser therapy for a chronic radiation ulcer determined by a video measuring system. J Am Acad Dermatol 40(3):481–484PubMedCrossRef

54.

Schindl A et al (1999) Diabetic neuropathic foot ulcer: successful treatment by low-intensity laser therapy. Dermatology 198(3):314–316PubMedCrossRef

55.

DeLand MM et al (2007) Treatment of radiation-induced dermatitis with light-emitting diode (LED) photomodulation. Lasers Surg Med 39(2):164–168PubMedCrossRef

56.

Fife D et al (2010) A randomized, controlled, double-blind study of light emitting diode photomodulation for the prevention of radiation dermatitis in patients with breast cancer. Dermatol Surg 36(12):1921–1927PubMedCrossRef

57.

Censabella S et al (2016) Photobiomodulation for the management of radiation dermatitis: the DERMIS trial, a pilot study of MLS® laser therapy in breast cancer patients. Support Care Cancer 24(9):3925–3933

58.

Costa TC et al (2015) Chemotherapy-induced peripheral neuropathies: an integrative review of the literature. Rev Esc Enferm USP 49(2):335–345PubMedCrossRef

59.

De Iuliis F et al (2015) Taxane induced neuropathy in patients affected by breast cancer: literature review. Crit Rev Oncol Hematol 96(1):34–45

60.

Pachman DR et al (2014) Management options for established chemotherapy-induced peripheral neuropathy. Support Care Cancer 22(8):2281–2295PubMedCrossRef

61.

Yamada K, Kaise H, Ogata A (2010) Low-level laser therapy for symptoms induced by breast cancer treatments. 2010 ASCO Breast Cancer Symposium

62.

Hsieh YL, Fan YC, Yang CC (2015) Low-level laser therapy alleviates mechanical and cold allodynia induced by oxaliplatin administration in rats. Support Care Cancer 24(1):233–2342

63.

Rogers MJ et al (2000) Cellular and molecular mechanisms of action of bisphosphonates. Cancer 88(12 Suppl):2961–2978PubMedCrossRef

64.

Brown-Glaberman U, Stopeck AT (2012) Role of denosumab in the management of skeletal complications in patients with bone metastases from solid tumors. Biologics 6:89–99PubMedPubMedCentral

65.

Pavlakis N, Schmidt R, Stockler M (2005) Bisphosphonates for breast cancer. Cochrane Database Syst Rev 3:CD003474

66.

Paulo S et al (2014) Bisphosphonate-related osteonecrosis of the jaw: specificities. Oncol Rev 8(2):254PubMedPubMedCentralCrossRef

67.

Ruggiero SL et al (2014) American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw—2014 update. J Oral Maxillofac Surg 72(10):1938–1956PubMedCrossRef

68.

Khosla S et al (2007) Bisphosphonate-associated osteonecrosis of the jaw: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res 22(10):1479–1491PubMedCrossRef

69.

Khan AA et al (2015) Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus. J Bone Miner Res 30(1):3–23PubMedCrossRef

70.

Carroll JD et al (2014) Developments in low level light therapy (LLLT) for dentistry. Dent Mater 30(5):465–475PubMedCrossRef

71.

Kathuria V, Dhillon JK, Kalra G (2015) Low level laser therapy: a panacea for oral maladies. Laser Ther 24(3):215–223PubMedPubMedCentralCrossRef

72.

Aras MH et al (2015) Effects of low-level laser therapy on osteoblastic bone formation and relapse in an experimental rapid maxillary expansion model. Niger J Clin Pract 18(5):607–611PubMedCrossRef

73.

Gomes FV et al (2015) Low-level laser therapy improves peri-implant bone formation: resonance frequency, electron microscopy, and stereology findings in a rabbit model. Int J Oral Maxillofac Surg 44(2):245–251PubMedCrossRef

74.

Scalize PH et al (2015) Low-level laser therapy improves bone formation: stereology findings for osteoporosis in rat model. Lasers Med Sci 30(5):1599–1607PubMedCrossRef

75.

Abd-Elaal AZ et al (2015) Evaluation of the effect of low-level diode laser therapy applied during the bone consolidation period following mandibular distraction osteogenesis in the human. Int J Oral Maxillofac Surg 44(8):989–997PubMedCrossRef

76.

Sella VR et al (2015) Effect of low-level laser therapy on bone repair: a randomized controlled experimental study. Lasers Med Sci 30(3):1061–1068PubMedCrossRef

77.

Angiero F et al (2009) Osteonecrosis of the jaws caused by bisphosphonates: evaluation of a new therapeutic approach using the Er:YAG laser. Lasers Med Sci 24(6):849–856PubMedCrossRef

78.

Scoletta M et al (2010) Effect of low-level laser irradiation on bisphosphonate-induced osteonecrosis of the jaws: preliminary results of a prospective study. Photomed Laser Surg 28(2):179–184PubMedCrossRef

79.

Romeo U et al (2011) Observation of pain control in patients with bisphosphonate-induced osteonecrosis using low level laser therapy: preliminary results. Photomed Laser Surg 29(7):447–452PubMedCrossRef

80.

Vescovi P et al (2012) Surgical approach and laser applications in BRONJ osteoporotic and cancer patients. J Osteoporos 2012:585434PubMedPubMedCentralCrossRef

81.

Martins MA et al (2012) Association of laser phototherapy with PRP improves healing of bisphosphonate-related osteonecrosis of the jaws in cancer patients: a preliminary study. Oral Oncol 48(1):79–84PubMedCrossRef

82.

Altay MA et al (2014) Low-level laser therapy supported surgical treatment of bisphosphonate related osteonecrosis of jaws: a retrospective analysis of 11 cases. Photomed Laser Surg 32(8):468–475PubMedCrossRef

83.

Avci P et al (2013) Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring. Semin Cutan Med Surg 32(1):41–52PubMedPubMedCentral

84.

Piller NB, Thelander A (1998) Treatment of chronic postmastectomy lymphedema with low level laser therapy: a 2.5 year follow-up. Lymphology 31(2):74–86PubMed

85.

Kaviani A et al (2006) Low-level laser therapy in management of postmastectomy lymphedema. Lasers Med Sci 21(2):90–94PubMedCrossRef

86.

Maiya A, Olivia E, Dibya A (2008) Effect of low energy laser therapy in the management of post-mastectomy lymphoedema. Physiother Sing 11:2–5

87.

Kozanoglu E et al (2009) Efficacy of pneumatic compression and low-level laser therapy in the treatment of postmastectomy lymphoedema: a randomized controlled trial. Clin Rehabil 23(2):117–124PubMedCrossRef

88.

Lau RW, Cheing GL (2009) Managing postmastectomy lymphedema with low-level laser therapy. Photomed Laser Surg 27(5):763–769PubMedCrossRef

89.

Ahmed Omar MT, Abd-El-Gayed Ebid A, El Morsy AM (2011) Treatment of post-mastectomy lymphedema with laser therapy: double blind placebo control randomized study. J Surg Res 165(1):82–90PubMedCrossRef

Titel: The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature
verfasst von: Jolien Robijns
Sandrine Censabella
Paul Bulens
Annelies Maes
Jeroen Mebis
Publikationsdatum: 19.08.2016
Verlag: Springer London
Erschienen in: Lasers in Medical Science / Ausgabe 1/2017
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-016-2056-y

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature

Abstract

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

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