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Erschienen in: Lasers in Medical Science 3/2017

11.01.2017 | Original Article

Efficacy of pulsed Nd:YAG laser in the treatment of patients with knee osteoarthritis: a randomized controlled trial

verfasst von: Mohamed Salaheldien Mohamed Alayat, Tarek Helmy Ahmed Aly, Aly Elsayed Mohamed Elsayed, Ammar Suliman Mohamed Fadil

Erschienen in: Lasers in Medical Science | Ausgabe 3/2017

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Abstract

The purpose of this study was to investigate the effects of pulsed Nd:YAG laser plus glucosamine/chondroitin sulfate (GCS) in patients with knee osteoarthritis (KOA) by examining changes in pain and knee function, as well as synovial thickness (ST) and femoral cartilage thickness (FCT). Sixty-seven male patients participated, with a mean (SD) age of 53.85 (4.39) years, weight of 84.01 (4.70) kg, height of 171.51 (3.96) cm, and BMI of 28.56 (1.22). Group 1 was treated with high-intensity laser therapy (HILT), GCS, and exercises (HILT + GCS + EX). Group 2 was treated with GCS plus exercises (GCS + EX), and group 3 received placebo laser plus exercises (PL + EX). The outcomes measured were pain level and functional disability using the visual analog scale (VAS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), respectively. ST and FCT were measured by ultrasound examination. Statistical analyses were performed to compare differences between baseline and after 6 weeks of treatment and then after 3 months of follow-up. Statistical significance was set at p < 0.05. VAS and WOMAC were significantly decreased in all groups after 6 weeks, with nonsignificant differences between 6 weeks and 3 months of follow-up. ST was significantly decreased in the HILT + GCS + EX group posttreatment, with nonsignificant decreases in the GCS + EX and PL + EX groups, as well as nonsignificant differences to FCT in all groups. Overall, pulsed Nd:YAG laser combined with GCS and exercises was more effective than GCS + EX and exercises alone in the treatment of KOA patients.
Literatur
1.
Zurück zum Zitat Arden N, Blanco F, Cooper C, Guermazi A, Hayashi D, Hunter D et al (2014) Atlas of osteoarthriti. Springer, LondonCrossRef Arden N, Blanco F, Cooper C, Guermazi A, Hayashi D, Hunter D et al (2014) Atlas of osteoarthriti. Springer, LondonCrossRef
2.
Zurück zum Zitat Felson DT, Lawrence RC, Dieppe PA, Hirsch R, Helmick CG, Jordan JM et al (2000) Osteoarthritis: new insights. Part 1: the disease and its risk factors. Ann Intern Med 133(8):635–646CrossRefPubMed Felson DT, Lawrence RC, Dieppe PA, Hirsch R, Helmick CG, Jordan JM et al (2000) Osteoarthritis: new insights. Part 1: the disease and its risk factors. Ann Intern Med 133(8):635–646CrossRefPubMed
3.
Zurück zum Zitat Steultjens MP, Dekker J, van Baar ME, Oostendorp RA, Bijlsma JW (2000) Range of joint motion and disability in patients with osteoarthritis of the knee or hip. Rheumatology (Oxford) 39(9):955–961CrossRef Steultjens MP, Dekker J, van Baar ME, Oostendorp RA, Bijlsma JW (2000) Range of joint motion and disability in patients with osteoarthritis of the knee or hip. Rheumatology (Oxford) 39(9):955–961CrossRef
4.
Zurück zum Zitat Kumm J, Tamm A, Lintrop M (2009) Association between ultrasonographic findings and bone/cartilage biomarkers in patients with early-stage knee osteoarthritis. Calcif Tissue Int 85(6):514–522CrossRefPubMed Kumm J, Tamm A, Lintrop M (2009) Association between ultrasonographic findings and bone/cartilage biomarkers in patients with early-stage knee osteoarthritis. Calcif Tissue Int 85(6):514–522CrossRefPubMed
5.
