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Comparison of systemic inflammatory and nutritional scores in colorectal cancer patients who underwent potentially curative resection

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Abstract

Background

Various systemic inflammatory and nutritional scores have been reported to predict postoperative outcomes. This study aimed to investigate the best systemic inflammatory and nutritional scores in colorectal cancer (CRC) patients who underwent potentially curative resection.

Method

We evaluated 468 consecutive CRC patients in this study. Comparisons of systemic inflammatory and nutritional scores, including the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), prognostic index (PI), prognostic nutritional index (PNI), and modified Glasgow prognostic score (mGPS), were performed using univariate/multivariate analyses for patient survival.

Results

The PNI and mGPS, but not the NLR, PLR, and PI, were significantly associated with overall and relapse-free survival. The mGPS, but not the PNI, was strongly correlated with TNM stage (P < 0.001). Cox multivariate analysis showed that both the PNI and mGPS were exclusive independent prognostic factors for both overall and relapse-free survival (P < 0.001). Furthermore, the PNI status predicted patient survival more clearly than the mGPS in combination with TNM stage.

Conclusions

This study suggests that the PNI and mGPS are useful predictive scores in CRC patients who undergo potentially curative resection, especially the PNI in combination with TNM stage. Routine evaluation of the host status using the scores may be useful in CRC treatment.

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Abbreviations

CRC:

Colorectal cancer

mGPS:

Modified Glasgow prognostic score

CRP:

C-reactive protein

NLR:

Neutrophil to lymphocyte ratio

PLR:

Platelet to lymphocyte ratio

PI:

Prognostic index

PNI:

Prognostic nutritional index

BMI:

Body mass index

CEA:

Carcinoembryonic antigen

HR:

Hazard ratio

CI:

Confidence interval

OS:

Overall survival

DFS:

Disease-free survival

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Authors and Affiliations

  1. Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan

    Ryuma Tokunaga, Yasuo Sakamoto, Shigeki Nakagawa, Daisuke Izumi, Keisuke Kosumi, Katsunobu Taki, Takaaki Higashi, Tatsunori Miyata, Yuji Miyamoto, Naoya Yoshida & Hideo Baba

Authors
  1. Ryuma Tokunaga
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  2. Yasuo Sakamoto
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  3. Shigeki Nakagawa
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  4. Daisuke Izumi
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  5. Keisuke Kosumi
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  6. Katsunobu Taki
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  7. Takaaki Higashi
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  8. Tatsunori Miyata
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  9. Yuji Miyamoto
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  10. Naoya Yoshida
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  11. Hideo Baba
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Corresponding author

Correspondence to Hideo Baba.

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The authors have no conflict of interest to declare.

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Cite this article

Tokunaga, R., Sakamoto, Y., Nakagawa, S. et al. Comparison of systemic inflammatory and nutritional scores in colorectal cancer patients who underwent potentially curative resection . Int J Clin Oncol 22, 740–748 (2017). https://doi.org/10.1007/s10147-017-1102-5

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  • DOI: https://doi.org/10.1007/s10147-017-1102-5

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