Discrepancy between serum levels of low molecular weight proteins in acute kidney injury model rats with bilateral ureteral obstruction and bilateral nephrectomy

In the sham group, the mean ± SD of creatinine, BUN, cystatin C and beta-2-MG were 0.19 ± 0.01 mg/dl, 22.6 ± 1.9 mg/dl, 1.27 ± 0.18 mg/l and 3.57 ± 0.42 mg/l, respectively. Following BNX, the values significantly rose to 4.79 ± 0.17 mg/dl, 116.9 ± 2.6 mg/dl, 2.59 ± 0.18 mg/l and 9.03 ± 0.52 mg/l compared with sham, respectively. Following BUO, they were 3.99 ± 0.25 mg/dl, 130.3 ± 12.9 mg/dl, 1.94 ± 0.35 mg/l and 4.78 ± 0.24 mg/l, respectively. Increasing amounts of creatinine and BUN in BUO were similar to those in BNX. On the other hand, cystatin C and beta-2 MG in BUO were much lower compared with BNX (P < 0.01 and <0.001, respectively). Fold increases of cystatin C and beta-2-MG in BUO were only 51% and 22% of those in BNX, respectively. There was no significant difference in CPK levels between the BUO and BNX groups.