Zurück zum Zitat Cowan SM, Bennell KL, Hodges PW, Crossley KM, McConnell J (2001) Delayed onset of electromyographic activity of vastus medialis obliquus relative to vastus lateralis in subjects with patellofemoral pain syndrome. Arch Phys Med Rehabil 82(2):183–189CrossRefPubMed Cowan SM, Bennell KL, Hodges PW, Crossley KM, McConnell J (2001) Delayed onset of electromyographic activity of vastus medialis obliquus relative to vastus lateralis in subjects with patellofemoral pain syndrome. Arch Phys Med Rehabil 82(2):183–189CrossRefPubMed
6.
Zurück zum Zitat Rogers MW, Wilder FV (2008) The association of BMI and knee pain among persons with radiographic knee osteoarthritis: a cross-sectional study. BMC Musculoskelet Disord 9:163CrossRefPubMedPubMedCentral Rogers MW, Wilder FV (2008) The association of BMI and knee pain among persons with radiographic knee osteoarthritis: a cross-sectional study. BMC Musculoskelet Disord 9:163CrossRefPubMedPubMedCentral
7.
Zurück zum Zitat Yildiz SK, Ozkan FU, Aktas I, Silte AD, Kaysin MY, Badur NB (2015) The effectiveness of ultrasound treatment for the management of knee osteoarthritis: a randomized, placebo-controlled, double-blind study. Turk J Med Sci 45(6):1187–1191CrossRefPubMed Yildiz SK, Ozkan FU, Aktas I, Silte AD, Kaysin MY, Badur NB (2015) The effectiveness of ultrasound treatment for the management of knee osteoarthritis: a randomized, placebo-controlled, double-blind study. Turk J Med Sci 45(6):1187–1191CrossRefPubMed
8.
Zurück zum Zitat Qingguang Z, Min F, Li G, Shuyun J, Wuquan S, Jianhua L et al (2015) Gait analysis of patients with knee osteoarthritis before and after Chinese massage treatment. J Tradit Chin Med 35(4):411–416CrossRefPubMed Qingguang Z, Min F, Li G, Shuyun J, Wuquan S, Jianhua L et al (2015) Gait analysis of patients with knee osteoarthritis before and after Chinese massage treatment. J Tradit Chin Med 35(4):411–416CrossRefPubMed
9.
Zurück zum Zitat Creamer P, Lethbridge-Cejku M, Hochberg MC (2000) Factors associated with functional impairment in symptomatic knee osteoarthritis. Rheumatology (Oxford) 39(5):490–496CrossRef Creamer P, Lethbridge-Cejku M, Hochberg MC (2000) Factors associated with functional impairment in symptomatic knee osteoarthritis. Rheumatology (Oxford) 39(5):490–496CrossRef
10.
Zurück zum Zitat Al-Arfaj A, Al-Boukai AA (2002) Prevalence of radiographic knee osteoarthritis in Saudi Arabia. Clin Rheumatol 21(2):142–145CrossRefPubMed Al-Arfaj A, Al-Boukai AA (2002) Prevalence of radiographic knee osteoarthritis in Saudi Arabia. Clin Rheumatol 21(2):142–145CrossRefPubMed
11.
Zurück zum Zitat Jamtvedt G, Dahm KT, Holm I, Odegaard-Jensen J, Flottorp S (2010) Choice of treatment modalities was not influenced by pain, severity or co-morbidity in patients with knee osteoarthritis. Physiother Res Int 15(1):16–23PubMed Jamtvedt G, Dahm KT, Holm I, Odegaard-Jensen J, Flottorp S (2010) Choice of treatment modalities was not influenced by pain, severity or co-morbidity in patients with knee osteoarthritis. Physiother Res Int 15(1):16–23PubMed
12.
Zurück zum Zitat Kon E, Filardo G, Drobnic M, Madry H, Jelic M, van Dijk N et al (2012) Non-surgical management of early knee osteoarthritis. Knee Surg Sports Traumatol Arthrosc 20(3):436–449CrossRefPubMed Kon E, Filardo G, Drobnic M, Madry H, Jelic M, van Dijk N et al (2012) Non-surgical management of early knee osteoarthritis. Knee Surg Sports Traumatol Arthrosc 20(3):436–449CrossRefPubMed
13.
