Erschienen in:
01.12.2011 | Case Report
A case of acute aortic thrombosis after cisplatin-based chemotherapy
verfasst von:
Suk Jae Hahn, Jin Young Oh, Jeung Sook Kim, Do Yeun Kim
Erschienen in:
International Journal of Clinical Oncology
|
Ausgabe 6/2011
Einloggen, um Zugang zu erhalten
Abstract
Cisplatin-based therapy is associated with various toxicities, including renal failure and neuropathy. However, acute arterial thrombosis is also a possible toxic effect of cisplatin, one that has been documented in a few cases worldwide. Here we present a rare case of ascending aortic thrombosis occurring 9 days after cisplatin-based chemotherapy in a 74-year-old male who was diagnosed with malignant pleural effusion suggestive of non-small cell lung cancer. The patient did not have any predisposing factor for the occurrence of an aortic thrombus before cisplatin-based chemotherapy. Thus, we suggest that the hypercoagulable state occurred secondary to cisplatin-based chemotherapy and was additive to the malignancy itself, causing aortic thrombosis. The patient was treated successfully with low-molecular-weight heparin and warfarin.