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Skull base versus non-skull base meningioma surgery in the elderly

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Abstract

To compare outcomes after surgery for skull base meningiomas (SBMs) with non-skull base meningiomas (NSBMs) in the elderly. Overall, 128 consecutive patients ≥ 70 years of age with intracranial SBMs operated between 1990 and 2010 were compared to 193 consecutive patients ≥ 70 years of age with NSBMs operated within the same time period. Median age at surgery was 75.0 years (mean 75.7, range 70.0–92.4). Follow-up was complete with median 4.7 years (mean 5.5, range 0–19). The female-to-male ratio was 2.8 for SBMs and 1.3 for NSBMs (p < 0.005). The groups had similar preoperative KPS (median 80, range 20–100), but SBMs presented significantly more frequently with raised ICP (RR = 2.2, p < 0.005) and less frequently with seizures (RR = 0.6, p < 0.05). WHO I was significantly more frequent in SBMs (p < 0.005). Gross-total resection (GTR) was less frequent in SBMs (63 vs 82%) (RR = 2.1, p < 0.0001). SBMs were similar to NSBMs with respect to neurological outcome at 6–12 months, reoperations for hematomas, postoperative infections, and 30-day mortality. Retreatment rates and time to retreatments were also similar. There were no differences between the two groups with respect to risk of retreatment and overall survival (OS) at 5, 10, 15, and 20 years. In elderly patients with SBMs selected to surgical treatment, the risks of surgery, risk of retreatment, and OS were similar to NBSMs. Therefore, surgery for SBMs may be considered as safe as NSBMs in the elderly population.

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Acknowledgements

The authors would like to thank Bernt Filip Hasseleid MD, Andreas Mathisen MD, Andreas Hessen Schei MD, and Kristina M Ødegaard MD for their valuable contributions in collecting data for this manuscript.

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  1. Faculty of Medicine, University of Oslo, Oslo, Norway

    Torstein R. Meling, Michele Da Broi & Eirik Helseth

  2. Department of Neurosurgery, Oslo University Hospital, N-0027, Oslo, Norway

    Torstein R. Meling & Eirik Helseth

  3. Section of Neuropathology, Rigshospitalet, Copenhagen, Denmark

    David Scheie

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Meling, T.R., Da Broi, M., Scheie, D. et al. Skull base versus non-skull base meningioma surgery in the elderly. Neurosurg Rev 42, 961–972 (2019). https://doi.org/10.1007/s10143-018-1005-6

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