Zurück zum Zitat Jan MH, Chai HM, Wang CL, Lin YF, Tsai LY (2006) Effects of repetitive shortwave diathermy for reducing synovitis in patients with knee osteoarthritis: an ultrasonographic study. Phys Ther 86(2):236–244PubMed Jan MH, Chai HM, Wang CL, Lin YF, Tsai LY (2006) Effects of repetitive shortwave diathermy for reducing synovitis in patients with knee osteoarthritis: an ultrasonographic study. Phys Ther 86(2):236–244PubMed
14.
Zurück zum Zitat Yildiriim MA, Ucar D, Ones K (2015) Comparison of therapeutic duration of therapeutic ultrasound in patients with knee osteoarthritis. J Phys Ther Sci 27(12):3667–3670CrossRefPubMedPubMedCentral Yildiriim MA, Ucar D, Ones K (2015) Comparison of therapeutic duration of therapeutic ultrasound in patients with knee osteoarthritis. J Phys Ther Sci 27(12):3667–3670CrossRefPubMedPubMedCentral
15.
Zurück zum Zitat de Oliveira Melo M, Pompeo KD, Baroni BM, Vaz MA (2016) Effects of neuromuscular electrical stimulation and low-level laser therapy on neuromuscular parameters and health status in elderly women with knee osteoarthritis: a randomized trial. J Rehabil Med 48(3):293–299CrossRefPubMed de Oliveira Melo M, Pompeo KD, Baroni BM, Vaz MA (2016) Effects of neuromuscular electrical stimulation and low-level laser therapy on neuromuscular parameters and health status in elderly women with knee osteoarthritis: a randomized trial. J Rehabil Med 48(3):293–299CrossRefPubMed
16.
Zurück zum Zitat Ip D, Fu NY (2015) Can combined use of low-level lasers and hyaluronic acid injections prolong the longevity of degenerative knee joints? Clin Interv Aging 10:1255–1258CrossRefPubMedPubMedCentral Ip D, Fu NY (2015) Can combined use of low-level lasers and hyaluronic acid injections prolong the longevity of degenerative knee joints? Clin Interv Aging 10:1255–1258CrossRefPubMedPubMedCentral
17.
Zurück zum Zitat Alghadir A, Omar MT, Al-Askar AB, Al-Muteri NK (2014) Effect of low-level laser therapy in patients with chronic knee osteoarthritis: a single-blinded randomized clinical study. Lasers Med Sci 29(2):749–755CrossRefPubMed Alghadir A, Omar MT, Al-Askar AB, Al-Muteri NK (2014) Effect of low-level laser therapy in patients with chronic knee osteoarthritis: a single-blinded randomized clinical study. Lasers Med Sci 29(2):749–755CrossRefPubMed
18.
Zurück zum Zitat Yurtkuran M, Alp A, Konur S, Ozcakir S, Bingol U (2007) Laser acupuncture in knee osteoarthritis: a double-blind, randomized controlled study. Photomed Laser Surg 25(1):14–20CrossRefPubMed Yurtkuran M, Alp A, Konur S, Ozcakir S, Bingol U (2007) Laser acupuncture in knee osteoarthritis: a double-blind, randomized controlled study. Photomed Laser Surg 25(1):14–20CrossRefPubMed
19.
Zurück zum Zitat Hegedus B, Viharos L, Gervain M, Galfi M (2009) The effect of low-level laser in knee osteoarthritis: a double-blind, randomized, placebo-controlled trial. Photomed Laser Surg 27(4):577–584CrossRefPubMedPubMedCentral Hegedus B, Viharos L, Gervain M, Galfi M (2009) The effect of low-level laser in knee osteoarthritis: a double-blind, randomized, placebo-controlled trial. Photomed Laser Surg 27(4):577–584CrossRefPubMedPubMedCentral
20.
Zurück zum Zitat Al Rashoud AS, Abboud RJ, Wang W, Wigderowitz C (2014) Efficacy of low-level laser therapy applied at acupuncture points in knee osteoarthritis: a randomised double-blind comparative trial. Physiotherapy 100(3):242–248CrossRefPubMed Al Rashoud AS, Abboud RJ, Wang W, Wigderowitz C (2014) Efficacy of low-level laser therapy applied at acupuncture points in knee osteoarthritis: a randomised double-blind comparative trial. Physiotherapy 100(3):242–248CrossRefPubMed
21.
Zurück zum Zitat Rubio CR, Cremonezzi D, Moya M, Soriano F, Palma J, Campana V (2010) Helium-neon laser reduces the inflammatory process of arthritis. Photomed Laser Surg 28(1):125–129CrossRefPubMed Rubio CR, Cremonezzi D, Moya M, Soriano F, Palma J, Campana V (2010) Helium-neon laser reduces the inflammatory process of arthritis. Photomed Laser Surg 28(1):125–129CrossRefPubMed
22.
Zurück zum Zitat Sakurai Y, Yamaguchi M, Abiko Y (2000) Inhibitory effect of low-level laser irradiation on LPS-stimulated prostaglandin E2 production and cyclooxygenase-2 in human gingival fibroblasts. Eur J Oral Sci 108(1):29–34CrossRefPubMed Sakurai Y, Yamaguchi M, Abiko Y (2000) Inhibitory effect of low-level laser irradiation on LPS-stimulated prostaglandin E2 production and cyclooxygenase-2 in human gingival fibroblasts. Eur J Oral Sci 108(1):29–34CrossRefPubMed
23.
Zurück zum Zitat Gur A, Cosut A, Sarac AJ, Cevik R, Nas K, Uyar A (2003) Efficacy of different therapy regimes of low-power laser in painful osteoarthritis of the knee: a double-blind and randomized-controlled trial. Lasers Surg Med 33(5):330–338CrossRefPubMed Gur A, Cosut A, Sarac AJ, Cevik R, Nas K, Uyar A (2003) Efficacy of different therapy regimes of low-power laser in painful osteoarthritis of the knee: a double-blind and randomized-controlled trial. Lasers Surg Med 33(5):330–338CrossRefPubMed
24.
Zurück zum Zitat Tascioglu F, Armagan O, Tabak Y, Corapci I, Oner C (2004) Low power laser treatment in patients with knee osteoarthritis. Swiss Med Wkly 134(17–18):254–258PubMed Tascioglu F, Armagan O, Tabak Y, Corapci I, Oner C (2004) Low power laser treatment in patients with knee osteoarthritis. Swiss Med Wkly 134(17–18):254–258PubMed
26.
Zurück zum Zitat Alayat MS, Atya AM, Ali MM, Shosha TM (2014) Long-term effect of high-intensity laser therapy in the treatment of patients with chronic low back pain: a randomized blinded placebo-controlled trial. Lasers Med Sci 29(3):1065–1073CrossRefPubMed Alayat MS, Atya AM, Ali MM, Shosha TM (2014) Long-term effect of high-intensity laser therapy in the treatment of patients with chronic low back pain: a randomized blinded placebo-controlled trial. Lasers Med Sci 29(3):1065–1073CrossRefPubMed
27.
Zurück zum Zitat Alayat MS, Mohamed AA, Helal OF, Khaled OA (2016) Efficacy of high-intensity laser therapy in the treatment of chronic neck pain: a randomized double-blind placebo-control trial. Lasers Med Sci 31(4):687–694CrossRefPubMed Alayat MS, Mohamed AA, Helal OF, Khaled OA (2016) Efficacy of high-intensity laser therapy in the treatment of chronic neck pain: a randomized double-blind placebo-control trial. Lasers Med Sci 31(4):687–694CrossRefPubMed
28.
Zurück zum Zitat Stiglic-Rogoznica N, Stamenkovic D, Frlan-Vrgoc L, Avancini-Dobrovic V, Vrbanic TS (2011) Analgesic effect of high intensity laser therapy in knee osteoarthritis. Coll Antropol 35(Suppl 2):183–185PubMed Stiglic-Rogoznica N, Stamenkovic D, Frlan-Vrgoc L, Avancini-Dobrovic V, Vrbanic TS (2011) Analgesic effect of high intensity laser therapy in knee osteoarthritis. Coll Antropol 35(Suppl 2):183–185PubMed
29.
Zurück zum Zitat Kheshie AR, Alayat MS, Ali MM (2014) High-intensity versus low-level laser therapy in the treatment of patients with knee osteoarthritis: a randomized controlled trial. Lasers Med Sci 29:1371–1376CrossRefPubMed Kheshie AR, Alayat MS, Ali MM (2014) High-intensity versus low-level laser therapy in the treatment of patients with knee osteoarthritis: a randomized controlled trial. Lasers Med Sci 29:1371–1376CrossRefPubMed
30.
Zurück zum Zitat Naredo E, Cabero F, Palop MJ, Collado P, Cruz A, Crespo M (2005) Ultrasonographic findings in knee osteoarthritis: a comparative study with clinical and radiographic assessment. Osteoarthritis Cartilage 13(7):568–574CrossRefPubMed Naredo E, Cabero F, Palop MJ, Collado P, Cruz A, Crespo M (2005) Ultrasonographic findings in knee osteoarthritis: a comparative study with clinical and radiographic assessment. Osteoarthritis Cartilage 13(7):568–574CrossRefPubMed
31.
Zurück zum Zitat Naredo E, Acebes C, Moller I, Canillas F, de Agustin JJ, de Miguel E et al (2009) Ultrasound validity in the measurement of knee cartilage thickness. Ann Rheum Dis 68(8):1322–1327CrossRefPubMed Naredo E, Acebes C, Moller I, Canillas F, de Agustin JJ, de Miguel E et al (2009) Ultrasound validity in the measurement of knee cartilage thickness. Ann Rheum Dis 68(8):1322–1327CrossRefPubMed
32.
Zurück zum Zitat Maly MR, Costigan PA, Olney SJ (2006) Determinants of self-report outcome measures in people with knee osteoarthritis. Arch Phys Med Rehabil 87(1):96–104CrossRefPubMed Maly MR, Costigan PA, Olney SJ (2006) Determinants of self-report outcome measures in people with knee osteoarthritis. Arch Phys Med Rehabil 87(1):96–104CrossRefPubMed
33.
Zurück zum Zitat Revill SI, Robinson JO, Rosen M, Hogg MI (1976) The reliability of a linear analogue for evaluating pain. Anaesthesia 31(9):1191–1198CrossRefPubMed Revill SI, Robinson JO, Rosen M, Hogg MI (1976) The reliability of a linear analogue for evaluating pain. Anaesthesia 31(9):1191–1198CrossRefPubMed
34.
Zurück zum Zitat Faik A, Benbouazza K, Amine B, Maaroufi H, Bahiri R, Lazrak N et al (2008) Translation and validation of Moroccan Western Ontario and McMaster Universities (WOMAC) osteoarthritis index in knee osteoarthritis. Rheumatol Int 28(7):677–683CrossRefPubMed Faik A, Benbouazza K, Amine B, Maaroufi H, Bahiri R, Lazrak N et al (2008) Translation and validation of Moroccan Western Ontario and McMaster Universities (WOMAC) osteoarthritis index in knee osteoarthritis. Rheumatol Int 28(7):677–683CrossRefPubMed
35.
Zurück zum Zitat Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW (1988) Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol 15(12):1833–1840PubMed Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW (1988) Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol 15(12):1833–1840PubMed
36.
Zurück zum Zitat Yoon CH, Kim HS, Ju JH, Jee WH, Park SH, Kim HY (2008) Validity of the sonographic longitudinal sagittal image for assessment of the cartilage thickness in the knee osteoarthritis. Clin Rheumatol 27(12):1507–1516CrossRefPubMed Yoon CH, Kim HS, Ju JH, Jee WH, Park SH, Kim HY (2008) Validity of the sonographic longitudinal sagittal image for assessment of the cartilage thickness in the knee osteoarthritis. Clin Rheumatol 27(12):1507–1516CrossRefPubMed
37.
Zurück zum Zitat Hochman B, Pinfildi CE, Nishioka MA, Furtado F, Bonatti S, Monteiro PK et al (2014) Low-level laser therapy and light-emitting diode effects in the secretion of neuropeptides SP and CGRP in rat skin. Lasers Med Sci 29(3):1203–1208CrossRefPubMed Hochman B, Pinfildi CE, Nishioka MA, Furtado F, Bonatti S, Monteiro PK et al (2014) Low-level laser therapy and light-emitting diode effects in the secretion of neuropeptides SP and CGRP in rat skin. Lasers Med Sci 29(3):1203–1208CrossRefPubMed
38.
Zurück zum Zitat Hsieh YL, Hong CZ, Chou LW, Yang SA, Yang CC (2015) Fluence-dependent effects of low-level laser therapy in myofascial trigger spots on modulation of biochemicals associated with pain in a rabbit model. Lasers Med Sci 30(1):209–216CrossRefPubMed Hsieh YL, Hong CZ, Chou LW, Yang SA, Yang CC (2015) Fluence-dependent effects of low-level laser therapy in myofascial trigger spots on modulation of biochemicals associated with pain in a rabbit model. Lasers Med Sci 30(1):209–216CrossRefPubMed
39.
Zurück zum Zitat King CE, Clelland JA, Knowles CJ, Jackson JR (1990) Effect of helium-neon laser auriculotherapy on experimental pain threshold. Phys Ther 70(1):24–30CrossRefPubMed King CE, Clelland JA, Knowles CJ, Jackson JR (1990) Effect of helium-neon laser auriculotherapy on experimental pain threshold. Phys Ther 70(1):24–30CrossRefPubMed
40.
Zurück zum Zitat Chow R, Armati P, Laakso EL, Bjordal JM, Baxter GD (2011) Inhibitory effects of laser irradiation on peripheral mammalian nerves and relevance to analgesic effects: a systematic review. Photomed Laser Surg 29(6):365–381CrossRefPubMed Chow R, Armati P, Laakso EL, Bjordal JM, Baxter GD (2011) Inhibitory effects of laser irradiation on peripheral mammalian nerves and relevance to analgesic effects: a systematic review. Photomed Laser Surg 29(6):365–381CrossRefPubMed
41.
Zurück zum Zitat Hagiwara S, Iwasaka H, Hasegawa A, Noguchi T (2008) Pre-irradiation of blood by gallium aluminum arsenide (830 nm) low-level laser enhances peripheral endogenous opioid analgesia in rats. Anesth Analg 107(3):1058–1063CrossRefPubMed Hagiwara S, Iwasaka H, Hasegawa A, Noguchi T (2008) Pre-irradiation of blood by gallium aluminum arsenide (830 nm) low-level laser enhances peripheral endogenous opioid analgesia in rats. Anesth Analg 107(3):1058–1063CrossRefPubMed
42.
Zurück zum Zitat Samoilova KA, Zhevago NA, Petrishchev NN, Zimin AA (2008) Role of nitric oxide in the visible light-induced rapid increase of human skin microcirculation at the local and systemic levels: II. Healthy volunteers. Photomed Laser Surg 26(5):443–449CrossRefPubMed Samoilova KA, Zhevago NA, Petrishchev NN, Zimin AA (2008) Role of nitric oxide in the visible light-induced rapid increase of human skin microcirculation at the local and systemic levels: II. Healthy volunteers. Photomed Laser Surg 26(5):443–449CrossRefPubMed
43.
Zurück zum Zitat Moriyama Y, Nguyen J, Akens M, Moriyama EH, Lilge L (2009) In vivo effects of low level laser therapy on inducible nitric oxide synthase. Lasers Surg Med 41(3):227–231CrossRefPubMed Moriyama Y, Nguyen J, Akens M, Moriyama EH, Lilge L (2009) In vivo effects of low level laser therapy on inducible nitric oxide synthase. Lasers Surg Med 41(3):227–231CrossRefPubMed
44.
Zurück zum Zitat Wang P, Liu C, Yang X, Zhou Y, Wei X, Ji Q et al (2014) Effects of low-level laser therapy on joint pain, synovitis, anabolic, and catabolic factors in a progressive osteoarthritis rabbit model. Lasers Med Sci 29(6):1875–1885CrossRefPubMed Wang P, Liu C, Yang X, Zhou Y, Wei X, Ji Q et al (2014) Effects of low-level laser therapy on joint pain, synovitis, anabolic, and catabolic factors in a progressive osteoarthritis rabbit model. Lasers Med Sci 29(6):1875–1885CrossRefPubMed
45.
Zurück zum Zitat Colombo F, Neto Ade A, Sousa AP, Marchionni AM, Pinheiro AL, Reis SR (2013) Effect of low-level laser therapy (lambda660 nm) on angiogenesis in wound healing: a immunohistochemical study in a rodent model. Braz Dent J 24(4):308–312CrossRefPubMed Colombo F, Neto Ade A, Sousa AP, Marchionni AM, Pinheiro AL, Reis SR (2013) Effect of low-level laser therapy (lambda660 nm) on angiogenesis in wound healing: a immunohistochemical study in a rodent model. Braz Dent J 24(4):308–312CrossRefPubMed
46.
Zurück zum Zitat da Rosa AS, dos Santos AF, da Silva MM, Facco GG, Perreira DM, Alves AC et al (2012) Effects of low-level laser therapy at wavelengths of 660 and 808 nm in experimental model of osteoarthritis. Photochem Photobiol 88(1):161–166CrossRefPubMed da Rosa AS, dos Santos AF, da Silva MM, Facco GG, Perreira DM, Alves AC et al (2012) Effects of low-level laser therapy at wavelengths of 660 and 808 nm in experimental model of osteoarthritis. Photochem Photobiol 88(1):161–166CrossRefPubMed
47.
Zurück zum Zitat Roberts DB, Kruse RJ, Stoll SF (2013) The effectiveness of therapeutic class IV (10 W) laser treatment for epicondylitis. Lasers Surg Med 45(5):311–317CrossRefPubMed Roberts DB, Kruse RJ, Stoll SF (2013) The effectiveness of therapeutic class IV (10 W) laser treatment for epicondylitis. Lasers Surg Med 45(5):311–317CrossRefPubMed
48.
Zurück zum Zitat Bayat M, Ansari E, Gholami N, Bayat A (2007) Effect of low-level helium-neon laser therapy on histological and ultrastructural features of immobilized rabbit articular cartilage. J Photochem Photobiol B 87(2):81–87CrossRefPubMed Bayat M, Ansari E, Gholami N, Bayat A (2007) Effect of low-level helium-neon laser therapy on histological and ultrastructural features of immobilized rabbit articular cartilage. J Photochem Photobiol B 87(2):81–87CrossRefPubMed
49.
Zurück zum Zitat Lin YS, Huang MH, Chai CY, Yang RC (2004) Effects of helium-neon laser on levels of stress protein and arthritic histopathology in experimental osteoarthritis. Am J Phys Med Rehabil 83(10):758–765CrossRefPubMed Lin YS, Huang MH, Chai CY, Yang RC (2004) Effects of helium-neon laser on levels of stress protein and arthritic histopathology in experimental osteoarthritis. Am J Phys Med Rehabil 83(10):758–765CrossRefPubMed
50.
Zurück zum Zitat Sawitzke AD, Shi H, Finco MF, Dunlop DD, Bingham CO 3rd, Harris CL et al (2008) The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: a report from the glucosamine/chondroitin arthritis intervention trial. Arthritis Rheum 58(10):3183–3191CrossRefPubMedPubMedCentral Sawitzke AD, Shi H, Finco MF, Dunlop DD, Bingham CO 3rd, Harris CL et al (2008) The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: a report from the glucosamine/chondroitin arthritis intervention trial. Arthritis Rheum 58(10):3183–3191CrossRefPubMedPubMedCentral
51.
Zurück zum Zitat Sawitzke AD, Shi H, Finco MF, Dunlop DD, Harris CL, Singer NG et al (2010) Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2-year results from GAIT. Ann Rheum Dis 69(8):1459–1464CrossRefPubMedPubMedCentral Sawitzke AD, Shi H, Finco MF, Dunlop DD, Harris CL, Singer NG et al (2010) Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2-year results from GAIT. Ann Rheum Dis 69(8):1459–1464CrossRefPubMedPubMedCentral
52.
Zurück zum Zitat Kahan A, Uebelhart D, De Vathaire F, Delmas PD, Reginster JY (2009) Long-term effects of chondroitins 4 and 6 sulfate on knee osteoarthritis: the study on osteoarthritis progression prevention, a two-year, randomized, double-blind, placebo-controlled trial. Arthritis Rheum 60(2):524–533CrossRefPubMed Kahan A, Uebelhart D, De Vathaire F, Delmas PD, Reginster JY (2009) Long-term effects of chondroitins 4 and 6 sulfate on knee osteoarthritis: the study on osteoarthritis progression prevention, a two-year, randomized, double-blind, placebo-controlled trial. Arthritis Rheum 60(2):524–533CrossRefPubMed
53.
Zurück zum Zitat Ferreira de Meneses SR, Hunter DJ, Young Docko E, Pasqual Marques A (2015) Effect of low-level laser therapy (904 nm) and static stretching in patients with knee osteoarthritis: a protocol of randomised controlled trial. BMC Musculoskelet Disord 16:252CrossRefPubMedPubMedCentral Ferreira de Meneses SR, Hunter DJ, Young Docko E, Pasqual Marques A (2015) Effect of low-level laser therapy (904 nm) and static stretching in patients with knee osteoarthritis: a protocol of randomised controlled trial. BMC Musculoskelet Disord 16:252CrossRefPubMedPubMedCentral
54.
Zurück zum Zitat Huang MH, Lin YS, Yang RC, Lee CL (2003) A comparison of various therapeutic exercises on the functional status of patients with knee osteoarthritis. Semin Arthritis Rheum 32(6):398–406CrossRefPubMed Huang MH, Lin YS, Yang RC, Lee CL (2003) A comparison of various therapeutic exercises on the functional status of patients with knee osteoarthritis. Semin Arthritis Rheum 32(6):398–406CrossRefPubMed
55.
Zurück zum Zitat Weng MC, Lee CL, Chen CH, Hsu JJ, Lee WD, Huang MH et al (2009) Effects of different stretching techniques on the outcomes of isokinetic exercise in patients with knee osteoarthritis. Kaohsiung J Med Sci 25(6):306–315CrossRefPubMed Weng MC, Lee CL, Chen CH, Hsu JJ, Lee WD, Huang MH et al (2009) Effects of different stretching techniques on the outcomes of isokinetic exercise in patients with knee osteoarthritis. Kaohsiung J Med Sci 25(6):306–315CrossRefPubMed
Metadaten
Titel
Efficacy of pulsed Nd:YAG laser in the treatment of patients with knee osteoarthritis: a randomized controlled trial
verfasst von
Mohamed Salaheldien Mohamed Alayat
Tarek Helmy Ahmed Aly
Aly Elsayed Mohamed Elsayed
Ammar Suliman Mohamed Fadil
Publikationsdatum
11.01.2017
Verlag
Springer London
Erschienen in
Lasers in Medical Science / Ausgabe 3/2017
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI
https://doi.org/10.1007/s10103-017-2141-x

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